AcetaMide, 2,2,2-trifluoro-N-(3-Methylphenyl)-

Base Information

• Chemical Name: AcetaMide, 2,2,2-trifluoro-N-(3-Methylphenyl)-
• CAS No.: 2727-69-7
• Molecular Formula: C9H8 F3 N O
• Molecular Weight: 203.164
• Mol file: 2727-69-7.mol

Synonyms:m-Acetotoluidide,2,2,2-trifluoro- (7CI,8CI); m-Methyltrifluoroacetanilide

Chemical Property of AcetaMide, 2,2,2-trifluoro-N-(3-Methylphenyl)-

Chemical Property:

• Vapor Pressure: 0.021mmHg at 25°C
• Boiling Point: 251°Cat760mmHg
• Flash Point: 105.6°C
• PSA: 32.59000
• Density: 1.309g/cm³
• LogP: 3.14530

Purity/Quality:

99% ^*data from raw suppliers

2,2,2-TRIFLUORO-N-(3-METHYLPHENYL)ACETAMIDE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of AcetaMide, 2,2,2-trifluoro-N-(3-Methylphenyl)-

There total 6 articles about AcetaMide, 2,2,2-trifluoro-N-(3-Methylphenyl)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

1-amino-3-methylbenzene (108-44-1) + trifluoroacetic acid (76-05-1) → N-(3-methylphenyl)-2,2,2-trifluoroacetamide (2727-69-7)

Guidance literature:

With bis(trichloromethyl) carbonate; triethylamine; In dichloromethane; at 20 ℃; for 0.25h;

DOI:10.2174/157017811797249317

Reference yield: 90.0%

1-amino-3-methylbenzene (108-44-1) + trifluoroacetic anhydride (407-25-0) → N-(3-methylphenyl)-2,2,2-trifluoroacetamide (2727-69-7)

Guidance literature:

In diethyl ether; for 2h; 0 deg C to r.t.;

DOI:10.1055/s-1995-3990

Reference yield: 21.0%

acetic anhydride (108-24-7) + 3,3,3-Trifluoro-1-phenyl-2-[(E)-m-tolylimino]-propan-1-ol → N-(3-methylphenyl)-2,2,2-trifluoroacetamide (2727-69-7) + 3,3,3-trifluoro-2-(3-methylphenylimino)-1-phenylpropyl acetate

Guidance literature:

With pyridine; Ambient temperature;

DOI:10.1246/bcsj.67.300

upstream raw materials:

1-amino-3-methylbenzene

trifluoroacetic anhydride

acetic anhydride

trifluoroacetic acid

Downstream raw materials:

4-methyl-N-(m-tolyl)benzamide

3-methyl-N-(2,2,2-trifluoroethyl)aniline

Refernces

• 1、 Zhao, Chenxi,Tang, Chu,Li, Changhao,Ning, Wentao,Hu, Zhiye,Xin, Lilan,Zhou, Hai-Bing,Huang, Jian. "Novel hybrid conjugates with dual estrogen receptor α degradation and histone deacetylase inhibitory activities for breast cancer therapy". . . Retrieved 2021/05/10.
• 2、 Han, Ki-Jong,Kim, Misoo. "A simple and efficient method for trifluoroacetylation of arylamines using trifluoroacetic acid and triphosgene". experimental part. p. 559 - 561. Retrieved 2012/06/04.