Technology Process of 1-Piperazinecarboxylic acid,
6-[3-[[bis[[(1,1-dimethylethoxy)carbonyl]amino]methylene]amino]propyl]-
4-[(3,4-difluorophenyl)methyl]-2-(2-naphthalenylmethyl)-3-oxo-,
1,1-dimethylethyl ester, (2R,6R)-
There total 6 articles about 1-Piperazinecarboxylic acid,
6-[3-[[bis[[(1,1-dimethylethoxy)carbonyl]amino]methylene]amino]propyl]-
4-[(3,4-difluorophenyl)methyl]-2-(2-naphthalenylmethyl)-3-oxo-,
1,1-dimethylethyl ester, (2R,6R)- which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
di-isopropyl azodicarboxylate; triphenylphosphine;
In
tetrahydrofuran;
at 20 ℃;
for 2h;
DOI:10.1080/00397910500383550
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: sodium hydrogen carbonate; water / ethyl acetate / 0.33 h / 0 °C
1.2: 93 percent / Cs2CO3 / dimethylformamide / 2 h / 65 °C
2.1: lithium bis(trimethylsilyl)amide / tetrahydrofuran / 0.33 h / -78 °C
2.2: 69 percent / tetrahydrofuran / 2 h / -78 °C
3.1: 9-borabicyclo[3.3.1]nonane / tetrahydrofuran / 3 h / 0 - 20 °C
3.2: 78 percent / NaOH; H2O2 / tetrahydrofuran; H2O / 20 °C
4.1: 90 percent / triphenylphosphine; diisopropyl azodicarboxylate / tetrahydrofuran / 2 h / 20 °C
With
di-isopropyl azodicarboxylate; water; sodium hydrogencarbonate; 9-bora-bicyclo[3.3.1]nonane; triphenylphosphine; lithium hexamethyldisilazane;
In
tetrahydrofuran; ethyl acetate;
4.1: Nitsunobu reaction;
DOI:10.1080/00397910500383550
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: lithium bis(trimethylsilyl)amide / tetrahydrofuran / 0.33 h / -78 °C
1.2: 69 percent / tetrahydrofuran / 2 h / -78 °C
2.1: 9-borabicyclo[3.3.1]nonane / tetrahydrofuran / 3 h / 0 - 20 °C
2.2: 78 percent / NaOH; H2O2 / tetrahydrofuran; H2O / 20 °C
3.1: 90 percent / triphenylphosphine; diisopropyl azodicarboxylate / tetrahydrofuran / 2 h / 20 °C
With
di-isopropyl azodicarboxylate; 9-bora-bicyclo[3.3.1]nonane; triphenylphosphine; lithium hexamethyldisilazane;
In
tetrahydrofuran;
3.1: Nitsunobu reaction;
DOI:10.1080/00397910500383550