N-((1-Ethyl-2-pyrrolidinyl)methyl)-2-methyl-4-propoxy-5-pyrimidinecarboxamide

Base Information

Chemical Name:N-((1-Ethyl-2-pyrrolidinyl)methyl)-2-methyl-4-propoxy-5-pyrimidinecarboxamide
CAS No.:72412-07-8
Molecular Formula:C₁₆H₂₆N₄O₂
Molecular Weight:306.408
Hs Code.:
DSSTox Substance ID:DTXSID50993211
Nikkaji Number:J70.349D

Synonyms:BRN 0922317;72412-07-8;N-((1-Ethyl-2-pyrrolidinyl)methyl)-2-methyl-4-propoxy-5-pyrimidinecarboxamide;5-Pyrimidinecarboxamide, N-((1-ethyl-2-pyrrolidinyl)methyl)-2-methyl-4-propoxy-;N-[(1-Ethyl-2-pyrrolidinyl)methyl]-2-methyl-4-propoxy-5-pyrimidinecarboxamide;SCHEMBL1013798;DTXSID50993211;LS-134820;N-[(1-Ethylpyrrolidin-2-yl)methyl]-2-methyl-4-propoxypyrimidine-5-carboximidic acid

Suppliers and Price of N-((1-Ethyl-2-pyrrolidinyl)methyl)-2-methyl-4-propoxy-5-pyrimidinecarboxamide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of N-((1-Ethyl-2-pyrrolidinyl)methyl)-2-methyl-4-propoxy-5-pyrimidinecarboxamide

Chemical Property:

Vapor Pressure:8.69E-09mmHg at 25°C
Boiling Point:464°Cat760mmHg
Flash Point:234.4°C
Density:1.083g/cm³
XLogP3:2
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:7
Exact Mass:306.20557608
Heavy Atom Count:22
Complexity:353

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CCCOC1=NC(=NC=C1C(=O)NCC2CCCN2CC)C

Technology Process of N-((1-Ethyl-2-pyrrolidinyl)methyl)-2-methyl-4-propoxy-5-pyrimidinecarboxamide

There total 4 articles about N-((1-Ethyl-2-pyrrolidinyl)methyl)-2-methyl-4-propoxy-5-pyrimidinecarboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 2134-36-3
ethyl 4-chloro-2-methylpyrimidine-5-carboxylate

: 84332-34-3,72412-07-8
2-methyl-4-propoxy-pyrimidine-5-carboxylic acid (1-ethyl-pyrrolidin-2-ylmethyl)-amide

Guidance literature:: Multi-step reaction with 3 steps

1: 50 percent / sodium / Ambient temperature

2: NaOH / methanol; H₂O / 1 h / 65 °C

3: 1.) triethylamine, ethylchloroformate / 1.)THF, 0 deg C, 30 min, 2.) room temp. overnight

With sodium hydroxide; sodium; chloroformic acid ethyl ester; triethylamine; In methanol; water;

Reference yield:

: 72419-44-4
2-methyl-4-propoxy-pyrimidine-5-carboxylic acid propyl ester

: 84332-34-3,72412-07-8
2-methyl-4-propoxy-pyrimidine-5-carboxylic acid (1-ethyl-pyrrolidin-2-ylmethyl)-amide

Guidance literature:: Multi-step reaction with 2 steps

1: NaOH / methanol; H₂O / 1 h / 65 °C

2: 1.) triethylamine, ethylchloroformate / 1.)THF, 0 deg C, 30 min, 2.) room temp. overnight

With sodium hydroxide; chloroformic acid ethyl ester; triethylamine; In methanol; water;

Reference yield:

: 26116-12-1
1-ethyl-2-pyrrolidinemethanamine

: 72411-82-6
2-methyl-4-propoxy-pyrimidine-5-carboxylic acid

: 84332-34-3,72412-07-8
2-methyl-4-propoxy-pyrimidine-5-carboxylic acid (1-ethyl-pyrrolidin-2-ylmethyl)-amide

Guidance literature:: With chloroformic acid ethyl ester; triethylamine; Yield given. Multistep reaction; 1.)THF, 0 deg C, 30 min, 2.) room temp. overnight;