[[(2R,3S,4R,5R)-5-(2-amino-6-oxo-3H-purin-9-yl)-3,4-dihydroxyoxolan-2-yl]methoxy-hydroxyphosphoryl] [(2R,3S,4R,5R)-5-(2-amino-6-oxo-3H-purin-9-yl)-3,4-dihydroxyoxolan-2-yl]methyl hydrogen phosphate

Base Information

• Chemical Name: [[(2R,3S,4R,5R)-5-(2-amino-6-oxo-3H-purin-9-yl)-3,4-dihydroxyoxolan-2-yl]methoxy-hydroxyphosphoryl] [(2R,3S,4R,5R)-5-(2-amino-6-oxo-3H-purin-9-yl)-3,4-dihydroxyoxolan-2-yl]methyl hydrogen phosphate
• CAS No.: 34692-44-9
• Molecular Formula: C20H26 N10 O15 P2
• Molecular Weight: 708.432
• Mol file: 34692-44-9.mol

Synonyms:Guanosine5'-(trihydrogen pyrophosphate), 5'®5'-ester with guanosine (8CI); Diguanosine 5',5'''-diphosphate; Gp2G

Chemical Property of [[(2R,3S,4R,5R)-5-(2-amino-6-oxo-3H-purin-9-yl)-3,4-dihydroxyoxolan-2-yl]methoxy-hydroxyphosphoryl] [(2R,3S,4R,5R)-5-(2-amino-6-oxo-3H-purin-9-yl)-3,4-dihydroxyoxolan-2-yl]methyl hydrogen phosphate

Chemical Property:

• Vapor Pressure: 0mmHg at 25°C
• Boiling Point: 1258.5°Cat760mmHg
• Flash Point: 714.9°C
• PSA: 400.47000
• Density: 2.6g/cm³
• LogP: -2.93140

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of [[(2R,3S,4R,5R)-5-(2-amino-6-oxo-3H-purin-9-yl)-3,4-dihydroxyoxolan-2-yl]methoxy-hydroxyphosphoryl] [(2R,3S,4R,5R)-5-(2-amino-6-oxo-3H-purin-9-yl)-3,4-dihydroxyoxolan-2-yl]methyl hydrogen phosphate

There total 3 articles about [[(2R,3S,4R,5R)-5-(2-amino-6-oxo-3H-purin-9-yl)-3,4-dihydroxyoxolan-2-yl]methoxy-hydroxyphosphoryl] [(2R,3S,4R,5R)-5-(2-amino-6-oxo-3H-purin-9-yl)-3,4-dihydroxyoxolan-2-yl]methyl hydrogen phosphate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 71.0%

Guanosine 5'-monophosphate (85-32-5) → α,γ-diguanosine 5'-triphosphate (6674-45-9) + guanosine-5'-diphosphate (146-91-8) + α,β-diguanosine 5'-diphosphate (34692-44-9)

Guidance literature:

With pyridine; 1-methyl-pyrrolidin-2-one; N,N,N,N,N,N-hexamethylphosphoric triamide; tributyl-amine; S,S'-bis(4-chlorophenyl) phosphorodithioate; silver nitrate; at 0 - 20 ℃; for 7h;

DOI:10.1246/cl.1994.499

Reference yield:

Guanosine 5'-monophosphate imidazolide (69281-33-0) → Guanosine 5'-monophosphate (85-32-5) + α,β-diguanosine 5'-diphosphate (34692-44-9)

Guidance literature:

With water; zinc(II) chloride; at 40 ℃; pH=8.0; Further Variations:; Temperatures; Kinetics; Activation energy;

DOI:10.1246/bcsj.74.927

Reference yield:

guanosine 5'-phosphate 2-methylimidazolide → Guanosine 5'-monophosphate (85-32-5) + α,β-diguanosine 5'-diphosphate (34692-44-9) + pG2'p5'G + 5'-phosphoguanylyl-(3'->5')-guanosine (33008-99-0)

Guidance literature:

With sodium chloride; magnesium chloride; polycytidylate; at 23 ℃; pH=7.90; Further Variations:; Reagents; Kinetics; Product distribution;

DOI:10.1021/jo991216q

upstream raw materials:

Guanosine 5'-monophosphate

Guanosine 5'-monophosphate imidazolide