Pyridine, 2-[4-[4-fluoro-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]-1-[[ 2-(trimethylsilyl)ethoxy]methyl]-1H-pyrazol-3-yl]-6-methyl-

Base Information

Chemical Name:Pyridine, 2-[4-[4-fluoro-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]-1-[[ 2-(trimethylsilyl)ethoxy]methyl]-1H-pyrazol-3-yl]-6-methyl-
CAS No.:879487-60-2
Molecular Formula:C27H37BFN3O3Si
Molecular Weight:509.504
Hs Code.:

Pyridine,
2-[4-[4-fluoro-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]-1-[[
2-(trimethylsilyl)ethoxy]methyl]-1H-pyrazol-3-yl]-6-methyl-

Synonyms:

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Chemical Property of Pyridine, 2-[4-[4-fluoro-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]-1-[[ 2-(trimethylsilyl)ethoxy]methyl]-1H-pyrazol-3-yl]-6-methyl-

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Technology Process of Pyridine, 2-[4-[4-fluoro-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]-1-[[ 2-(trimethylsilyl)ethoxy]methyl]-1H-pyrazol-3-yl]-6-methyl-

There total 5 articles about Pyridine, 2-[4-[4-fluoro-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]-1-[[ 2-(trimethylsilyl)ethoxy]methyl]-1H-pyrazol-3-yl]-6-methyl- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 69.0%

: 879487-59-9
2-(4-(3-Bromo-4-fluorophenyl)-1-([2-(trimethylsilyl)ethoxy]methyl)-1H-pyrazol-3-yl)-6-methylpyridine

: 73183-34-3
bis(pinacol)diborane

: 879487-60-2
2-(4-[4-Fluoro-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]-1-{[2-(trimethylsilyl)ethoxy]methyl}-1H-pyrazol-3-yl)-6-methylpyridine

Guidance literature:: With potassium acetate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; In N,N-dimethyl-formamide; at 100 ℃; for 8h;

Reference yield:

: 1122-72-1
6-methyl-2-pyridinecarboxaldehyde

: 879487-60-2
2-(4-[4-Fluoro-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]-1-{[2-(trimethylsilyl)ethoxy]methyl}-1H-pyrazol-3-yl)-6-methylpyridine

Guidance literature:: Multi-step reaction with 5 steps

1.1: isopropyl alcohol / 1 h / 20 °C

2.1: caesium carbonate / tetrahydrofuran; isopropyl alcohol / 2 h / 20 °C

2.2: 1 h / 20 °C

3.1: N,N-dimethyl-formamide / 2 h / 20 - 90 °C

3.2: 3 h / 20 °C

4.1: sodium hydride / tetrahydrofuran / 0.33 h / 0 - 20 °C

4.2: 3 h / 20 °C

5.1: potassium acetate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / N,N-dimethyl-formamide / 8 h / 100 °C

With potassium acetate; sodium hydride; caesium carbonate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; In tetrahydrofuran; N,N-dimethyl-formamide; isopropyl alcohol;

Reference yield:

: 1282894-23-8
2-(3-bromo-4-fluorophenyl)-1-(6-methylpyridin-2-yl)ethanone

: 879487-60-2
2-(4-[4-Fluoro-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]-1-{[2-(trimethylsilyl)ethoxy]methyl}-1H-pyrazol-3-yl)-6-methylpyridine

Guidance literature:: Multi-step reaction with 3 steps

1.1: N,N-dimethyl-formamide / 2 h / 20 - 90 °C

1.2: 3 h / 20 °C

2.1: sodium hydride / tetrahydrofuran / 0.33 h / 0 - 20 °C

2.2: 3 h / 20 °C

3.1: potassium acetate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / N,N-dimethyl-formamide / 8 h / 100 °C

With potassium acetate; sodium hydride; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; In tetrahydrofuran; N,N-dimethyl-formamide;