98-17-9

Basic information

• Product Name: 3-Trifluoromethylphenol
• Synonyms: META-HYDROXYBENZOTRIFLUORIDE;3-HYDROXYBENZOTRIFLUORID 99%;PHENOL,3-(TRIFLUOROMETHYL);α,α,α-Trifluoro-m-cresol, 3-Hydroxybenzotrifluoride;3-(Trifluoromethyl) phenol ,98%;3-(Trifluoromethyl)phenol,α,α,α-Trifluoro-m-cresol, 3-Hydroxybenzotrifluoride;3-Trifluoromethylphe;alpha,alpha,alpha-Trifluoro-M-cresol, 98+% 25ML
• CAS NO: 98-17-9
• Molecular Formula: C₇H₅F₃O
• Molecular Weight: 162.11
• EINECS: 202-645-5
• Product Categories: Aromatic Phenols;alcohol;Trifluoromethylbenzene serise
• Mol File: 98-17-9.mol
• Article Data: 69

Chemical Properties

• Melting Point: −2-−1.8 °C(lit.)
• Boiling Point: 178-179 °C(lit.)
• Flash Point: 165 °F
• Appearance: Clear yellow/Liquid
• Density: 1.333 g/mL at 25 °C(lit.)
• Vapor Pressure: 0.56 mm Hg ( 40 °C)
• Refractive Index: n20/D 1.458(lit.)
• Storage Temp.: 2-8°C
• PKA: 8.68(at 25℃)
• Water Solubility: insoluble
• BRN: 2045663
• CAS DataBase Reference: 3-Trifluoromethylphenol(CAS DataBase Reference)
• NIST Chemistry Reference: 3-Trifluoromethylphenol(98-17-9)
• EPA Substance Registry System: 3-Trifluoromethylphenol(98-17-9)

Safety Data

• Hazard Codes: Xi,T
• Statements: 37/38-41-34-24/25-36/37/38
• Safety Statements: 26-39-45-36/37/39
• WGK Germany: 3
• RTECS: GP3510000
• TSCA: T
• HazardClass: TOXIC
• Hazardous Substances Data: 98-17-9(Hazardous Substances Data)

Usage

Uses

Different sources of media describe the Uses of 98-17-9 differently. You can refer to the following data:
1. 5-Trifluoromethylphenol, is a versatile buidiling block used for the synthesis of various chemical compounds, including pesticides. It can be utilized for the preparation of potassium methyl 1-(substituted phenoxyacetoxy)alkylphosphonatehaving herbicidal activities.
2. 3-(Trifluoromethyl)phenol (3-Hydroxybenzotrifluoride) was used in the preparation of travoprost (antiglaucoma agent).

InChI:InChI=1/C7H5F3O/c8-7(9,10)5-2-1-3-6(11)4-5/h1-4,11H

Synthetic route

3-trifluoromethylaniline (98-16-8) → 3-Trifluoromethylphenol (98-17-9)

Conditions	Yield
Stage #1: 3-trifluoromethylaniline With sulfuric acid; sodium nitrite at 5 - 20℃; for 1h; Stage #2: With water Reflux;	94%
With sulfuric acid; sodium nitrite at 12.5 - 88℃; Temperature; Reagent/catalyst;	93.6%
Stage #1: 3-trifluoromethylaniline With sulfuric acid at 83℃; for 1h; Stage #2: With sodium nitrite In water at -3℃; for 1h; Stage #3: With sulfuric acid; copper(II) sulfate In water at 125℃; Temperature;	92%

m-trifluoromethylphenyl iodide (401-81-0) → 3-Trifluoromethylphenol (98-17-9)

Conditions	Yield
With tetra(n-butyl)ammonium hydroxide In water; dimethyl sulfoxide at 165℃; for 0.0833333h; Flow reactor;	90%
With copper acetylacetonate; N1-(4-hydroxy-2,6-dimethylphenyl)-N2-(4-hydroxy-3,5-dimethylphenyl)oxalamide; potassium hydroxide In water; dimethyl sulfoxide at 60℃; for 24h; Schlenk technique; Inert atmosphere;	90%
With copper(l) iodide; 8-quinolinol; potassium hydroxide In water; dimethyl sulfoxide; tert-butyl alcohol at 100℃; for 48h; Inert atmosphere;	88%

