6-BROMO-1-PHENYLSULFONYL-3-CHLOROSULFONYLINDOL

Base Information

• Chemical Name: 6-BROMO-1-PHENYLSULFONYL-3-CHLOROSULFONYLINDOL
• CAS No.: 881406-31-1
• Molecular Formula: C₁₄H₉BrClNO₄S₂
• Molecular Weight: 434.719
• Hs Code.: 2933990090
• Mol file: 881406-31-1.mol

Synonyms:I10-1076;6-Bromo-1-phenylsulfonyl-3-chlorosulfonylindol;

Chemical Property of 6-BROMO-1-PHENYLSULFONYL-3-CHLOROSULFONYLINDOL

Chemical Property:

• Melting Point: 187.5-189 °C(Solv: acetonitrile (75-05-8))
• Boiling Point: 603.2±58.0 °C(Predicted)
• PSA: 89.97000
• Density: 1.76±0.1 g/cm3(Predicted)
• LogP: 5.72990
• Storage Temp.: 2-8°C

Purity/Quality:

97% ^*data from raw suppliers

6-Bromo-1-phenylsulfonyl-3-chlorosulfonylindol ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 6-BROMO-1-PHENYLSULFONYL-3-CHLOROSULFONYLINDOL

There total 3 articles about 6-BROMO-1-PHENYLSULFONYL-3-CHLOROSULFONYLINDOL which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

1‐(benzenesulfonyl)‐6‐bromo‐1H‐indole (679794-03-7) → 6-bromo-1-phenylsulfonyl-1H-indole-3-sulfonyl chloride (881406-31-1)

Guidance literature:

With chlorosulfonic acid; In acetonitrile; at 20 ℃; for 75.5h;

DOI:10.1016/j.tet.2005.11.062

Reference yield:

6-bromo-1H-indole (52415-29-9) → 6-bromo-1-phenylsulfonyl-1H-indole-3-sulfonyl chloride (881406-31-1)

Guidance literature:

Multi-step reaction with 2 steps

1: 97 percent / NaOH; tetrabutylammonium hydrogen sulfate / CH₂Cl₂ / 3 h / 0 - 20 °C

2: 88 percent / chlorosulfonic acid / acetonitrile / 75.5 h / 20 °C

With chlorosulfonic acid; sodium hydroxide; tetra(n-butyl)ammonium hydrogensulfate; In dichloromethane; acetonitrile;

DOI:10.1016/j.tet.2005.11.062

Reference yield:

benzenesulfonyl chloride (98-09-9) → 6-bromo-1-phenylsulfonyl-1H-indole-3-sulfonyl chloride (881406-31-1)

Guidance literature:

Multi-step reaction with 2 steps

1: 97 percent / NaOH; tetrabutylammonium hydrogen sulfate / CH₂Cl₂ / 3 h / 0 - 20 °C

2: 88 percent / chlorosulfonic acid / acetonitrile / 75.5 h / 20 °C

With chlorosulfonic acid; sodium hydroxide; tetra(n-butyl)ammonium hydrogensulfate; In dichloromethane; acetonitrile;

DOI:10.1016/j.tet.2005.11.062

upstream raw materials:

1‐(benzenesulfonyl)‐6‐bromo‐1H‐indole

6-bromo-1H-indole

benzenesulfonyl chloride