2-(1-tert-butyldimethylsilyloxy-4-hydroxybutyl)nitrobenzene

Base Information

• Chemical Name: 2-(1-tert-butyldimethylsilyloxy-4-hydroxybutyl)nitrobenzene
• CAS No.: 881417-00-1
• Molecular Formula: C₁₆H₂₇NO₄Si
• Molecular Weight: 325.48
• Mol file: 881417-00-1.mol

Synonyms:2-(1-tert-butyldimethylsilyloxy-4-hydroxybutyl)nitrobenzene

Chemical Property of 2-(1-tert-butyldimethylsilyloxy-4-hydroxybutyl)nitrobenzene

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-(1-tert-butyldimethylsilyloxy-4-hydroxybutyl)nitrobenzene

There total 4 articles about 2-(1-tert-butyldimethylsilyloxy-4-hydroxybutyl)nitrobenzene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4-(tert-butyl-dimethyl-silanyloxy)-4-(2-nitro-phenyl)-butyl-borane → 2-(1-tert-butyldimethylsilyloxy-4-hydroxybutyl)nitrobenzene (881417-00-1)

Guidance literature:

With sodium hydroxide; dihydrogen peroxide; In water; at 0 - 20 ℃;

DOI:10.3987/COM-05-S(K)58

Reference yield:

2-(1-tert-butyldimethylsilylbut-3-enyl)nitrobenzene (881416-99-5) → 2-(1-tert-butyldimethylsilyloxy-4-hydroxybutyl)nitrobenzene (881417-00-1)

Guidance literature:

Multi-step reaction with 2 steps

1: BH₃*THF / tetrahydrofuran / 7 h / 0 °C

2: 21.5 g / H₂O₂; NaOH / H₂O / 0 - 20 °C

With sodium hydroxide; borane-THF; dihydrogen peroxide; In tetrahydrofuran; water;

DOI:10.3987/COM-05-S(K)58

Reference yield:

1-(2-nitrophenyl)but-3-en-1-ol (125715-24-4) → 2-(1-tert-butyldimethylsilyloxy-4-hydroxybutyl)nitrobenzene (881417-00-1)

Guidance literature:

Multi-step reaction with 3 steps

1: 90 percent / imidazole / dimethylformamide / 12 h / 20 °C

2: BH₃*THF / tetrahydrofuran / 7 h / 0 °C

3: 21.5 g / H₂O₂; NaOH / H₂O / 0 - 20 °C

With 1H-imidazole; sodium hydroxide; borane-THF; dihydrogen peroxide; In tetrahydrofuran; water; N,N-dimethyl-formamide;

DOI:10.3987/COM-05-S(K)58

upstream raw materials:

2-(1-tert-butyldimethylsilylbut-3-enyl)nitrobenzene

1-(2-nitrophenyl)but-3-en-1-ol

tert-butyldimethylsilyl chloride

Downstream raw materials:

2-[1-tert-butyldimethylsilyloxy-4-(tetrahydropyran-2-yloxy)butyl]nitrobenzene

2-[1-hydroxy-4-(tetrahydropyran-2-yloxy)butyl]nitrobenzene

2-[1-azido-4-(tetrahydropyran-2-yloxy)butyl]nitrobenzene

N-[2-(4-hydroxy-1-oxobutyl)phenyl]-p-toluenesulfonamide