1,2-Pyrrolidinedicarboxylic acid, 2-[(1S)-1-[3-[[(1,1-dimethylethyl)diphenylsilyl]oxy]propyl]-4-pentenyl]-5-[( phenylmethoxy)methyl]-, 1-(1,1-dimethylethyl) 2-methyl ester, (2S,5S)-

Base Information

Chemical Name:1,2-Pyrrolidinedicarboxylic acid, 2-[(1S)-1-[3-[[(1,1-dimethylethyl)diphenylsilyl]oxy]propyl]-4-pentenyl]-5-[( phenylmethoxy)methyl]-, 1-(1,1-dimethylethyl) 2-methyl ester, (2S,5S)-
CAS No.:879572-73-3
Molecular Formula:C43H59NO6Si
Molecular Weight:714.03
Hs Code.:

1,2-Pyrrolidinedicarboxylic acid,
2-[(1S)-1-[3-[[(1,1-dimethylethyl)diphenylsilyl]oxy]propyl]-4-pentenyl]-5-[(
phenylmethoxy)methyl]-, 1-(1,1-dimethylethyl) 2-methyl ester, (2S,5S)-

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Suppliers and Price of 1,2-Pyrrolidinedicarboxylic acid, 2-[(1S)-1-[3-[[(1,1-dimethylethyl)diphenylsilyl]oxy]propyl]-4-pentenyl]-5-[( phenylmethoxy)methyl]-, 1-(1,1-dimethylethyl) 2-methyl ester, (2S,5S)-

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 1,2-Pyrrolidinedicarboxylic acid, 2-[(1S)-1-[3-[[(1,1-dimethylethyl)diphenylsilyl]oxy]propyl]-4-pentenyl]-5-[( phenylmethoxy)methyl]-, 1-(1,1-dimethylethyl) 2-methyl ester, (2S,5S)-

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Technology Process of 1,2-Pyrrolidinedicarboxylic acid, 2-[(1S)-1-[3-[[(1,1-dimethylethyl)diphenylsilyl]oxy]propyl]-4-pentenyl]-5-[( phenylmethoxy)methyl]-, 1-(1,1-dimethylethyl) 2-methyl ester, (2S,5S)-

There total 1 articles about 1,2-Pyrrolidinedicarboxylic acid, 2-[(1S)-1-[3-[[(1,1-dimethylethyl)diphenylsilyl]oxy]propyl]-4-pentenyl]-5-[( phenylmethoxy)methyl]-, 1-(1,1-dimethylethyl) 2-methyl ester, (2S,5S)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 73.0%

: 879572-70-0
(2S,5S)-1-tert-butyl 2-methyl 5-(benzyloxymethyl)-2-[(R)-6-(tert-butyldiphenylsilyloxy)hex-1-en-3-yl]pyrrolidine-1,2-dicarboxylate

: 593-60-2,25951-54-6
Vinyl bromide

: 879572-73-3
(2S,5S)-1-tert-butyl 2-methyl 5-(benzyloxymethyl)-2-[(S)-1-(tert-butyldiphenylsilyloxy)oct-7-en-4-yl]pyrrolidine-1,2-dicarboxylate

Guidance literature:: (2S,5S)-1-tert-butyl 2-methyl 5-(benzyloxymethyl)-2-[(R)-6-(tert-butyldiphenylsilyloxy)hex-1-en-3-yl]pyrrolidine-1,2-dicarboxylate; With 9-borabicyclo[3.3.1]nonane dimer; In tetrahydrofuran; at 50 ℃; for 2h;

Vinyl bromide; With triphenyl-arsane; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; In tetrahydrofuran; N,N-dimethyl-formamide; at 40 ℃; for 2h;
DOI:10.1021/ol053010j

Reference yield: 91.0%

: 879572-73-3
(2S,5S)-1-tert-butyl 2-methyl 5-(benzyloxymethyl)-2-[(S)-1-(tert-butyldiphenylsilyloxy)oct-7-en-4-yl]pyrrolidine-1,2-dicarboxylate

: 879572-74-4
(2S,5S)-1-tert-butyl 5-(benzyloxymethyl)-2-[(S)-1-(tert-butyldiphenylsilyloxy)oct-7-en-4-yl]-2-(hydroxymethyl)pyrrolidine-1-carboxylate

Guidance literature:: With lithium aluminium tetrahydride; In tetrahydrofuran; at 0 ℃; for 0.5h;
DOI:10.1021/ol053010j

Reference yield:

: 879572-73-3
(2S,5S)-1-tert-butyl 2-methyl 5-(benzyloxymethyl)-2-[(S)-1-(tert-butyldiphenylsilyloxy)oct-7-en-4-yl]pyrrolidine-1,2-dicarboxylate

: 5-benzyloxymethyl-2-{1-[3-(tert-butyl-diphenyl-silanyloxy)-propyl]-pent-4-enyl}-2-formyl-pyrrolidine-1-carboxylic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 91 percent / LiAlH₄ / tetrahydrofuran / 0.5 h / 0 °C

2: oxalyl chloride; DMSO; triethylamine / CH₂Cl₂ / -78 - 0 °C

With lithium aluminium tetrahydride; oxalyl dichloride; dimethyl sulfoxide; triethylamine; In tetrahydrofuran; dichloromethane; 2: Swern oxidation;
DOI:10.1021/ol053010j