(Z)-5-((4S,6S)-2-mesityl-6-((Z)-3-methoxy-3-oxoprop-1-enyl)-4-methyl-1,3-dioxan-4-yl)-2-methylpent-2-en-4-ynoic acid

Base Information

Chemical Name:(Z)-5-((4S,6S)-2-mesityl-6-((Z)-3-methoxy-3-oxoprop-1-enyl)-4-methyl-1,3-dioxan-4-yl)-2-methylpent-2-en-4-ynoic acid
CAS No.:880349-20-2
Molecular Formula:C₂₄H₂₈O₆
Molecular Weight:412.483
Hs Code.:

Synonyms:(Z)-5-((4S,6S)-2-mesityl-6-((Z)-3-methoxy-3-oxoprop-1-enyl)-4-methyl-1,3-dioxan-4-yl)-2-methylpent-2-en-4-ynoic acid

Suppliers and Price of (Z)-5-((4S,6S)-2-mesityl-6-((Z)-3-methoxy-3-oxoprop-1-enyl)-4-methyl-1,3-dioxan-4-yl)-2-methylpent-2-en-4-ynoic acid

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of (Z)-5-((4S,6S)-2-mesityl-6-((Z)-3-methoxy-3-oxoprop-1-enyl)-4-methyl-1,3-dioxan-4-yl)-2-methylpent-2-en-4-ynoic acid

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (Z)-5-((4S,6S)-2-mesityl-6-((Z)-3-methoxy-3-oxoprop-1-enyl)-4-methyl-1,3-dioxan-4-yl)-2-methylpent-2-en-4-ynoic acid

There total 8 articles about (Z)-5-((4S,6S)-2-mesityl-6-((Z)-3-methoxy-3-oxoprop-1-enyl)-4-methyl-1,3-dioxan-4-yl)-2-methylpent-2-en-4-ynoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 880349-22-4
(Z)-3-[(2R,4S,6S)-6-Methyl-6-((Z)-4-methyl-5-oxo-pent-3-en-1-ynyl)-2-(2,4,6-trimethyl-phenyl)-[1,3]dioxan-4-yl]-acrylic acid methyl ester

: 880349-20-2
(Z)-5-((4S,6S)-2-mesityl-6-((Z)-3-methoxy-3-oxoprop-1-enyl)-4-methyl-1,3-dioxan-4-yl)-2-methylpent-2-en-4-ynoic acid

Guidance literature:: With sodium chlorite; dihydrogen peroxide; In water; acetonitrile; at 0 ℃; for 1.5h;
DOI:10.1021/ol0530225

Reference yield:

: 880349-12-2
(S)-1-((S)-2,2-dimethyl-1,3-dioxolan-4-yl)-2-methylbut-3-yn-2-ol

: 880349-20-2
(Z)-5-((4S,6S)-2-mesityl-6-((Z)-3-methoxy-3-oxoprop-1-enyl)-4-methyl-1,3-dioxan-4-yl)-2-methylpent-2-en-4-ynoic acid

Guidance literature:: Multi-step reaction with 6 steps

1.1: 85 percent / camphorsulfonic acid / CH₂Cl₂ / 48 h / 0 °C

2.1: 85 percent / Dess-Martin periodinane / CH₂Cl₂ / 2 h / 20 °C

3.1: potassium hexamethyldisilamide / tetrahydrofuran / 0.17 h / -78 °C

3.2: 71 percent / tetrahydrofuran / -78 - 20 °C

4.1: 75 percent / CuI; Et₃N / Pd(PPh₃)4 / acetonitrile / 16 h / 20 °C

5.1: Dess-Martin periodinane / CH₂Cl₂ / 2 h / 20 °C

6.1: 180 mg / NaHPO₄*H₂O; H₂O₂; NaClO₂ / H₂O; acetonitrile / 1.5 h / 0 °C

With sodium chlorite; copper(l) iodide; camphor-10-sulfonic acid; dihydrogen peroxide; potassium hexamethylsilazane; Dess-Martin periodane; triethylamine; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; dichloromethane; water; acetonitrile; 3.2: Still-Gennari olefination / 4.1: Sonogashira coupling;
DOI:10.1021/ol0530225

Reference yield:

: 880349-17-7
(4S,6S)-6-ethynyl-2-mesityl-6-methyl-1,3-dioxane-4-carbaldehyde

: 880349-20-2
(Z)-5-((4S,6S)-2-mesityl-6-((Z)-3-methoxy-3-oxoprop-1-enyl)-4-methyl-1,3-dioxan-4-yl)-2-methylpent-2-en-4-ynoic acid

Guidance literature:: Multi-step reaction with 4 steps

1.1: potassium hexamethyldisilamide / tetrahydrofuran / 0.17 h / -78 °C

1.2: 71 percent / tetrahydrofuran / -78 - 20 °C

2.1: 75 percent / CuI; Et₃N / Pd(PPh₃)4 / acetonitrile / 16 h / 20 °C

3.1: Dess-Martin periodinane / CH₂Cl₂ / 2 h / 20 °C

4.1: 180 mg / NaHPO₄*H₂O; H₂O₂; NaClO₂ / H₂O; acetonitrile / 1.5 h / 0 °C

With sodium chlorite; copper(l) iodide; dihydrogen peroxide; potassium hexamethylsilazane; Dess-Martin periodane; triethylamine; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; dichloromethane; water; acetonitrile; 1.2: Still-Gennari olefination / 2.1: Sonogashira coupling;
DOI:10.1021/ol0530225