Propanoic acid, 2-[[4-[[(6-chloro-4-pyrimidinyl)[(2-methyl-4-thiazolyl)methyl]amino]methyl] phenyl]thio]-2-methyl-, 1,1-dimethylethyl ester

Base Information

Chemical Name:Propanoic acid, 2-[[4-[[(6-chloro-4-pyrimidinyl)[(2-methyl-4-thiazolyl)methyl]amino]methyl] phenyl]thio]-2-methyl-, 1,1-dimethylethyl ester
CAS No.:881687-58-7
Molecular Formula:C24H29ClN4O2S2
Molecular Weight:505.105
Hs Code.:

Propanoic acid,
2-[[4-[[(6-chloro-4-pyrimidinyl)[(2-methyl-4-thiazolyl)methyl]amino]methyl]
phenyl]thio]-2-methyl-, 1,1-dimethylethyl ester

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Chemical Property of Propanoic acid, 2-[[4-[[(6-chloro-4-pyrimidinyl)[(2-methyl-4-thiazolyl)methyl]amino]methyl] phenyl]thio]-2-methyl-, 1,1-dimethylethyl ester

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Technology Process of Propanoic acid, 2-[[4-[[(6-chloro-4-pyrimidinyl)[(2-methyl-4-thiazolyl)methyl]amino]methyl] phenyl]thio]-2-methyl-, 1,1-dimethylethyl ester

There total 1 articles about Propanoic acid, 2-[[4-[[(6-chloro-4-pyrimidinyl)[(2-methyl-4-thiazolyl)methyl]amino]methyl] phenyl]thio]-2-methyl-, 1,1-dimethylethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

: 1193-21-1
4,6-dichloropyrimidine

: 881687-57-6
tert-butyl-2-methyl-2-{[4-({[(2-methyl-1,3-thiazol-4-yl)methyl]amino}methyl)phenyl]thio}-propanoate

: 881687-58-7
tert-butyl-2-{[4-({(6-chloropyrimidm-4-yl)[(2-methyl-1,3-thiazol-4-yl)methyl]amino}methyl)-phenyl]thio}-2-methylpropanoate

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In isopropyl alcohol; Heating / reflux;

Reference yield: 64.0%

: 881687-58-7
tert-butyl-2-{[4-({(6-chloropyrimidm-4-yl)[(2-methyl-1,3-thiazol-4-yl)methyl]amino}methyl)-phenyl]thio}-2-methylpropanoate

: 98-17-9
3-Trifluoromethylphenol

: tert-butyl-2-methyl-2-({4-[([(2-methyl-1,3-thiazol-4-yl)methyl]{6-[3-(trifluoromethyl)phenoxy]-pyrimidin-4-yl}amino)methyl]phenyl}thio)propanoate

Guidance literature:: With potassium carbonate; copper(II) oxide; In pyridine; at 150 ℃;

Reference yield: 22.0%

: 881687-58-7
tert-butyl-2-{[4-({(6-chloropyrimidm-4-yl)[(2-methyl-1,3-thiazol-4-yl)methyl]amino}methyl)-phenyl]thio}-2-methylpropanoate

: trans-4-methoxycyclohexanol

: 2-{[4-({{6-[(trans-4-methoxycyclohexyl)oxy]pyrimidin-4-yl}[(2-methyl-1,3-thiazol-4-yl)methyl]-amino}methyl)phenyl]thio}-2-methylpropanoic acid

Guidance literature:: trans-4-methoxycyclohexanol; With potassium tert-butylate; at 20 ℃; for 0.25h;

tert-butyl-2-{[4-({(6-chloropyrimidm-4-yl)[(2-methyl-1,3-thiazol-4-yl)methyl]amino}methyl)-phenyl]thio}-2-methylpropanoate; at 20 ℃;

With trifluoroacetic acid; In dichloromethane; at 20 ℃; for 2h;