3-(4-TRIFLUOROMETHYLBENZOYL)THIOPHENE

Base Information

• Chemical Name: 3-(4-TRIFLUOROMETHYLBENZOYL)THIOPHENE
• CAS No.: 879218-18-5
• Molecular Formula: C₁₂H₇F₃OS
• Molecular Weight: 256.248
• Mol file: 879218-18-5.mol

Synonyms:3-(4-TRIFLUOROMETHYLBENZOYL)THIOPHENE;

Chemical Property of 3-(4-TRIFLUOROMETHYLBENZOYL)THIOPHENE

Chemical Property:

• Vapor Pressure: 0.000442mmHg at 25°C
• Boiling Point: 315.3oC at 760 mmHg
• Flash Point: 144.5oC
• PSA: 45.31000
• Density: 1.344g/cm3
• LogP: 3.99790

Purity/Quality:

95% ^*data from raw suppliers

3-(4-Trifluoromethylbenzoyl)thiophene 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3-(4-TRIFLUOROMETHYLBENZOYL)THIOPHENE

There total 2 articles about 3-(4-TRIFLUOROMETHYLBENZOYL)THIOPHENE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

4-trifluoromethyl-phenyl acetyl chloride (329-15-7) + 3-thienylzinc bromide (188755-01-3) → thiophen-3-yl(4-(trifluoromethyl)phenyl)methanone (879218-18-5)

Guidance literature:

3-thienylzinc bromide; With CCl₂CuLi₂N; In tetrahydrofuran; at -20 - 0 ℃; Inert atmosphere;

4-trifluoromethyl-phenyl acetyl chloride; In tetrahydrofuran; at -20 - 20 ℃; for 2h; Inert atmosphere;

DOI:10.1021/jo102417x

Reference yield: 44.0%

Thien-3-ylboronic acid (6165-69-1) + 4-trifluoromethylbenzoic acid (455-24-3) → thiophen-3-yl(4-(trifluoromethyl)phenyl)methanone (879218-18-5)

Guidance literature:

With P(p-CH₃OC₆H₄)3; carbonic acid dimethyl ester; palladium diacetate; In tetrahydrofuran; water; at 40 ℃;

DOI:10.1016/j.tetlet.2005.12.122

upstream raw materials:

Thien-3-ylboronic acid

4-trifluoromethylbenzoic acid

4-trifluoromethyl-phenyl acetyl chloride

3-thienylzinc bromide

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