Carbamic acid, [(1R)-1-[[[(1,1-dimethylethyl)diphenylsilyl]oxy]methyl]-3-[2-(hydroxymethyl )-1-cyclohexen-1-yl]propyl]-, 1,1-dimethylethyl ester

Base Information

• Chemical Name: Carbamic acid, [(1R)-1-[[[(1,1-dimethylethyl)diphenylsilyl]oxy]methyl]-3-[2-(hydroxymethyl )-1-cyclohexen-1-yl]propyl]-, 1,1-dimethylethyl ester
• CAS No.: 880152-31-8
• Molecular Formula: C32H47NO4Si
• Molecular Weight: 537.815
• Mol file: 880152-31-8.mol

Synonyms:

Chemical Property of Carbamic acid, [(1R)-1-[[[(1,1-dimethylethyl)diphenylsilyl]oxy]methyl]-3-[2-(hydroxymethyl )-1-cyclohexen-1-yl]propyl]-, 1,1-dimethylethyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Carbamic acid, [(1R)-1-[[[(1,1-dimethylethyl)diphenylsilyl]oxy]methyl]-3-[2-(hydroxymethyl )-1-cyclohexen-1-yl]propyl]-, 1,1-dimethylethyl ester

There total 6 articles about Carbamic acid, [(1R)-1-[[[(1,1-dimethylethyl)diphenylsilyl]oxy]methyl]-3-[2-(hydroxymethyl )-1-cyclohexen-1-yl]propyl]-, 1,1-dimethylethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-[3-tert-butoxycarbonylamino-4-(tert-butyl-diphenyl-silanyloxy)-butyl]-cyclohex-1-enecarboxylic acid ethyl ester → [1-(tert-butyl-diphenyl-silanyloxymethyl)-3-(2-hydroxymethyl-cyclohex-1-enyl)-propyl]-carbamic acid tert-butyl ester (880152-31-8)

Guidance literature:

With diisobutylaluminium hydride; In hexane; dichloromethane; at -78 - 0 ℃;

DOI:10.1021/ol053059p

Reference yield:

4-[2-(2-ethoxycarbonyl-cyclohex-1-enyl)-ethyl]-2,2-dimethyl-oxazolidine-3-carboxylic acid tert-butyl ester (880152-29-4) → [1-(tert-butyl-diphenyl-silanyloxymethyl)-3-(2-hydroxymethyl-cyclohex-1-enyl)-propyl]-carbamic acid tert-butyl ester (880152-31-8)

Guidance literature:

Multi-step reaction with 3 steps

1: pyridinium p-toluenesulfonate / methanol / 1 h / Heating

2: imidazole / CH₂Cl₂ / 20 °C

3: 12.0 g / DIBAL-H / CH₂Cl₂ / -78 - 0 °C

With 1H-imidazole; pyridinium p-toluenesulfonate; diisobutylaluminium hydride; In methanol; dichloromethane;

Reference yield:

2-(3-tert-butoxycarbonylamino-4-hydroxy-butyl)-cyclohex-1-enecarboxylic acid ethyl ester (880152-30-7) → [1-(tert-butyl-diphenyl-silanyloxymethyl)-3-(2-hydroxymethyl-cyclohex-1-enyl)-propyl]-carbamic acid tert-butyl ester (880152-31-8)

Guidance literature:

Multi-step reaction with 2 steps

1: imidazole / CH₂Cl₂ / 20 °C

2: 12.0 g / DIBAL-H / CH₂Cl₂ / -78 - 0 °C

With 1H-imidazole; diisobutylaluminium hydride; In dichloromethane;

upstream raw materials:

2-(3-tert-butoxycarbonylamino-4-hydroxy-butyl)-cyclohex-1-enecarboxylic acid ethyl ester

4-[2-(2-ethoxycarbonyl-cyclohex-1-enyl)-ethyl]-2,2-dimethyl-oxazolidine-3-carboxylic acid tert-butyl ester

4-[2-(9-bora-bicyclo[3.3.1]non-9-yl)-ethyl]-2,2-dimethyl-oxazolidine-3-carboxylic acid tert-butyl ester

ethyl 2-trifluoromethanesulfonyloxycyclohex-1-enecarboxylate

Downstream raw materials:

acetic acid 2-[3-amino-4-(tert-butyl-diphenyl-silanyloxy)-butyl]-cyclohex-1-enylmethyl ester

3-(tert-butyl-diphenyl-silanyloxymethyl)-5-hexyl-2,3,8,9,10,11-hexahydro-1H,7aH-pyrrolo[2,1-j]quinolin-7-one

C₃₆H₄₅NO₃Si

C₃₆H₄₅NO₃Si