(meta-(trifluoromethyl)phenyl)boronic acid (1423-26-3) → 3-Trifluoromethylphenol (98-17-9)

Conditions	Yield
With copper(II) ferrite; water; sodium hydroxide at 40℃; for 24h; Green chemistry;	96%
With oxygen; triethylamine In 2-methyltetrahydrofuran at 20℃; under 760.051 Torr; for 24h; Green chemistry;	96%
With dihydrogen peroxide In water at 20℃; for 0.166667h; Green chemistry;	92%

1-but-3-enoxy-3-(trifluoromethyl)benzene → 3-Trifluoromethylphenol (98-17-9)

Conditions	Yield
With [2,2]bipyridinyl; (1,2-dimethoxyethane)dichloronickel(II); water; bis(pinacol)diborane; lithium tert-butoxide In methanol; N,N-dimethyl acetamide at 30℃; for 24h; Schlenk technique;	67%
With 6,6'-dimethyl-2,2'-bipyridine; (1,2-dimethoxyethane)dichloronickel(II); bis(pinacol)diborane; lithium tert-butoxide In methanol; N,N-dimethyl acetamide; water at 30℃; for 24h; Inert atmosphere; Glovebox; Sealed tube;	67%

C12H13F3O → 3-Trifluoromethylphenol (98-17-9)

Conditions	Yield
With [2,2]bipyridinyl; (1,2-dimethoxyethane)dichloronickel(II); water; bis(pinacol)diborane; lithium tert-butoxide In methanol; N,N-dimethyl acetamide at 30℃; for 24h; Schlenk technique;	63%
With 6,6'-dimethyl-2,2'-bipyridine; (1,2-dimethoxyethane)dichloronickel(II); bis(pinacol)diborane; lithium tert-butoxide In methanol; N,N-dimethyl acetamide; water at 30℃; for 24h; Inert atmosphere; Glovebox; Sealed tube;	63%

1-(benzyloxy)-3-(trifluoromethyl)benzene (70097-64-2) → 3-Trifluoromethylphenol (98-17-9)

Conditions	Yield
With 1-n-butyl-3-methylimidazolim bromide at 200 - 220℃; for 0.0833333h; Microwave irradiation; Inert atmosphere;	98%

3-hydroxyphenylboronic acid (87199-18-6) + Umemoto's reagent (129946-88-9) → 3-Trifluoromethylphenol (98-17-9)

Conditions	Yield
With 2,4,6-trimethyl-pyridine; copper diacetate In N,N-dimethyl acetamide at 0℃; under 760.051 Torr; for 16h; Inert atmosphere;	60%

meta-trifluoromethylphenyl N,N-diethylcarbamate (1245824-29-6) → 3-Trifluoromethylphenol (98-17-9)

Conditions	Yield
With zirconocene dichloride In tetrahydrofuran at 20℃; Inert atmosphere;	91%

3-chlorotrifluoromethylbenzene (98-15-7) → 3-Trifluoromethylphenol (98-17-9)

Conditions	Yield
With copper acetylacetonate; N1-(4-hydroxy-2,6-dimethylphenyl)-N2-(4-hydroxy-3,5-dimethylphenyl)oxalamide; water In water; dimethyl sulfoxide at 130℃; for 24h; Schlenk technique; Inert atmosphere;	93%
With 5-(di-tert-butylphosphino)-1′, 3′, 5′-triphenyl-1′H-[1,4′]bipyrazole; tris-(dibenzylideneacetone)dipalladium(0); cesiumhydroxide monohydrate In tetrahydrofuran at 65℃; Inert atmosphere; Glovebox; Sealed tube;	86%
Multi-step reaction with 2 steps 1: 2-methyl-8-hydroxyquinoline copper; sodium hydroxide / methanol / 5 h / 100 - 105 °C / 6000.6 - 7500.75 Torr / Autoclave 2: methanol / 35 - 40 °C / Autoclave View Scheme

3-trifluoromethyl-2-cyclohexene-1-one (74031-45-1) → 3-Trifluoromethylphenol (98-17-9)

