2-Methoxyisonicotinonitrile

Base Information

Chemical Name:2-Methoxyisonicotinonitrile
CAS No.:72716-86-0
Molecular Formula:C7H6 N2 O
Molecular Weight:134.14
Hs Code.:2933399090
European Community (EC) Number:689-875-3
DSSTox Substance ID:DTXSID20428404
Wikidata:Q72458472
Mol file:72716-86-0.mol

Synonyms:2-methoxyisonicotinonitrile;72716-86-0;4-CYANO-2-METHOXYPYRIDINE;2-methoxypyridine-4-carbonitrile;4-Pyridinecarbonitrile, 2-methoxy-;2-methoxy-4-cyanopyridine;2-methoxy-isonicotinonitrile;SCHEMBL447719;DTXSID20428404;NZAZWLSRKMDRNS-UHFFFAOYSA-N;MFCD06659893;2-(Methyloxy)-4-pyridinecarbonitrile;AKOS000198191;AC-9303;PB24932;PS-5443;AM804290;CS-0005483;FT-0646508;EN300-27263;A837601;J-509881;Z235344767

Suppliers and Price of 2-Methoxyisonicotinonitrile

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
4-Cyano-2-methoxypyridine
5g
$ 165.00

SynQuest Laboratories
4-Cyano-2-methoxypyridine 98%
100 g
$ 1200.00

SynQuest Laboratories
4-Cyano-2-methoxypyridine 98%
25 g
$ 400.00

SynQuest Laboratories
4-Cyano-2-methoxypyridine 98%
5 g
$ 136.00

Matrix Scientific
2-Methoxyisonicotinonitrile 97%
10g
$ 1428.00

Matrix Scientific
2-Methoxyisonicotinonitrile 97%
1g
$ 194.00

Frontier Specialty Chemicals
4-Cyano-2-methoxypyridine 97%
1g
$ 19.00

Frontier Specialty Chemicals
4-Cyano-2-methoxypyridine 97%
5g
$ 56.00

Crysdot
2-Methoxyisonicotinonitrile 97%
5g
$ 85.00

Chemenu
2-Methoxyisonicotinonitrile 97%
25g
$ 374.00

Total 40 raw suppliers

Chemical Property of 2-Methoxyisonicotinonitrile

Chemical Property:

Vapor Pressure:0.229mmHg at 25°C
Melting Point:88-92
Boiling Point:207.1oC at 760 mmHg
PKA:0.04±0.10(Predicted)
Flash Point:79.1oC
PSA：45.91000
Density:1.16g/cm3
LogP:0.96188
Storage Temp.:Inert atmosphere,Room Temperature
XLogP3:1.1
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:1
Exact Mass:134.048012819
Heavy Atom Count:10
Complexity:149

Purity/Quality:

99%, ^*data from raw suppliers

4-Cyano-2-methoxypyridine ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:Xi

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:COC1=NC=CC(=C1)C#N
Uses 4-Cyano-2-methoxypyridine is a reagent used in the synthesis of hydroxypyridone derivatives which are bioisosters of capsain.

Technology Process of 2-Methoxyisonicotinonitrile

There total 6 articles about 2-Methoxyisonicotinonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

: 33252-30-1
2-chloro-4-pyridinenitrile

: 124-41-4
sodium methylate

: 72716-86-0
4-cyano-2-methoxypyridine

Guidance literature:: In 1,4-dioxane; methanol; for 5h; Reflux;
DOI:10.1021/jm8005096

Reference yield: 51.0%

: 33252-30-1
2-chloro-4-pyridinenitrile

: 72716-86-0
4-cyano-2-methoxypyridine

Guidance literature:: With sodium; In methanol; methanoldioxan; water;

Reference yield: 45.0%

: 67-56-1
methanol

: 33252-30-1
2-chloro-4-pyridinenitrile

: 72716-86-0
4-cyano-2-methoxypyridine

Guidance literature:: methanol; With sodium hydride; In tetrahydrofuran; at 20 ℃; for 0.25h; Inert atmosphere;

2-chloro-4-pyridinenitrile; In tetrahydrofuran; at 20 ℃; for 3h; Inert atmosphere;
DOI:10.1021/jm500833f