2-Propenoic acid, 3-[(2R,4S,6S)-6-methyl-6-[(3Z)-4-methyl-5-oxo-3-penten-1-ynyl]-2-(2,4, 6-trimethylphenyl)-1,3-dioxan-4-yl]-, methyl ester, (2Z)-

Base Information

Chemical Name:2-Propenoic acid, 3-[(2R,4S,6S)-6-methyl-6-[(3Z)-4-methyl-5-oxo-3-penten-1-ynyl]-2-(2,4, 6-trimethylphenyl)-1,3-dioxan-4-yl]-, methyl ester, (2Z)-
CAS No.:880349-22-4
Molecular Formula:C24H28O5
Molecular Weight:396.483
Hs Code.:

Synonyms:

Suppliers and Price of 2-Propenoic acid, 3-[(2R,4S,6S)-6-methyl-6-[(3Z)-4-methyl-5-oxo-3-penten-1-ynyl]-2-(2,4, 6-trimethylphenyl)-1,3-dioxan-4-yl]-, methyl ester, (2Z)-

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 2-Propenoic acid, 3-[(2R,4S,6S)-6-methyl-6-[(3Z)-4-methyl-5-oxo-3-penten-1-ynyl]-2-(2,4, 6-trimethylphenyl)-1,3-dioxan-4-yl]-, methyl ester, (2Z)-

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Purity/Quality:

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Technology Process of 2-Propenoic acid, 3-[(2R,4S,6S)-6-methyl-6-[(3Z)-4-methyl-5-oxo-3-penten-1-ynyl]-2-(2,4, 6-trimethylphenyl)-1,3-dioxan-4-yl]-, methyl ester, (2Z)-

There total 7 articles about 2-Propenoic acid, 3-[(2R,4S,6S)-6-methyl-6-[(3Z)-4-methyl-5-oxo-3-penten-1-ynyl]-2-(2,4, 6-trimethylphenyl)-1,3-dioxan-4-yl]-, methyl ester, (2Z)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 880349-19-9
(Z)-methyl 3-((4S,6S)-6-((Z)-5-hydroxy-4-methylpent-3-en-1-ynyl)-2-mesityl-6-methyl-1,3-dioxan-4-yl)acrylate

: 880349-22-4
(Z)-3-[(2R,4S,6S)-6-Methyl-6-((Z)-4-methyl-5-oxo-pent-3-en-1-ynyl)-2-(2,4,6-trimethyl-phenyl)-[1,3]dioxan-4-yl]-acrylic acid methyl ester

Guidance literature:: With Dess-Martin periodane; In dichloromethane; at 20 ℃; for 2h;
DOI:10.1021/ol0530225

Reference yield:

: 880349-12-2
(S)-1-((S)-2,2-dimethyl-1,3-dioxolan-4-yl)-2-methylbut-3-yn-2-ol

: 880349-22-4
(Z)-3-[(2R,4S,6S)-6-Methyl-6-((Z)-4-methyl-5-oxo-pent-3-en-1-ynyl)-2-(2,4,6-trimethyl-phenyl)-[1,3]dioxan-4-yl]-acrylic acid methyl ester

Guidance literature:: Multi-step reaction with 5 steps

1.1: 85 percent / camphorsulfonic acid / CH₂Cl₂ / 48 h / 0 °C

2.1: 85 percent / Dess-Martin periodinane / CH₂Cl₂ / 2 h / 20 °C

3.1: potassium hexamethyldisilamide / tetrahydrofuran / 0.17 h / -78 °C

3.2: 71 percent / tetrahydrofuran / -78 - 20 °C

4.1: 75 percent / CuI; Et₃N / Pd(PPh₃)4 / acetonitrile / 16 h / 20 °C

5.1: Dess-Martin periodinane / CH₂Cl₂ / 2 h / 20 °C

With copper(l) iodide; camphor-10-sulfonic acid; potassium hexamethylsilazane; Dess-Martin periodane; triethylamine; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; dichloromethane; acetonitrile; 3.2: Still-Gennari olefination / 4.1: Sonogashira coupling;
DOI:10.1021/ol0530225

Reference yield:

: 880349-17-7
(4S,6S)-6-ethynyl-2-mesityl-6-methyl-1,3-dioxane-4-carbaldehyde

: 880349-22-4
(Z)-3-[(2R,4S,6S)-6-Methyl-6-((Z)-4-methyl-5-oxo-pent-3-en-1-ynyl)-2-(2,4,6-trimethyl-phenyl)-[1,3]dioxan-4-yl]-acrylic acid methyl ester

Guidance literature:: Multi-step reaction with 3 steps

1.1: potassium hexamethyldisilamide / tetrahydrofuran / 0.17 h / -78 °C

1.2: 71 percent / tetrahydrofuran / -78 - 20 °C

2.1: 75 percent / CuI; Et₃N / Pd(PPh₃)4 / acetonitrile / 16 h / 20 °C

3.1: Dess-Martin periodinane / CH₂Cl₂ / 2 h / 20 °C

With copper(l) iodide; potassium hexamethylsilazane; Dess-Martin periodane; triethylamine; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; dichloromethane; acetonitrile; 1.2: Still-Gennari olefination / 2.1: Sonogashira coupling;
DOI:10.1021/ol0530225