5-Chloro-2h-chromen-2-one

Base Information

• Chemical Name: 5-Chloro-2h-chromen-2-one
• CAS No.: 38169-98-1
• Molecular Formula: C9H5ClO2
• Molecular Weight: 180.59
• NSC Number: 26427
• DSSTox Substance ID: DTXSID80282544
• Nikkaji Number: J651.686F
• Wikidata: Q82016842
• ChEMBL ID: CHEMBL1964466
• Mol file: 38169-98-1.mol

Synonyms:5-chloro-2h-chromen-2-one;38169-98-1;5-Chlorocoumarin;5-chlorochromen-2-one;2H-1-Benzopyran-2-one, 5-chloro-;5-chloranylchromen-2-one;NSC26427;5-chloro-1-benzopyran-2-one;CHEMBL1964466;SCHEMBL11035090;DTXSID80282544;MFCD13181735;NSC-26427;NCI60_002118;SY036155;FT-0761625;A827125

Chemical Property of 5-Chloro-2h-chromen-2-one

Chemical Property:

• Vapor Pressure: 0.00015mmHg at 25°C
• Refractive Index: 1.608
• Boiling Point: 332 °C at 760 mmHg
• Flash Point: 179.8 °C
• PSA: 30.21000
• Density: 1.399 g/cm³
• LogP: 2.44640
• XLogP3: 2.5
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 0
• Exact Mass: 179.9978071
• Heavy Atom Count: 12
• Complexity: 225

Purity/Quality:

99% ^*data from raw suppliers

5-Chloro-2H-chromen-2-one 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC2=C(C=CC(=O)O2)C(=C1)Cl

Technology Process of 5-Chloro-2h-chromen-2-one

There total 15 articles about 5-Chloro-2h-chromen-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

3-monochlorophenol (108-43-0) + malic acid (617-48-1,78644-42-5) → 5-Chlor-2H-1-benzopyran-2-on (38169-98-1)

Guidance literature:

With pyridine; sulfuric acid; at 117 ℃; for 0.0416667h; Microwave irradiation;

DOI:10.1055/s-2008-1067238

Reference yield: 83.0%

m-chlorophenyl propiolate → 7-Chlor-2H-1-benzopyran-2-on (19063-54-8) + 5-Chlor-2H-1-benzopyran-2-on (38169-98-1)

Guidance literature:

With Echavarren's catalyst; In dichloromethane; at 18 ℃; for 1h;

DOI:10.1021/acs.joc.0c02011

Reference yield: 81.0%

2-chloro-6-hydroxybenzaldehyde (18362-30-6) + acetic anhydride (108-24-7) → 5-Chlor-2H-1-benzopyran-2-on (38169-98-1)

Guidance literature:

With sodium acetate; at 180 - 190 ℃; for 18h;

DOI:10.1016/S0040-4020(01)98965-3

upstream raw materials:

trimetylsilylketene

2-chloro-6-hydroxybenzaldehyde

methyl (2Z)-3-(2,6-dichlorophenyl)prop-2-enoate

methyl (2E)-3-(2,6-dichlorophenyl)prop-2-enoate

Downstream raw materials:

2-chloro-6-methoxy-cis-cinnamic acid

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 38169-98-1 5-Chlorocoumarin

Send

Send

Metric Ton KG G Pound L ML

Send

Send