1,2-Pyrrolidinedicarboxylic acid, 2-[(1R)-4-[[(1,1-dimethylethyl)diphenylsilyl]oxy]-1-ethenylbutyl]-5-[(phenyl methoxy)methyl]-, 1-(1,1-dimethylethyl) 2-methyl ester, (2S,5S)-

Base Information

Chemical Name:1,2-Pyrrolidinedicarboxylic acid, 2-[(1R)-4-[[(1,1-dimethylethyl)diphenylsilyl]oxy]-1-ethenylbutyl]-5-[(phenyl methoxy)methyl]-, 1-(1,1-dimethylethyl) 2-methyl ester, (2S,5S)-
CAS No.:879572-70-0
Molecular Formula:C41H55NO6Si
Molecular Weight:685.976
Hs Code.:

1,2-Pyrrolidinedicarboxylic acid,
2-[(1R)-4-[[(1,1-dimethylethyl)diphenylsilyl]oxy]-1-ethenylbutyl]-5-[(phenyl
methoxy)methyl]-, 1-(1,1-dimethylethyl) 2-methyl ester, (2S,5S)-

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Suppliers and Price of 1,2-Pyrrolidinedicarboxylic acid, 2-[(1R)-4-[[(1,1-dimethylethyl)diphenylsilyl]oxy]-1-ethenylbutyl]-5-[(phenyl methoxy)methyl]-, 1-(1,1-dimethylethyl) 2-methyl ester, (2S,5S)-

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Chemical Property of 1,2-Pyrrolidinedicarboxylic acid, 2-[(1R)-4-[[(1,1-dimethylethyl)diphenylsilyl]oxy]-1-ethenylbutyl]-5-[(phenyl methoxy)methyl]-, 1-(1,1-dimethylethyl) 2-methyl ester, (2S,5S)-

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Technology Process of 1,2-Pyrrolidinedicarboxylic acid, 2-[(1R)-4-[[(1,1-dimethylethyl)diphenylsilyl]oxy]-1-ethenylbutyl]-5-[(phenyl methoxy)methyl]-, 1-(1,1-dimethylethyl) 2-methyl ester, (2S,5S)-

There total 1 articles about 1,2-Pyrrolidinedicarboxylic acid, 2-[(1R)-4-[[(1,1-dimethylethyl)diphenylsilyl]oxy]-1-ethenylbutyl]-5-[(phenyl methoxy)methyl]-, 1-(1,1-dimethylethyl) 2-methyl ester, (2S,5S)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

: 879572-68-6
(2S,5S)-5-(benzyloxymethyl)-1-(tert-butoxycarbonyl)-2-[(R)-6-(tert-butyldiphenylsilyloxy)hex-1-en-3-yl]pyrrolidine-2-carboxylic acid

: 74-88-4
methyl iodide

: 879572-70-0
(2S,5S)-1-tert-butyl 2-methyl 5-(benzyloxymethyl)-2-[(R)-6-(tert-butyldiphenylsilyloxy)hex-1-en-3-yl]pyrrolidine-1,2-dicarboxylate

Guidance literature:: With potassium carbonate; In acetone; for 12h; Heating;
DOI:10.1021/ol053010j

Reference yield: 89.0%

: 879572-70-0
(2S,5S)-1-tert-butyl 2-methyl 5-(benzyloxymethyl)-2-[(R)-6-(tert-butyldiphenylsilyloxy)hex-1-en-3-yl]pyrrolidine-1,2-dicarboxylate

: (2S,5S)-1-tert-butyl 2-methyl 5-(benzyloxymethyl)-2-((S)-5-(tert-butyldiphenylsilyloxy)-1-oxopentan-2-yl)pyrrolidine-1,2-dicarboxylate

Guidance literature:: (2S,5S)-1-tert-butyl 2-methyl 5-(benzyloxymethyl)-2-[(R)-6-(tert-butyldiphenylsilyloxy)hex-1-en-3-yl]pyrrolidine-1,2-dicarboxylate; With ozone; In methanol; dichloromethane; at -78 ℃; for 0.333333h; Inert atmosphere;

With triphenylphosphine; In methanol; dichloromethane; at -78 - 20 ℃; for 3h; Inert atmosphere;
DOI:10.1002/chem.201404316

Reference yield: 73.0%

: 879572-70-0
(2S,5S)-1-tert-butyl 2-methyl 5-(benzyloxymethyl)-2-[(R)-6-(tert-butyldiphenylsilyloxy)hex-1-en-3-yl]pyrrolidine-1,2-dicarboxylate

: 593-60-2,25951-54-6
Vinyl bromide

: 879572-73-3
(2S,5S)-1-tert-butyl 2-methyl 5-(benzyloxymethyl)-2-[(S)-1-(tert-butyldiphenylsilyloxy)oct-7-en-4-yl]pyrrolidine-1,2-dicarboxylate

Guidance literature:: (2S,5S)-1-tert-butyl 2-methyl 5-(benzyloxymethyl)-2-[(R)-6-(tert-butyldiphenylsilyloxy)hex-1-en-3-yl]pyrrolidine-1,2-dicarboxylate; With 9-borabicyclo[3.3.1]nonane dimer; In tetrahydrofuran; at 50 ℃; for 2h;

Vinyl bromide; With triphenyl-arsane; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; In tetrahydrofuran; N,N-dimethyl-formamide; at 40 ℃; for 2h;
DOI:10.1021/ol053010j