Benzo[b]thiophene-2-carboxamide, N-[(1S)-1-[[[1-[(4-fluorophenyl)sulfonyl]hexahydro-3-hydroxy-1H-azepin- 4-yl]amino]carbonyl]-3-methylbutyl]-

Base Information

• Chemical Name: Benzo[b]thiophene-2-carboxamide, N-[(1S)-1-[[[1-[(4-fluorophenyl)sulfonyl]hexahydro-3-hydroxy-1H-azepin- 4-yl]amino]carbonyl]-3-methylbutyl]-
• CAS No.: 878649-35-5
• Molecular Formula: C27H32FN3O5S2
• Molecular Weight: 561.699

Synonyms:

Chemical Property of Benzo[b]thiophene-2-carboxamide, N-[(1S)-1-[[[1-[(4-fluorophenyl)sulfonyl]hexahydro-3-hydroxy-1H-azepin- 4-yl]amino]carbonyl]-3-methylbutyl]-

Chemical Property:

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Technology Process of Benzo[b]thiophene-2-carboxamide, N-[(1S)-1-[[[1-[(4-fluorophenyl)sulfonyl]hexahydro-3-hydroxy-1H-azepin- 4-yl]amino]carbonyl]-3-methylbutyl]-

There total 1 articles about Benzo[b]thiophene-2-carboxamide, N-[(1S)-1-[[[1-[(4-fluorophenyl)sulfonyl]hexahydro-3-hydroxy-1H-azepin- 4-yl]amino]carbonyl]-3-methylbutyl]- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

benzothiophene-2-carboxylic acid chloride (39827-11-7) + (S)-2-amino-4-methyl-pentanoic acid [3-hydroxy-1-(4-fluorobenzenesulfonyl)-azepan-4-yl]-amide hydrochloride (878649-34-4) → (S)-2-(2-benzo[b]thiophene-2-carboxylic acid)-4-methyl-pentanoic acid [3-hydroxy-1-(4-fluorobenzenesulfonyl)-azepan-4-yl]-amide (878649-35-5)

Guidance literature:

(S)-2-amino-4-methyl-pentanoic acid [3-hydroxy-1-(4-fluorobenzenesulfonyl)-azepan-4-yl]-amide hydrochloride; With carbonate-polystyrene resin; In methanol; for 2h; Polystyrene

benzothiophene-2-carboxylic acid chloride; With morpholinemethyl polystyrene resin; In 1,2-dichloro-ethane;

With trisamine polystyrene; In 1,2-dichloro-ethane; for 1.5h;

Reference yield:

(S)-2-(2-benzo[b]thiophene-2-carboxylic acid)-4-methyl-pentanoic acid [3-hydroxy-1-(4-fluorobenzenesulfonyl)-azepan-4-yl]-amide (878649-35-5) → N-{(1S)-1-[({(4R)-1-[(4-fluorophenyl)suIfonyI]-3-oxohexahydro-1H-azepin-4-yl}amino)carbonyI]-3-methyIbutyl}-1-benzothiophene-2-carboxamide (281216-61-3) + C27H30FN3O5S2 (281218-65-3)

Guidance literature:

With Dess-Martin periodane; In dichloromethane; for 0.5h;

upstream raw materials:

benzothiophene-2-carboxylic acid chloride

(S)-2-amino-4-methyl-pentanoic acid [3-hydroxy-1-(4-fluorobenzenesulfonyl)-azepan-4-yl]-amide hydrochloride

Downstream raw materials:

N-{(1S)-1-[({(4R)-1-[(4-fluorophenyl)suIfonyI]-3-oxohexahydro-1H-azepin-4-yl}amino)carbonyI]-3-methyIbutyl}-1-benzothiophene-2-carboxamide

C₂₇H₃₀FN₃O₅S₂

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