Conditions	Yield
With tetrakis(acetonitrile)palladium(II) bis(tetrafluoroborate); 6,6'-dimethyl-2,2'-bipyridine; sodium anthraquinone-2-sulfonate; oxygen In water; dimethyl sulfoxide at 80℃; under 760.051 Torr; for 12h;	68%

4-chloro-3-trifluoromethylphenol (6294-93-5) → 3-Trifluoromethylphenol (98-17-9)

Conditions	Yield
With hydrogen In ethanol
With hydrogen In ethanol

(3-trifluoromethylphenyl)(phenyl)iodonium triflate → 3-Trifluoromethylphenol (98-17-9)

Conditions	Yield
With dihydrogen peroxide; sodium iodide; sodium hydroxide In methanol at 20℃; for 1h; Microwave irradiation;	47%

3-bromo-1-trifluoromethylbenzene (401-78-5) → 3-Trifluoromethylphenol (98-17-9)

Conditions	Yield
With copper acetylacetonate; N1-(4-hydroxy-2,6-dimethylphenyl)-N2-(4-hydroxy-3,5-dimethylphenyl)oxalamide; water In water; dimethyl sulfoxide at 80℃; for 24h; Schlenk technique; Inert atmosphere;	84%
Multi-step reaction with 2 steps 1: 2-methyl-8-hydroxyquinoline copper; sodium hydroxide / methanol / 2 h / 100 - 105 °C / 6000.6 - 7500.75 Torr / Autoclave 2: methanol / 35 - 40 °C / Autoclave View Scheme

[3-(trifluoromethyl)phenyl](2,4,6-trimethylphenyl)iodonium trifluoromethanesulfonate (1204518-08-0) → 3-Trifluoromethylphenol (98-17-9)

Conditions	Yield
With water; sodium acetate; copper(l) chloride In N,N-dimethyl-formamide at 40℃; for 2h; Inert atmosphere; Sealed tube;	75%

cis-1,2-dihydroxy-3-trifluoromethyl-cyclohexa-3,5-diene (131101-28-5) → 3-Trifluoromethylphenol (98-17-9)

Conditions	Yield
With sodium hydroxide In water at 25℃; Kinetics; Concentration;	100%

sodium 3-(trifluoromethyl)phenolate → 3-Trifluoromethylphenol (98-17-9)

Conditions	Yield
In methanol at 35 - 40℃; Autoclave;	156.8 g

3-(trifluoromethyl)phenol ABA ester → 3-Trifluoromethylphenol (98-17-9) + Abscisic acid (2228-72-0, 6755-41-5, 7773-56-0, 14375-45-2, 14398-53-9, 14674-85-2, 40331-02-0, 52392-36-6, 72029-68-6, 72029-69-7, 113349-29-4, 21293-29-8)

Conditions	Yield
With water at 30℃; for 168h; Sealed tube; Irradiation;

α,α,α-trifluorotoluene (98-08-8) → 4-hydroxybenzotrifluoride (402-45-9) + 2-(trifluoromethyl)phenol (444-30-4) + 3-Trifluoromethylphenol (98-17-9)

Conditions	Yield
With tert.-butylnitrite; water; oxygen; 2,3-dicyano-5,6-dichloro-p-benzoquinone In neat (no solvent) at 24.84℃; Inert atmosphere; Irradiation; Overall yield = 8 %;
With oxygen; ascorbic acid In water; acetic acid at 105℃; under 11251.1 Torr; for 11h; Overall yield = 14 %;
Stage #1: α,α,α-trifluorotoluene With 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical; 2-(t-butylazo)prop-2-yl hydroperoxide In benzene at 44.84℃; Stage #2: With N,O-Bis(trimethylsilyl)trifluoroacetamide at 75℃; for 2h; Temperature; Solvent; Inert atmosphere; regioselective reaction;

→ 3-Trifluoromethylphenol (98-17-9)

Conditions	Yield
With bis(benzonitrile)palladium(II) dichloride In benzene for 20h; Heating;	93%

3-(trifluoromethyl)anisole (454-90-0) → 3-Trifluoromethylphenol (98-17-9)

