221469-31-4Relevant academic research and scientific papers
The synthesis and biological activity of a series of 2,4- diaminopyrido[2,3-d]pyrimidine based antifolates as antineoplastic and antiarthritic agents
Gossett, Lynn S.,Habeck, Lillian L.,Shackelford, Katherine A.,Mendelsohn, Laurane G.,Gates, Susan B.,Worzalla, John F.,Self, Tracy D.,Theobald, Karla S.,Andis, Sherri L.,Schultz, Richard M.,Chuan, Shih
, p. 75 - 78 (2007/10/03)
A new series of 2,4-diaminopyrido[2,3-d]pyrimidine based antifolates 1- 3 were synthesized through an efficient conversion of 2-pivaloyl-4-oxo-6- ethynylpyrido[2,3-d]pyrimidine 5 to the corresponding 4-amino analog 7 via the activated 1,2,4-triazole inter
