4-ethyl-3-hydrazinyl-4H-1,2,4-benzothiadiazine 1,1-dioxide

Base Information

• Chemical Name: 4-ethyl-3-hydrazinyl-4H-1,2,4-benzothiadiazine 1,1-dioxide
• CAS No.: 107089-80-5
• Molecular Formula: C₉H₁₂N₄O₂S
• Molecular Weight: 240.286
• Mol file: 107089-80-5.mol

Synonyms:2H-1,2,4-Benzothiadiazin-3(4H)-one,4-ethyl-, hydrazone, 1,1-dioxide (9CI); NSC 373859

Chemical Property of 4-ethyl-3-hydrazinyl-4H-1,2,4-benzothiadiazine 1,1-dioxide

Chemical Property:

• Vapor Pressure: 7.49E-08mmHg at 25°C
• Boiling Point: 437.4°Cat760mmHg
• Flash Point: 218.3°C
• Density: 1.53g/cm³

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-ethyl-3-hydrazinyl-4H-1,2,4-benzothiadiazine 1,1-dioxide

There total 4 articles about 4-ethyl-3-hydrazinyl-4H-1,2,4-benzothiadiazine 1,1-dioxide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

NSC 373854 (107089-77-0) → 3-hydrazino-4-ethyl-4H-1,2,4-benzothiadiazine 1,1-dioxide (107089-80-5)

Guidance literature:

With hydrazine hydrate; In chloroform; for 0.5h; Ambient temperature;

Reference yield:

4-ethyl-2H-1,2,4-benzothiadiazine-3 (4H)-one 1,1-dioxide (102308-74-7) → 3-hydrazino-4-ethyl-4H-1,2,4-benzothiadiazine 1,1-dioxide (107089-80-5)

Guidance literature:

Multi-step reaction with 2 steps

1: PCl₅ / 0.5 h / 190 °C

2: hydrazine hydrate / CHCl₃ / 10 °C

With phosphorus pentachloride; hydrazine hydrate; In chloroform;

DOI:10.1016/j.bmc.2005.08.063

Reference yield:

C9H11ClN2O3S → 3-hydrazino-4-ethyl-4H-1,2,4-benzothiadiazine 1,1-dioxide (107089-80-5)

Guidance literature:

Multi-step reaction with 3 steps

1: aluminium chloride / 0.5 h / 120 °C

2: PCl₅ / 0.5 h / 190 °C

3: hydrazine hydrate / CHCl₃ / 10 °C

With aluminium trichloride; phosphorus pentachloride; hydrazine hydrate; In chloroform;

DOI:10.1016/j.bmc.2005.08.063

upstream raw materials:

NSC 373854

4-ethyl-2H-1,2,4-benzothiadiazine-3 (4H)-one 1,1-dioxide

N-ethyl-N-phenylamine

Downstream raw materials:

2-(4-Ethyl-1,1-dioxo-1,4-dihydro-1λ⁶-benzo[1,2,4]thiadiazin-3-yl)-5-methyl-2,4-dihydro-pyrazol-3-one

3-(3,5-Dimethyl-pyrazol-1-yl)-4-ethyl-4H-benzo[1,2,4]thiadiazine 1,1-dioxide