Conditions	Yield
With 1-n-butyl-3-methylimidazolim bromide at 220℃; for 1h; Inert atmosphere; Microwave irradiation;	94%

3-trifluoromethyl-1-(diethoxymethylsilyl)benzene (1763-87-7) → 3-Trifluoromethylphenol (98-17-9)

Conditions	Yield
With potassium fluoride; dihydrogen peroxide In ethanol for 18h; Heating;	60%

C7H4F3N2O(1+)*BF4(1-) → 3-Trifluoromethylphenol (98-17-9) + 4-fluoro-3-(trifluoromethyl)phenol (61721-07-1)

Conditions	Yield
With pyridine; hydrogen fluoride for 3.33333h; Decomposition; Fluoro-dediazoniation; Irradiation;	A 0.1% B 83.8%
With pyridine; hydrogen fluoride at 140℃; Decomposition; Fluoro-dediazoniation;	A 1.1% B 2.5%

4-trifluoromethylphenylamine (455-14-1) → 3-Trifluoromethylphenol (98-17-9)

Conditions

Yield

Multi-step reaction with 6 steps 1.1: dichloromethane; water / 1 h / 25 °C 2.1: sulfuric acid; nitric acid / 2 h / 28 °C 3.1: sulfuric acid / 5 h / 80 °C 4.1: sulfuric acid; acetic acid / water / 2 h / 35 °C 4.2: 3 h / -3 °C 5.1: hydrogen; palladium on activated charcoal / methanol / 4 h / 30 °C / 3750.38 - 13501.4 Torr / Autoclave 6.1: sulfuric acid / 1 h / 83 °C 6.2: 1 h / -3 °C 6.3: 125 °C View Scheme

4-(trifluromethyl)acetanilide (349-97-3) → 3-Trifluoromethylphenol (98-17-9)

Conditions	Yield
Multi-step reaction with 5 steps 1.1: sulfuric acid; nitric acid / 2 h / 28 °C 2.1: sulfuric acid / 5 h / 80 °C 3.1: sulfuric acid; acetic acid / water / 2 h / 35 °C 3.2: 3 h / -3 °C 4.1: hydrogen; palladium on activated charcoal / methanol / 4 h / 30 °C / 3750.38 - 13501.4 Torr / Autoclave 5.1: sulfuric acid / 1 h / 83 °C 5.2: 1 h / -3 °C 5.3: 125 °C View Scheme

N-(2-nitro-4-(trifluoromethyl)phenyl)acetamide (396-12-3) → 3-Trifluoromethylphenol (98-17-9)

Conditions	Yield
Multi-step reaction with 4 steps 1.1: sulfuric acid / 5 h / 80 °C 2.1: sulfuric acid; acetic acid / water / 2 h / 35 °C 2.2: 3 h / -3 °C 3.1: hydrogen; palladium on activated charcoal / methanol / 4 h / 30 °C / 3750.38 - 13501.4 Torr / Autoclave 4.1: sulfuric acid / 1 h / 83 °C 4.2: 1 h / -3 °C 4.3: 125 °C View Scheme

4-trifluoromethyl-2-nitroaniline (400-98-6) → 3-Trifluoromethylphenol (98-17-9)

Conditions	Yield
Multi-step reaction with 3 steps 1.1: sulfuric acid; acetic acid / water / 2 h / 35 °C 1.2: 3 h / -3 °C 2.1: hydrogen; palladium on activated charcoal / methanol / 4 h / 30 °C / 3750.38 - 13501.4 Torr / Autoclave 3.1: sulfuric acid / 1 h / 83 °C 3.2: 1 h / -3 °C 3.3: 125 °C View Scheme

N-Trifluoromethyl-N-nitrosobenzenesulfonamide (80783-62-6) + phenol (108-95-2) → 4-hydroxybenzotrifluoride (402-45-9) + 2-(trifluoromethyl)phenol (444-30-4) + 3-Trifluoromethylphenol (98-17-9)

Conditions	Yield
With dimethylglyoxal In acetonitrile for 5h; Irradiation; Yield given. Yields of byproduct given. Title compound not separated from byproducts;

