DL-3-Aminoisobutyric acid

Base Information

• Chemical Name: DL-3-Aminoisobutyric acid
• CAS No.: 10569-72-9
• Molecular Formula: C4H9NO2
• Molecular Weight: 103.121
• Hs Code.: 2922499990
• Mol file: 10569-72-9.mol

Synonyms:(1)-3-Amino-2-methylpropionic acid;(±)-b-Aminoisobutyric acid;DL-Beta-Aminoisobutyric Acid;H-Aib-OH;

Chemical Property of DL-3-Aminoisobutyric acid

Chemical Property:

• Appearance/Colour: white crystal or crystalline powder
• Melting Point: 179-182 °C(lit.)
• Refractive Index: 1.4650 (estimate)
• Boiling Point: 223.6 °C at 760 mmHg
• Flash Point: 89 °C
• PSA: 63.32000
• Density: 1.105 g/cm³
• LogP: 0.36610
• Storage Temp.: -20°C
• Solubility.: Methanol (Slightly), Water (Slightly)

Purity/Quality:

98% ^*data from raw suppliers

DL-3-Aminoisobutyric acid 98% ^*data from reagent suppliers

Safty Information:

• Safety Statements: 22-24/25

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Uses: DL-3-Aminoisobutyric Acid is a useful compound for suppressing atherosclerosis in apolipoprotein E-knockout mouse.

Technology Process of DL-3-Aminoisobutyric acid

There total 52 articles about DL-3-Aminoisobutyric acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

2-benzyl-4-methylisoxazolidin-5-one (95503-63-2) → DL-3-aminoisobutyric acid (10569-72-9)

Guidance literature:

With palladium on activated charcoal; hydrogen; In 1,4-dioxane; water; at 85 ℃; for 16h;

DOI:10.1016/S0040-4020(01)98811-8

Reference yield: 87.0%

4-methyl-N-(S)-1-phenylethylisoxazolidin-5-one (95503-68-7,95503-69-8) → DL-3-aminoisobutyric acid (10569-72-9)

Guidance literature:

With palladium on activated charcoal; hydrogen; In 1,4-dioxane; water; at 85 ℃; for 16h;

DOI:10.1016/S0040-4020(01)98811-8

Reference yield: 69.0%

trans-1-benzoyl-2-tert-butyl-3,5-dimethylperhydropyrimidin-4-one (131932-58-6) → DL-3-aminoisobutyric acid (10569-72-9)

Guidance literature:

With hydrogenchloride; at 180 ℃; for 8h;

DOI:10.1021/jo00007a053

upstream raw materials:

2-cyanopropanoic acid

(benzoylamino-methyl)-methyl-malonic acid diethyl ester

ethyl 2-cyanopropionate

methyl methacrylate

Downstream raw materials:

N-tert-butoxycarbonyl-3-amino-2(RS)-methylpropionic acid

3-[3-(4-Isopropoxy-phenyl)-thioureido]-2-methyl-propionic acid

3-[3-(4-Methoxy-phenyl)-thioureido]-2-methyl-propionic acid

2-Methyl-3-[3-(4-propoxy-phenyl)-thioureido]-propionic acid

Refernces

• 1、 Okomoto,S. et al.. "-". . p. 2670 - 2673. Retrieved 1979.
• 2、 Saladino, Raffaele,Botta, Giorgia,Delfino, Michela,Di Mauro, Ernesto. "Meteorites as catalysts for prebiotic chemistry". . p. 16916 - 16922. Retrieved 2013.
• 3、 Beom, Ji Yoon,Byun, Woong Sub,Chung, Beomkoo,Hong, Suckchang,Jeon, Chang-Wook,Kang, Saeyeon,Kwak, Youn-Sig,Lee, Jeeyeon,Lee, Sang Kook,Oh, Dong-Chan,Oh, Ki-Bong,Shin, Jongheon,Shin, Yern-Hyerk,Yoon, Yeo Joon. "Absolute Configuration and Antibiotic Activity of Piceamycin". . . Retrieved 2020.
• 4、 Gani, David,Hitchcock, Peter B.,Young, Douglas W.. "Stereochemistry of the Metabolism of the DNA Base Thymine and the Drug 5-Fluorouracil". . p. 898 - 900. Retrieved 1983.
• 5、 Park, Seon-Hui,Moon, Kyuho,Bang, Hea-Son,Kim, Seong-Hwan,Kim, Dong-Gyu,Oh, Ki-Bong,Shin, Jongheon,Oh, Dong-Chan. "Tripartilactam, a cyclobutane-bearing tricyclic lactam from a Streptomyces sp. in a dung beetle's brood ball". . p. 1258 - 1261. Retrieved 2012.
• 6、 Dietrich et al.. "". . p. 1894. Retrieved 1979.
• 7、 Zilkha,A. et al.. "-". . p. 1686 - 1689. Retrieved 1968.
• 8、 Zhu, Chendan,Mandrelli, Francesca,Zhou, Hui,Maji, Rajat,List, Benjamin. "Catalytic Asymmetric Synthesis of Unprotected β2-Amino Acids". supporting information. p. 3312 - 3317. Retrieved 2021/04/07.