2-(4-chlorophenyl)-4-thiazoleacetic acid ethyl ester

Base Information

• Chemical Name: 2-(4-chlorophenyl)-4-thiazoleacetic acid ethyl ester
• CAS No.: 20287-70-1
• Molecular Formula: C13H12 Cl N O2 S
• Molecular Weight: 281.763
• Hs Code.: 2934100090
• Mol file: 20287-70-1.mol

Synonyms:4-Thiazoleaceticacid, 2-(p-chlorophenyl)-, ethyl ester (8CI); Ethyl fenclozate

Chemical Property of 2-(4-chlorophenyl)-4-thiazoleacetic acid ethyl ester

Chemical Property:

• Vapor Pressure: 1.26E-06mmHg at 25°C
• Melting Point: 114-116℃
• Boiling Point: 400.6°C at 760 mmHg
• Flash Point: 196.1°C
• PSA: 67.43000
• Density: 1.288
• LogP: 3.56910

Purity/Quality:

98%,99%, ^*data from raw suppliers

Ethyl 2-(2-(4-chlorophenyl)thiazol-4-yl)acetate 95% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-(4-chlorophenyl)-4-thiazoleacetic acid ethyl ester

There total 6 articles about 2-(4-chlorophenyl)-4-thiazoleacetic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

4-bromo-3-ethoxy-2-butenoic acid ethyl ester (1116-50-3) + 4-chlorothiobenzamide (2521-24-6) → ethyl 2-(2-(4-chlorophenyl)thiazol-4-yl)acetate (20287-70-1)

Guidance literature:

With 1,1,1,3',3',3'-hexafluoro-propanol; sodium acetate; for 8h; Reflux;

DOI:10.1039/c7ra05993k

Reference yield: 89.4%

ethyl (2-chloroaceto)acetate (638-07-3) + 4-chlorothiobenzamide (2521-24-6) → ethyl 2-(2-(4-chlorophenyl)thiazol-4-yl)acetate (20287-70-1)

Guidance literature:

In ethanol; for 2h; Heating / reflux;

Reference yield: 69.0%

ethanol (64-17-5) + Methyl 4-chloroacetoacetate (32807-28-6,935731-94-5) + 4-chlorothiobenzamide (2521-24-6) → ethyl 2-(2-(4-chlorophenyl)thiazol-4-yl)acetate (20287-70-1)

Guidance literature:

With pyridine; for 6h; Heating;

DOI:10.1135/cccc20011809

upstream raw materials:

ethyl (2-chloroaceto)acetate

4-chlorothiobenzamide

ethanol

Methyl 4-chloroacetoacetate

Downstream raw materials:

2-(2-(4-chlorophenyl)thiazol-4-yl)acetonitrile

N-(2-(2-(4-chlorophenyl)thiazol-4-yl)ethyl)butyramide

2-(4-chlorophenyl)thiazole-4-carbaldehyde

Refernces

• 1、 Mhaske, Pravin C.,Shelke, Shivaji H.,Bhoye, Manish,Bobade, Vivek D.. "Synthesis and Antimicrobial Screening of 2-Aryl-5-((2-arylthiazol-4-yl)methyl)-1,3,4-oxadiazole Derivatives". . p. 1590 - 1597. Retrieved 2017/03/27.
• 2、 Mhaske, Pravin C.,Shelke, Shivaji H.,Gadge, Kisan,Shinde, Abhijit. "Synthesis and Antifungal Screening of 2-(2-Aryl-4-methyl-thiazol-5-yl)-5-((2-aryl/benzylthiazol-4-yl)methyl)-1,3,4-oxadiazole Derivatives". . p. 129 - 134. Retrieved 2015/03/04.