3-(trifluoromethyl)phenyl 4-methylbenzenesulfonate (131086-40-3) + acetone (67-64-1) → 3-Trifluoromethylphenol (98-17-9)

Conditions	Yield
With bis[chloro(1,2,3-trihapto-allylbenzene)palladium(II)]; N-[2-(di(1-adamantyl)phosphino)phenyl]morpholine; caesium carbonate at 90℃; for 16h; Inert atmosphere; sealed vial;

(4-Nitro-phenyl)-acetic acid 3-trifluoromethyl-phenyl ester (75993-61-2) → 4-nitrobenzeneacetic acid (104-03-0) + 3-Trifluoromethylphenol (98-17-9)

Conditions	Yield
With barium dihydroxide In water; dimethyl sulfoxide at 30℃; Rate constant; Mechanism;

diazotized 3-amino-trifluoromethyl-benzene → 3-Trifluoromethylphenol (98-17-9)

Conditions	Yield
With sulfuric acid

3-Trifluoromethylphenol (98-17-9) + methyl iodide (74-88-4) → 3-(trifluoromethyl)anisole (454-90-0)

Conditions	Yield
With potassium carbonate In acetone at 0 - 20℃; for 18h;	100%
With potassium carbonate In acetone at 0 - 20℃; for 18h; Inert atmosphere;	100%
With sodium hydride In tetrahydrofuran for 12h;	80%

3-Trifluoromethylphenol (98-17-9) + p-toluenesulfonyl chloride (98-59-9) → 3-(trifluoromethyl)phenyl 4-methylbenzenesulfonate (131086-40-3)

Conditions	Yield
With potassium carbonate In tetrahydrofuran; water at 0 - 20℃; for 2h; Green chemistry;	100%
Stage #1: 3-Trifluoromethylphenol With potassium hydroxide In tetrahydrofuran at 20℃; for 0.0833333h; Inert atmosphere; Stage #2: p-toluenesulfonyl chloride In tetrahydrofuran at 60℃; Inert atmosphere;	96%
Stage #1: 3-Trifluoromethylphenol With potassium hydroxide In tetrahydrofuran at 20℃; for 0.0833333h; Inert atmosphere; Stage #2: p-toluenesulfonyl chloride In tetrahydrofuran at 20 - 60℃; Inert atmosphere;	96%

3-Trifluoromethylphenol (98-17-9) → potassium 3-(trifluoromethyl)phenolate (56705-78-3)

Conditions	Yield
With potassium tert-butylate for 0.5h; Inert atmosphere;	100%
With potassium tert-butylate for 0.5h;
With potassium tert-butylate for 0.00833333h; Schlenk technique; Inert atmosphere;

+ 3-Trifluoromethylphenol (98-17-9) → 1-(5-chlorobenzoxazol-2-yl)-1-(3-(trifluoromethyl)phenoxy)butane

Conditions	Yield
With potassium carbonate In acetonitrile for 1h; Heating / reflux;	100%

3-Trifluoromethylphenol (98-17-9) + propargyl bromide (106-96-7) → 1-(prop-2-yn-1-yloxy)-3-(trifluoromethyl)benzene (17061-88-0)

Conditions	Yield
With potassium carbonate In acetone; toluene for 24h; Williamson Ether Synthesis; Reflux;	100%
With potassium carbonate In acetone for 24h; Inert atmosphere; Reflux;	96.4%
With caesium carbonate In acetonitrile	85%

3-Trifluoromethylphenol + N,N-Dimethylcarbamoyl chloride (79-44-7) → 3-(trifluoromethyl)phenyl dimethylcarbamate (722-08-7)

Conditions	Yield
Stage #1: 3-Trifluoromethylphenol With sodium hydride In N,N-dimethyl-formamide; mineral oil at 0℃; Inert atmosphere; Stage #2: N,N-Dimethylcarbamoyl chloride In N,N-dimethyl-formamide; mineral oil at 0 - 20℃; for 3h; Inert atmosphere;	98%
With triethylamine
With triethylamine

