Carbamic acid, [1-(2-aminophenyl)-4-[(tetrahydro-2H-pyran-2-yl)oxy]butyl]methyl-, 1,1-dimethylethyl ester

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Chemical Name:Carbamic acid, [1-(2-aminophenyl)-4-[(tetrahydro-2H-pyran-2-yl)oxy]butyl]methyl-, 1,1-dimethylethyl ester
CAS No.:881417-08-9
Molecular Formula:C21H34N2O4
Molecular Weight:378.512
Hs Code.:

Synonyms:

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Chemical Property of Carbamic acid, [1-(2-aminophenyl)-4-[(tetrahydro-2H-pyran-2-yl)oxy]butyl]methyl-, 1,1-dimethylethyl ester

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Technology Process of Carbamic acid, [1-(2-aminophenyl)-4-[(tetrahydro-2H-pyran-2-yl)oxy]butyl]methyl-, 1,1-dimethylethyl ester

There total 12 articles about Carbamic acid, [1-(2-aminophenyl)-4-[(tetrahydro-2H-pyran-2-yl)oxy]butyl]methyl-, 1,1-dimethylethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 881417-07-8
2-[1-(N-methyl-tert-butoxycarbonylamino)-4-(tetrahydropyran-2-yloxy)butyl]nitrobenzene

: 881417-08-9
2-[1-(N-methyl-tert-butoxycarbonylamino)-4-(tetrahydropyran-2-yloxy)butyl]aniline

Guidance literature:: With platinum(IV) oxide; hydrogen; In ethanol; at 20 ℃; for 2h;
DOI:10.3987/COM-05-S(K)58

Reference yield:

: 110-87-2
3,4-dihydro-2H-pyran

: 881417-08-9
2-[1-(N-methyl-tert-butoxycarbonylamino)-4-(tetrahydropyran-2-yloxy)butyl]aniline

Guidance literature:: Multi-step reaction with 8 steps

1: 95 percent / pyridinium p-toluenesulfonate / CH₂Cl₂ / 15 h / 20 °C

2: 97 percent / tetra-n-butylammonium fluoride / tetrahydrofuran / 6 h / 20 °C

3: 86 percent / diethyl azodicarboxylate; diphenylphosphoryl azide; PPh₃ / tetrahydrofuran / 2 h / 0 °C

4: tetrahydrofuran / 13 h / 20 °C

5: H₂O / tetrahydrofuran / 3.5 h / 60 °C

6: 4.2 g / tetrahydrofuran; H₂O / 2.5 h / 20 °C

7: 97 percent / NaH / tetrahydrofuran / 6 h / 0 - 20 °C

8: 100 percent / PtO₂; H₂ / ethanol / 2 h / 20 °C

With platinum(IV) oxide; diphenylphosphoranyl azide; tetrabutyl ammonium fluoride; water; hydrogen; pyridinium p-toluenesulfonate; sodium hydride; triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran; ethanol; dichloromethane; water; 3: Mitsunobu reaction;
DOI:10.3987/COM-05-S(K)58

Reference yield:

: 881416-99-5
2-(1-tert-butyldimethylsilylbut-3-enyl)nitrobenzene

: 881417-08-9
2-[1-(N-methyl-tert-butoxycarbonylamino)-4-(tetrahydropyran-2-yloxy)butyl]aniline

Guidance literature:: Multi-step reaction with 10 steps

1: BH₃*THF / tetrahydrofuran / 7 h / 0 °C

2: 21.5 g / H₂O₂; NaOH / H₂O / 0 - 20 °C

3: 95 percent / pyridinium p-toluenesulfonate / CH₂Cl₂ / 15 h / 20 °C

4: 97 percent / tetra-n-butylammonium fluoride / tetrahydrofuran / 6 h / 20 °C

5: 86 percent / diethyl azodicarboxylate; diphenylphosphoryl azide; PPh₃ / tetrahydrofuran / 2 h / 0 °C

6: tetrahydrofuran / 13 h / 20 °C

7: H₂O / tetrahydrofuran / 3.5 h / 60 °C

8: 4.2 g / tetrahydrofuran; H₂O / 2.5 h / 20 °C

9: 97 percent / NaH / tetrahydrofuran / 6 h / 0 - 20 °C

10: 100 percent / PtO₂; H₂ / ethanol / 2 h / 20 °C

With platinum(IV) oxide; sodium hydroxide; borane-THF; diphenylphosphoranyl azide; tetrabutyl ammonium fluoride; water; hydrogen; dihydrogen peroxide; pyridinium p-toluenesulfonate; sodium hydride; triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran; ethanol; dichloromethane; water; 5: Mitsunobu reaction;
DOI:10.3987/COM-05-S(K)58