2H-Pyran-2-one, 4-[[(1R)-3-[2-[(acetyloxy)methyl]-1-cyclohexen-1-yl]-1-[[[(1,1-dimethyleth yl)diphenylsilyl]oxy]methyl]propyl]amino]-6-butyl-

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Chemical Name:2H-Pyran-2-one, 4-[[(1R)-3-[2-[(acetyloxy)methyl]-1-cyclohexen-1-yl]-1-[[[(1,1-dimethyleth yl)diphenylsilyl]oxy]methyl]propyl]amino]-6-butyl-
CAS No.:880152-33-0
Molecular Formula:C38H51NO5Si
Molecular Weight:629.912
Hs Code.:

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Chemical Property of 2H-Pyran-2-one, 4-[[(1R)-3-[2-[(acetyloxy)methyl]-1-cyclohexen-1-yl]-1-[[[(1,1-dimethyleth yl)diphenylsilyl]oxy]methyl]propyl]amino]-6-butyl-

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Technology Process of 2H-Pyran-2-one, 4-[[(1R)-3-[2-[(acetyloxy)methyl]-1-cyclohexen-1-yl]-1-[[[(1,1-dimethyleth yl)diphenylsilyl]oxy]methyl]propyl]amino]-6-butyl-

There total 9 articles about 2H-Pyran-2-one, 4-[[(1R)-3-[2-[(acetyloxy)methyl]-1-cyclohexen-1-yl]-1-[[[(1,1-dimethyleth yl)diphenylsilyl]oxy]methyl]propyl]amino]-6-butyl- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 61.0%

: 880152-32-9
4-bromo-6-butyl-2-pyrone

: 880152-28-3
acetic acid 2-[3-amino-4-(tert-butyl-diphenyl-silanyloxy)-butyl]-cyclohex-1-enylmethyl ester

: 880152-33-0
acetic acid 2-[4-(tert-butyl-diphenyl-silanyloxy)-3-(6-butyl-2-oxo-2H-pyran-4-ylamino)-butyl]-cyclohex-1-enylmethyl ester

Guidance literature:: With pyridine; In ethanol; for 48h; Heating;
DOI:10.1021/ol053059p

Reference yield:

: 880152-30-7
2-(3-tert-butoxycarbonylamino-4-hydroxy-butyl)-cyclohex-1-enecarboxylic acid ethyl ester

: 880152-33-0
acetic acid 2-[4-(tert-butyl-diphenyl-silanyloxy)-3-(6-butyl-2-oxo-2H-pyran-4-ylamino)-butyl]-cyclohex-1-enylmethyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: imidazole / CH₂Cl₂ / 20 °C

2: 12.0 g / DIBAL-H / CH₂Cl₂ / -78 - 0 °C

3: pyridine / 20 °C

4: 100 percent / TFA / CH₂Cl₂ / 1 h / 0 °C

5: 61 percent / pyridine / ethanol / 48 h / Heating

With pyridine; 1H-imidazole; diisobutylaluminium hydride; trifluoroacetic acid; In ethanol; dichloromethane;

Reference yield:

: 880152-29-4
4-[2-(2-ethoxycarbonyl-cyclohex-1-enyl)-ethyl]-2,2-dimethyl-oxazolidine-3-carboxylic acid tert-butyl ester

: 880152-33-0
acetic acid 2-[4-(tert-butyl-diphenyl-silanyloxy)-3-(6-butyl-2-oxo-2H-pyran-4-ylamino)-butyl]-cyclohex-1-enylmethyl ester

Guidance literature:: Multi-step reaction with 6 steps

1: pyridinium p-toluenesulfonate / methanol / 1 h / Heating

2: imidazole / CH₂Cl₂ / 20 °C

3: 12.0 g / DIBAL-H / CH₂Cl₂ / -78 - 0 °C

4: pyridine / 20 °C

5: 100 percent / TFA / CH₂Cl₂ / 1 h / 0 °C

6: 61 percent / pyridine / ethanol / 48 h / Heating

With pyridine; 1H-imidazole; pyridinium p-toluenesulfonate; diisobutylaluminium hydride; trifluoroacetic acid; In methanol; ethanol; dichloromethane;