2-Methoxy-4-propionylpyridine

Base Information

Chemical Name:2-Methoxy-4-propionylpyridine
CAS No.:880767-50-0
Molecular Formula:C₉H₁₁NO₂
Molecular Weight:165.192
Hs Code.:
DSSTox Substance ID:DTXSID40474882
Wikidata:Q82305039
Mol file:880767-50-0.mol

Synonyms:2-Methoxy-4-propionylpyridine;880767-50-0;1-(2-methoxypyridin-4-yl)propan-1-one;1-Propanone, 1-(2-methoxy-4-pyridinyl)-;SCHEMBL2799836;DTXSID40474882;OBPIFCWDBWHHBE-UHFFFAOYSA-N;1-(2-methoxy-pyridin-4-yl)-propan-1-one;FT-0724697;N14282

Suppliers and Price of 2-Methoxy-4-propionylpyridine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

American Custom Chemicals Corporation
2-METHOXY-4-PROPIONYLPYRIDINE 95.00%
5MG
$ 500.64

AccelPharmtech
1-(2-methoxy-4-pyridinyl)-1-Propanone 97.00%
25G
$ 4010.00

AccelPharmtech
1-(2-methoxy-4-pyridinyl)-1-Propanone 97.00%
5G
$ 2180.00

AccelPharmtech
1-(2-methoxy-4-pyridinyl)-1-Propanone 97.00%
1G
$ 1940.00

Total 3 raw suppliers

Chemical Property of 2-Methoxy-4-propionylpyridine

Chemical Property:

PSA：39.19000
LogP:1.68290
XLogP3:1.3
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:3
Exact Mass:165.078978594
Heavy Atom Count:12
Complexity:159

Purity/Quality:

98% ^*data from raw suppliers

2-METHOXY-4-PROPIONYLPYRIDINE 95.00% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:CCC(=O)C1=CC(=NC=C1)OC

Technology Process of 2-Methoxy-4-propionylpyridine

There total 2 articles about 2-Methoxy-4-propionylpyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

: 72716-86-0
4-cyano-2-methoxypyridine

: 2386-64-3
ethylmagnesium chloride

: 880767-50-0
1-(2-methoxypyridin-4-yl)propan-1-one

Guidance literature:: 4-cyano-2-methoxypyridine; ethylmagnesium chloride; In tetrahydrofuran; tert-butyl methyl ether; at 0 ℃; for 8.92h;

With water; In tetrahydrofuran; tert-butyl methyl ether; at 0 - 20 ℃; for 16h;

Reference yield:

: 33252-30-1
2-chloro-4-pyridinenitrile

: 880767-50-0
1-(2-methoxypyridin-4-yl)propan-1-one

Guidance literature:: Multi-step reaction with 2 steps

1: acetonitrile / 23 h / 20 °C

2: TBME / tetrahydrofuran / 4.5 h / 0 °C

With tert-butyl methyl ether; In tetrahydrofuran; acetonitrile;
DOI:10.1021/jo060928v

Reference yield:

: 880767-50-0
1-(2-methoxypyridin-4-yl)propan-1-one

: 220998-02-7
(R)-3-(3-benzyloxymethyl-2-methoxypyridin-4-yl)-3-hydroxypentanoic acid

Guidance literature:: Multi-step reaction with 6 steps

1.1: 62 percent / H₂SO₄; para-toluenesulfonic acid monohydrate / toluene / 72 h / Heating

2.1: 2-bromomesitylene; n-BuLi / tetrahydrofuran; hexane / 3.5 h / -10 - 20 °C

2.2: 68 percent / tetrahydrofuran; hexane / -23 - 20 °C

3.1: 88 percent / NaBH₄ / propan-2-ol; H₂O / 0.5 h / 0 °C

4.1: LHMDS / tetrahydrofuran / 0.58 h / -78 - 20 °C

4.2: Bu₄NI / tetrahydrofuran / 16 h / 65 °C

4.3: 96 percent / pyrrolidine / tetrahydrofuran / 3.5 h / 20 °C

5.1: 96 percent / PTSA*H₂O / ethanol; H₂O / 6.25 h / 80 °C

6.1: LHMDS / tetrahydrofuran / 2 h / -78 °C

6.2: tetrahydrofuran / 1.25 h / -95 - -78 °C

6.3: aq. LiOH; aq. H₂O₂ / tetrahydrofuran / 1.5 h / 0 - 20 °C

With sodium tetrahydroborate; n-butyllithium; 2,4,6-trimethylphenyl bromide; sulfuric acid; toluene-4-sulfonic acid; lithium hexamethyldisilazane; In tetrahydrofuran; ethanol; hexane; water; isopropyl alcohol; toluene;
DOI:10.1021/jo060928v