19063-54-8

Basic information

• Product Name: 7-Chloro-2H-chromen-2-one
• Synonyms: 7-Chloro-2H-chromen-2-one
• CAS NO: 19063-54-8
• Molecular Weight: 180.59
• Mol File: 19063-54-8.mol
• Article Data: 13

Chemical Properties

• CAS DataBase Reference: 7-Chloro-2H-chromen-2-one(CAS DataBase Reference)
• NIST Chemistry Reference: 7-Chloro-2H-chromen-2-one(19063-54-8)
• EPA Substance Registry System: 7-Chloro-2H-chromen-2-one(19063-54-8)

Safety Data

• Hazardous Substances Data: 19063-54-8(Hazardous Substances Data)

Upstream product

• 108-43-0 3-monochlorophenol 
• 617-48-1 malic acid 
• 292638-85-8 acrylic acid methyl ester 
• 2019-34-3 3-(4-chlorophenyl)propanoic acid 
• 1615-02-7 p-chlorocinnamic acid 
• 471-25-0 Propiolic acid 
• 53581-86-5 4-chloro-2-methoxybenzaldehyde 
• 105786-77-4 3-Ethoxyacrylsaeure-3-chlorphenylester 
• 2420-26-0 4-chlorosalicylaldehyde 
• 108-24-7 acetic anhydride 

Relevant articles and documents

Visible-Light-Induced Direct Csp2-H Radical Trifluoroethylation of Coumarins with 1,1,1-Trifluoro-2-iodoethane (CF3CH2I)

Herein, we developed the first visible-light-induced direct Csp2-H radical 2,2,2-trifluoroethylation of coumarins with commercially available and cheap reagent CF3CH2I at room temperature. This transformation proceeded smoothly under mild conditions and showed excellent functional group compatibility. The synthetic value of the protocol was also demonstrated by the successful functionalization of several pharmaceuticals.

Gold(I)-Catalyzed Intramolecular Hydroarylation of Phenol-Derived Propiolates and Certain Related Ethers as a Route to Selectively Functionalized Coumarins and 2 H-Chromenes

Methods are reported for the efficient assembly of a series of phenol-derived propiolates, including the parent system 56, and their Au(I)-catalyzed cyclization (intramolecular hydroarylation) to give the corresponding coumarins (e.g., 1). Simple syntheses of natural products such as ayapin (144) and scoparone (145) have been realized by such means, and the first of these subject to single-crystal X-ray analysis. A related process is described for the conversion of propargyl ethers such as 156 into the isomeric 2H-chromene precocene I (159), a naturally occurring inhibitor of juvenile hormone biosynthesis.

Visible-light-induced regioselective alkylation of coumarins via decarboxylative coupling with N-hydroxyphthalimide esters

An efficient photocatalytic decarboxylative 3-position alkylation of coumarins by using alkyl N-hydroxyphthalimide esters as alkylation reagents has been developed. A variety of NHP esters derived from aliphatic carboxylic acids (primary, secondary, and tertiary) has been proved to be tolerated for this decarboxylation process, affording a broad scope of 3-alkylated coumarin derivatives in moderate to excellent yields. This protocol was highlighted by its mild conditions, readily available starting materials, operational simplicity, and wide functional group tolerance.