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Abiraterone

Base Information Edit
  • Chemical Name:Abiraterone
  • CAS No.:154229-19-3
  • Molecular Formula:C24H31NO
  • Molecular Weight:349.516
  • Hs Code.:2933399090
  • European Community (EC) Number:810-941-6
  • NSC Number:749226
  • UNII:G819A456D0
  • DSSTox Substance ID:DTXSID80879993
  • Nikkaji Number:J617.457D
  • Wikipedia:Abiraterone
  • Wikidata:Q321431
  • NCI Thesaurus Code:C77333
  • RXCUI:1100072
  • Pharos Ligand ID:RFXWMSR4FQ6A
  • Metabolomics Workbench ID:65145
  • ChEMBL ID:CHEMBL254328
  • Mol file:154229-19-3.mol
Abiraterone

Synonyms:17-(3-pyridyl)androsta-5,16-dien-3beta-ol;abiraterone;CB 7598;CB-7598;CB7598

Suppliers and Price of Abiraterone
Supply Marketing:Edit
Business phase:
The product has achieved commercial mass production*data from LookChem market partment
Manufacturers and distributors:
  • Manufacture/Brand
  • Chemicals and raw materials
  • Packaging
  • price
  • TRC
  • 7-KetoabirateroneAcetate
  • 100mg
  • $ 1455.00
  • TRC
  • Abiraterone
  • 5mg
  • $ 130.00
  • TRC
  • Abiraterone
  • 50mg
  • $ 500.00
  • Medical Isotopes, Inc.
  • 7-Ketoabirateroneacetate
  • 25 mg
  • $ 650.00
  • Medical Isotopes, Inc.
  • 7-Ketoabirateroneacetate
  • 250 mg
  • $ 2200.00
  • Matrix Scientific
  • (3Beta)-17-(3-pyridinyl)-androsta-5,16-dien-3-ol 95+%
  • 1g
  • $ 1647.00
  • Matrix Scientific
  • (3Beta)-17-(3-pyridinyl)-androsta-5,16-dien-3-ol 95+%
  • 250mg
  • $ 742.00
  • DC Chemicals
  • Abiraterone(CB-7598) 99%
  • 1 g
  • $ 800.00
  • Crysdot
  • Abiraterone 98+%
  • 250mg
  • $ 95.00
  • Crysdot
  • Abiraterone 98+%
  • 10mg
  • $ 49.00
Total 203 raw suppliers
Chemical Property of Abiraterone Edit
Chemical Property:
  • Appearance/Colour:white solid 
  • Vapor Pressure:7.99E-11mmHg at 25°C 
  • Melting Point:227-228 °C(Solv: toluene (108-88-3)) 
  • Refractive Index:1.605 
  • Boiling Point:500.17 °C at 760 mmHg 
  • PKA:14.71±0.70(Predicted) 
  • Flash Point:256.294 °C 
  • PSA:33.12000 
  • Density:1.14 g/cm3 
  • LogP:5.39860 
  • Storage Temp.:2-8°C 
  • Solubility.:Chloroform (Slightly), Methanol (Slightly) 
  • XLogP3:4.6
  • Hydrogen Bond Donor Count:1
  • Hydrogen Bond Acceptor Count:2
  • Rotatable Bond Count:1
  • Exact Mass:349.240564612
  • Heavy Atom Count:26
  • Complexity:636
Purity/Quality:

99.5%min *data from raw suppliers

7-KetoabirateroneAcetate *data from reagent suppliers

Safty Information:
  • Pictogram(s):  
  • Hazard Codes: 
MSDS Files:

SDS file from LookChem

Useful:
  • Drug Classes:Antineoplastic Agents
  • Canonical SMILES:CC12CCC(CC1=CCC3C2CCC4(C3CC=C4C5=CN=CC=C5)C)O
  • Isomeric SMILES:C[C@]12CC[C@@H](CC1=CC[C@@H]3[C@@H]2CC[C@]4([C@H]3CC=C4C5=CN=CC=C5)C)O
  • Recent ClinicalTrials:Serial Measurements of Molecular and Architectural Responses to Therapy (SMMART) PRIME Trial
  • Recent EU Clinical Trials:SPLASH: Study Evaluating Metastatic Castrate Resistant Prostate Cancer Treatment Using 177Lu-PNT2002 PSMA Therapy After Second-line Hormonal Treatment
  • Recent NIPH Clinical Trials:Study of Cabozantinib in Combination With Atezolizumab Versus Second NHT in Subjects With Metastatic Castration-Resistant Prostate Canc (mCRPC)
  • description Abiraterone is a new type of hormone therapy. It is also called abiraterone acetate, CB7630 or Zytiga. It is used to treat prostate cancer that has spread to other parts of the body. It may help some men to live longer. It can also help control symptoms. Clinical trials are also using abiraterone for earlier stages of prostate cancer and advanced breast cancer. Abiraterone is associated with a not uncommon rate of serum enzyme elevation during therapy, but has not been clearly linked to cases of clinically apparent liver injury with jaundice. On April 28, 2011, the U.S. Food and Drug Administration approved abiraterone acetate (Zytiga Tablets, Centocor Ortho Biotech, Inc.) for use in combination with prednisone for the treatment of patients with metastatic castration-resistant prostate cancer (mCRPC) who have received prior chemotherapy containing docetaxel. Abiraterone is a steroidal compound with antiandrogen activity. it is a Cytochrome P450 17A1 Inhibitor. The mechanism of action of abiraterone is as a Cytochrome P450 17A1 Inhibitor, and Cytochrome P450 2D6 Inhibitor, and Cytochrome P450 2C8 Inhibitor that catalyzes the 17alpha-hydroxylation of steroid intermediates involved in testosterone synthesis. Administration of this agent may suppress testosterone production by both the testes and the adrenals to castrate-range levels. figure 1: Zytiga (abiraterone acetate)
  • Uses Prasteronyl Abiraterone is a dimer impurity of Abiraterone (A108490), a steroidal cytochrome P 450 17α-hydroxylase-17,20-lyase inhibitor (CYP17), is currently undergoing phase II clinical trials as a potential drug for the treatment of androgen-dependent prostate cancer. Abiraterone, a steroidal cytochrome P 450 17α-hydroxylase-17,20-lyase inhibitor (CYP17), is currently undergoing phase II clinical trials as a potential drug for the treatment of androgen-dependent pr ostate cancer.
  • Therapeutic Function Antiandrogen
Technology Process of Abiraterone

There total 89 articles about Abiraterone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:
Guidance literature:
With lithium hydroxide monohydrate; In tetrahydrofuran; water; at 0 - 20 ℃; for 48h; Inert atmosphere;

Reference yield: 96.6%

Guidance literature:
With hydrogenchloride; In methanol; water; at 20 - 30 ℃; for 1.5h; pH=1 - 2;
Refernces Edit
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