A-BROMO-1-[(1,1-DIMETHYLETHOXY)CARBONYL]-4-PIPERIDINEACETIC ACID

Base Information

Chemical Name:A-BROMO-1-[(1,1-DIMETHYLETHOXY)CARBONYL]-4-PIPERIDINEACETIC ACID
CAS No.:881016-89-3
Molecular Formula:C₁₂H₂₀BrNO₄
Molecular Weight:322.199
Hs Code.:2933399090
Mol file:881016-89-3.mol

Synonyms:4-(bromo-carboxy-methyl)-piperidine-1-carboxylic acid tert-butyl ester;A-BROMO-1-[(1,1-DIMETHYLETHOXY)CARBONYL]-4-PIPERIDINEACETIC ACID;

Suppliers and Price of A-BROMO-1-[(1,1-DIMETHYLETHOXY)CARBONYL]-4-PIPERIDINEACETIC ACID

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

American Custom Chemicals Corporation
ALPHA-BROMO-1-[(1,1-DIMETHYLETHOXY)CARBONYL]-4-PIPERIDINEACETIC ACID 95.00%
5MG
$ 499.76

Total 5 raw suppliers

Chemical Property of A-BROMO-1-[(1,1-DIMETHYLETHOXY)CARBONYL]-4-PIPERIDINEACETIC ACID

Chemical Property:

PSA：66.84000
LogP:2.41950

Purity/Quality:

≥99% ^*data from raw suppliers

ALPHA-BROMO-1-[(1,1-DIMETHYLETHOXY)CARBONYL]-4-PIPERIDINEACETIC ACID 95.00% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of A-BROMO-1-[(1,1-DIMETHYLETHOXY)CARBONYL]-4-PIPERIDINEACETIC ACID

There total 5 articles about A-BROMO-1-[(1,1-DIMETHYLETHOXY)CARBONYL]-4-PIPERIDINEACETIC ACID which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 66.0%

: 881016-88-2
4-(bromo-methoxycarbonyl-methyl)-piperidine-1-carboxylic acid tert-butyl ester

: 881016-89-3
4-(bromo-carboxy-methyl)-piperidine-1-carboxylic acid tert-butyl ester

Guidance literature:: With lithium hydroxide; In tetrahydrofuran; methanol; at 20 ℃;
DOI:10.1021/jm070902b

Reference yield:

: C₁₂H₁₉BrNO₄^(1-)*Li⁽¹⁺⁾

: 881016-89-3
4-(bromo-carboxy-methyl)-piperidine-1-carboxylic acid tert-butyl ester

Guidance literature:: With hydrogenchloride; In water;

Reference yield:

: 168986-49-0
4-piperidine acetic acid methyl ester

: 881016-89-3
4-(bromo-carboxy-methyl)-piperidine-1-carboxylic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 3 steps

1.1: triethylamine / dichloromethane / 3 h / 0 - 20 °C

2.1: lithium hexamethyldisilazane / tetrahydrofuran / 4 h / -78 °C

2.2: 2.5 h / -78 - 0 °C

3.1: lithium hydroxide; water / methanol; tetrahydrofuran / 3 h / 20 °C

With water; triethylamine; lithium hydroxide; lithium hexamethyldisilazane; In tetrahydrofuran; methanol; dichloromethane;