5,10-dideaza-5,6,7,8-tetrahydroaminopterin

Base Information

Chemical Name:5,10-dideaza-5,6,7,8-tetrahydroaminopterin
CAS No.:95674-54-7
Molecular Formula:C21H26 N6 O5
Molecular Weight:442.47
Hs Code.:
Mol file:95674-54-7.mol

Synonyms:L-Glutamicacid, N-[4-[2-(2,4-diamino-1,5,6,7-tetrahydropyrido[2,3-d]pyrimidin-6-yl)ethyl]benzoyl]-(9CI); Pyrido[2,3-d]pyrimidine, L-glutamic acid deriv.

Suppliers and Price of 5,10-dideaza-5,6,7,8-tetrahydroaminopterin

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
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price

Total 3 raw suppliers

Chemical Property of 5,10-dideaza-5,6,7,8-tetrahydroaminopterin

Chemical Property:

Boiling Point:°Cat760mmHg
Flash Point:°C
PSA：193.55000
Density:1.393g/cm³
LogP:2.59710

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 5,10-dideaza-5,6,7,8-tetrahydroaminopterin

There total 11 articles about 5,10-dideaza-5,6,7,8-tetrahydroaminopterin which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

: 221469-31-4
2-(4-{2-[4-amino-2-(2,2-dimethyl-propionylamino)-5,6,7,8-tetrahydro-pyrido[2,3-d]pyrimidin-6-yl]-ethyl}-benzoylamino)-pentanedioic acid diethyl ester

: 95674-54-7
5,10-dideaza-5,6,7,8-tetrahydroaminopterin

Guidance literature:: With sodium hydroxide;
DOI:10.1016/S0960-894X(98)00683-0

Reference yield: 42.0%

: 95693-79-1
diethyl N-<4-<2-(2,4-diamino-5-deaza-5,6,7,8-tetrahydro-6-pteridyl)ethyl>benzoyl>-L-glutamate

: 95674-54-7
5,10-dideaza-5,6,7,8-tetrahydroaminopterin

Guidance literature:: With sodium hydroxide; In methanol; for 72h; Ambient temperature;
DOI:10.1021/jm00145a012

Reference yield:

: 80360-04-9
2,4-Diamino-6-(carboxaldehyde)pyrido[2,3-d]pyrimidine

: 95674-54-7
5,10-dideaza-5,6,7,8-tetrahydroaminopterin

Guidance literature:: Multi-step reaction with 3 steps

1: 34.5 percent / sodium hydride, N-methylpyrrolidone / 504 h / Ambient temperature

2: 0.1 g / TFA, H₂ / Pd/C / 24 h / 2844.3 Torr

3: 42 percent / 0.5 N NaOH / methanol / 72 h / Ambient temperature

With 1-methyl-pyrrolidin-2-one; sodium hydroxide; hydrogen; sodium hydride; trifluoroacetic acid; palladium on activated charcoal; In methanol;
DOI:10.1021/jm00145a012