ETHYL 2-(TRIFLUOROMETHYL SULFONYLOXY)-1-CYCLOHEXENE-1-CARBOXYLATE

Base Information

• Chemical Name: ETHYL 2-(TRIFLUOROMETHYL SULFONYLOXY)-1-CYCLOHEXENE-1-CARBOXYLATE
• CAS No.: 122135-83-5
• Molecular Formula: C10H13 F3 O5 S
• Molecular Weight: 302.271
• Hs Code.: 2916209090
• Mol file: 122135-83-5.mol

Synonyms:2-Ethoxycarbonyl-1-cyclohexenyltriflate; 2-[(Trifluoromethylsulfonyl)oxy]cyclohex-1-ene-1-carboxylic acidethyl ester; Ethyl 2-(triflyloxy)-1-cyclohexenecarboxylate; NSC 698179

Chemical Property of ETHYL 2-(TRIFLUOROMETHYL SULFONYLOXY)-1-CYCLOHEXENE-1-CARBOXYLATE

Chemical Property:

• Vapor Pressure: 0.00021mmHg at 25°C
• Boiling Point: 326.9°Cat760mmHg
• Flash Point: 151.5°C
• PSA: 78.05000
• Density: 1.41g/cm³
• LogP: 3.32460
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C

Purity/Quality:

97% ^*data from raw suppliers

Ethyl2-(Trifluoromethylsulfonyloxy)-1-cyclohenxene-1-carboxylate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: Ethyl 2-(Trifluoromethyl sulfonyloxy)-1-cyclohenxene-1-carboxylate is a useful building block in organic synthesis.

Technology Process of ETHYL 2-(TRIFLUOROMETHYL SULFONYLOXY)-1-CYCLOHEXENE-1-CARBOXYLATE

There total 7 articles about ETHYL 2-(TRIFLUOROMETHYL SULFONYLOXY)-1-CYCLOHEXENE-1-CARBOXYLATE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

trifluoromethylsulfonic anhydride (358-23-6) + ethyl 2-oxocyclohexane carboxylate (1655-07-8) → ethyl 2-trifluoromethanesulfonyloxycyclohex-1-enecarboxylate (122135-83-5)

Guidance literature:

With N-ethyl-N,N-diisopropylamine; In dichloromethane; at -78 - 20 ℃;

DOI:10.1021/ja0212009

Reference yield: 92.0%

N,N-phenylbistrifluoromethane-sulfonimide (37595-74-7) + ethyl 2-oxocyclohexane carboxylate (1655-07-8) → ethyl 2-trifluoromethanesulfonyloxycyclohex-1-enecarboxylate (122135-83-5)

Guidance literature:

With sodium hydride; In N,N-dimethyl-formamide; at 0 - 20 ℃;

DOI:10.1021/ol0362461

Reference yield: 90.0%

N-(5-chloropyridin-2-yl)-1,1,1-trifluoro-N-[(trifluoromethyl)sulphonyl]methanesulphonamide (145100-51-2) + ethyl 2-oxocyclohexane carboxylate (1655-07-8) → ethyl 2-trifluoromethanesulfonyloxycyclohex-1-enecarboxylate (122135-83-5)

Guidance literature:

With sodium hydride; In tetrahydrofuran;

DOI:10.1016/j.bmcl.2008.04.071

upstream raw materials:

N,N-phenylbistrifluoromethane-sulfonimide

ethyl 2-oxocyclohexane carboxylate

phenyl trifluoromethanesulfonamide

trifluoromethylsulfonic anhydride

Downstream raw materials:

2-ethyl-1-methyl-1H-indole

2-Carbethoxyclohexen-1-yl 1-methylindol-2-yl ketone

2-(1-Methyl-allyl)-cyclohex-1-enecarboxylic acid ethyl ester

2-Vinyl-cyclohex-1-enecarboxylic acid ethyl ester