Benzenesulfonamide, N-[(1R,5S,8S)-5,8-dihydroxy-1-propyldodecyl]-4-methyl-

Base Information

Chemical Name:Benzenesulfonamide, N-[(1R,5S,8S)-5,8-dihydroxy-1-propyldodecyl]-4-methyl-
CAS No.:880135-66-0
Molecular Formula:C22H39NO4S
Molecular Weight:413.622
Hs Code.:

Synonyms:

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Chemical Property of Benzenesulfonamide, N-[(1R,5S,8S)-5,8-dihydroxy-1-propyldodecyl]-4-methyl-

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Technology Process of Benzenesulfonamide, N-[(1R,5S,8S)-5,8-dihydroxy-1-propyldodecyl]-4-methyl-

There total 12 articles about Benzenesulfonamide, N-[(1R,5S,8S)-5,8-dihydroxy-1-propyldodecyl]-4-methyl- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 2100-17-6
4-pentenal

: 880135-66-0
N-((1R,5S,8S)-5,8-Dihydroxy-1-propyl-dodecyl)-4-methyl-benzenesulfonamide

Guidance literature:: Multi-step reaction with 8 steps

1.1: Zn(OTf)2; triethylamine; chiral 3-TBDMSO-2-(dimethylamino)-1-(4-nitrophenyl)propanol / toluene / 0.25 h / 20 °C

1.2: 83 percent / toluene / 12 h

2.1: 98 percent / 2,6-lutidine / CH₂Cl₂ / 1 h

3.1: 78 percent / m-CPBA / CH₂Cl₂ / 3.5 h / 20 °C

4.1: 92 percent / H₂ / Pd/C / ethyl acetate / 2 h / 760 Torr

5.1: 49 percent / AcOH; H₂O / chiral salen cobalt(II) complex / tetrahydrofuran / 0 - 20 °C

6.1: t-BuLi / diethyl ether / 1 h / -78 - -45 °C

6.2: diethyl ether / 5 h / -78 - -25 °C

6.3: 56 percent / hexamethylphosphoramide / diethyl ether / -78 - 0 °C

7.1: H₂; Raney nickel / ethanol; H₂O / 8 h / 20 °C / 760 Torr

8.1: 0.020 g / tetrabutylammonium fluoride / tetrahydrofuran / 36 h / 20 °C

With 2,6-dimethylpyridine; chiral 3-TBDMSO-2-(dimethylamino)-1-(4-nitrophenyl)propanol; tetrabutyl ammonium fluoride; water; hydrogen; tert.-butyl lithium; zinc trifluoromethanesulfonate; nickel; acetic acid; triethylamine; 3-chloro-benzenecarboperoxoic acid; palladium on activated charcoal; chiral salen cobalt(II); In tetrahydrofuran; diethyl ether; ethanol; dichloromethane; water; ethyl acetate; toluene;
DOI:10.1021/jo052314g

Reference yield:

: 692730-51-1
(R)-Non-1-en-6-yn-5-ol

: 880135-66-0
N-((1R,5S,8S)-5,8-Dihydroxy-1-propyl-dodecyl)-4-methyl-benzenesulfonamide

Guidance literature:: Multi-step reaction with 7 steps

1.1: 98 percent / 2,6-lutidine / CH₂Cl₂ / 1 h

2.1: 78 percent / m-CPBA / CH₂Cl₂ / 3.5 h / 20 °C

3.1: 92 percent / H₂ / Pd/C / ethyl acetate / 2 h / 760 Torr

4.1: 49 percent / AcOH; H₂O / chiral salen cobalt(II) complex / tetrahydrofuran / 0 - 20 °C

5.1: t-BuLi / diethyl ether / 1 h / -78 - -45 °C

5.2: diethyl ether / 5 h / -78 - -25 °C

5.3: 56 percent / hexamethylphosphoramide / diethyl ether / -78 - 0 °C

6.1: H₂; Raney nickel / ethanol; H₂O / 8 h / 20 °C / 760 Torr

7.1: 0.020 g / tetrabutylammonium fluoride / tetrahydrofuran / 36 h / 20 °C

With 2,6-dimethylpyridine; tetrabutyl ammonium fluoride; water; hydrogen; tert.-butyl lithium; nickel; acetic acid; 3-chloro-benzenecarboperoxoic acid; palladium on activated charcoal; chiral salen cobalt(II); In tetrahydrofuran; diethyl ether; ethanol; dichloromethane; water; ethyl acetate;
DOI:10.1021/jo052314g

Reference yield:

: 692730-63-5
tert-butyl-dimethyl-[1-(2-oxiranyl-ethyl)-pentyloxy]-silane

: 880135-66-0
N-((1R,5S,8S)-5,8-Dihydroxy-1-propyl-dodecyl)-4-methyl-benzenesulfonamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: 49 percent / AcOH; H₂O / chiral salen cobalt(II) complex / tetrahydrofuran / 0 - 20 °C

2.1: t-BuLi / diethyl ether / 1 h / -78 - -45 °C

2.2: diethyl ether / 5 h / -78 - -25 °C

2.3: 56 percent / hexamethylphosphoramide / diethyl ether / -78 - 0 °C

3.1: H₂; Raney nickel / ethanol; H₂O / 8 h / 20 °C / 760 Torr

4.1: 0.020 g / tetrabutylammonium fluoride / tetrahydrofuran / 36 h / 20 °C

With tetrabutyl ammonium fluoride; water; hydrogen; tert.-butyl lithium; nickel; acetic acid; chiral salen cobalt(II); In tetrahydrofuran; diethyl ether; ethanol; water;
DOI:10.1021/jo052314g