1H-1,4-Benzodiazepine-2,5-dione, 7-(4-fluorophenoxy)-3,4-dihydro-4-[(1R)-1-(hydroxymethyl)-2-methylprop yl]-

Base Information

• Chemical Name: 1H-1,4-Benzodiazepine-2,5-dione, 7-(4-fluorophenoxy)-3,4-dihydro-4-[(1R)-1-(hydroxymethyl)-2-methylprop yl]-
• CAS No.: 881211-01-4
• Molecular Formula: C20H21FN2O4
• Molecular Weight: 372.396

Synonyms:

Chemical Property of 1H-1,4-Benzodiazepine-2,5-dione, 7-(4-fluorophenoxy)-3,4-dihydro-4-[(1R)-1-(hydroxymethyl)-2-methylprop yl]-

Chemical Property:

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MSDS Files:

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Technology Process of 1H-1,4-Benzodiazepine-2,5-dione, 7-(4-fluorophenoxy)-3,4-dihydro-4-[(1R)-1-(hydroxymethyl)-2-methylprop yl]-

There total 1 articles about 1H-1,4-Benzodiazepine-2,5-dione, 7-(4-fluorophenoxy)-3,4-dihydro-4-[(1R)-1-(hydroxymethyl)-2-methylprop yl]- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

C20H19FN2O5 (881211-00-3) → C20H21FN2O4 (881211-01-4)

Guidance literature:

C₂₀H₁₉FN₂O₅; With diazomethyl-trimethyl-silane; In tetrahydrofuran; for 3h;

With lithium aluminium tetrahydride; In tetrahydrofuran; for 0.5h;

With sodium hydrogencarbonate; In tetrahydrofuran;

Reference yield:

C20H21FN2O4 (881211-01-4) + 4-Nitrophenyl chloroformate (7693-46-1) → C27H24FN3O8 (881211-49-0)

Guidance literature:

C₂₀H₂₁FN₂O₄; 4-Nitrophenyl chloroformate; With 4-methyl-morpholine; In dichloromethane; at 0 ℃; for 3h;

With sodium hydrogencarbonate; In dichloromethane;

Reference yield:

C20H21FN2O4 (881211-01-4) + N-benzylpiperidine-4-carboxylic acid (10315-07-8) → 1-benzyl-piperidine-4-carboxylic acid (R)-2-[7-(4-fluoro-phenoxy)-2,5-dioxo-1,2,3,5-tetrahydro-benzo[e][1,4]diazepin-4-yl]-3-methyl-butyl ester

Guidance literature:

C₂₀H₂₁FN₂O₄; N-benzylpiperidine-4-carboxylic acid; With 4-methyl-morpholine; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane; at 20 ℃; for 8h;

With water; sodium hydrogencarbonate; In dichloromethane;

upstream raw materials:

C₂₀H₁₉FN₂O₅

Downstream raw materials:

C₂₇H₂₄FN₃O₈

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