3-Trifluoromethylphenol (98-17-9) + (R)-2,2-dimethyl-1,3-dioxolane-4-ylmethyl p-toluenesulfonate (23788-74-1) → (S)-(+)-2,2-dimethyl-4-(3-trifluoromethylphenoxy)methyl-1,3-dioxolane

Conditions	Yield
Stage #1: 3-Trifluoromethylphenol With sodium hydroxide In ethanol; water for 0.166667h; Stage #2: (R)-2,2-dimethyl-1,3-dioxolane-4-ylmethyl p-toluenesulfonate In ethanol; water for 20h; Solvent; Reagent/catalyst; Temperature; Reflux;	98%
Stage #1: 3-Trifluoromethylphenol With sodium hydroxide In ethanol; water for 0.166667h; Stage #2: (R)-2,2-dimethyl-1,3-dioxolane-4-ylmethyl p-toluenesulfonate In ethanol; water for 20h; Reflux;	89%
Stage #1: 3-Trifluoromethylphenol With sodium hydroxide In ethanol; water for 0.166667h; Stage #2: (R)-2,2-dimethyl-1,3-dioxolane-4-ylmethyl p-toluenesulfonate In ethanol; water for 20h; Reflux;	88.7%

3-Trifluoromethylphenol (98-17-9) + sodium 2-bromo-2,2-difluoro-acetate → α,α-difluoro(3-trifluoromethylphenoxy)acetic acid

Conditions	Yield
Stage #1: 3-Trifluoromethylphenol With sodium hydride In 1,4-dioxane at 20℃; for 0.5h; Inert atmosphere; Schlenk technique; Stage #2: sodium 2-bromo-2,2-difluoro-acetate In 1,4-dioxane at 80℃; for 20h; Inert atmosphere;	98%

3-Trifluoromethylphenol (98-17-9) + methanesulfonyl chloride (124-63-0) → 3-(trifluoromethyl)phenyl methanesulfonate (52904-17-3)

Conditions	Yield
With triethylamine In ethyl acetate at 0 - 20℃; for 0.166667h; Green chemistry;	97%
With triethylamine In dichloromethane at 0℃; for 0.5h;	92%
With pyridine

3-Trifluoromethylphenol (98-17-9) + chloroacetonitrile (107-14-2) → (3-trifluoromethylphenoxy)acetonitrile (2145-31-5)

Conditions	Yield
With potassium carbonate In acetone Heating;	97%

4-[(4-fluorophenyl)sulfonyl]tetrahydro-N-[(tetrahydro-2H-pyran-2-yl)oxy]-2H-pyran-4-carboxamide (226389-21-5) + 3-Trifluoromethylphenol (98-17-9) → C24H26F3NO7S (226399-23-1)

Conditions	Yield
With caesium carbonate In N,N-dimethyl acetamide at 95℃; for 21h;	97%

vinyl acetate (108-05-4) + 3-Trifluoromethylphenol (98-17-9) → 3-(trifluoromethyl)phenyl acetate (78950-34-2)

Conditions	Yield
With 1,4-diaza-bicyclo[2.2.2]octane In neat (no solvent) at 70 - 140℃; for 0.183333h; Microwave irradiation;	97%

3-Trifluoromethylphenol (98-17-9) + t-butyldimethylsilyl amine (41879-37-2) → tert-butyl-di-methyl(3-(trifluoromethyl)phenoxy)silane

Conditions	Yield
In neat (no solvent) at 20℃; for 0.5h; Green chemistry;	97%

C13H13F3N4O5S + 3-Trifluoromethylphenol (98-17-9) → C19H14F6N4O4

Conditions	Yield
With sodium hydride In tetrahydrofuran at 20℃;	96.8%

3-Trifluoromethylphenol (98-17-9) + (S)-(+)-(2,2-dimethyl-[1,3]dioxolan-4-yl)methanol (22323-82-6) → (S)-(+)-2,2-dimethyl-4-(3-trifluoromethylphenoxy)methyl-1,3-dioxolane

Conditions	Yield
With di-isopropyl azodicarboxylate; triphenylphosphine In toluene at 90 - 100℃; for 1.5h; Mitsunobu Displacement;	96.46%

3-Trifluoromethylphenol (98-17-9) + 1-Bromo-2-bromomethyl-benzene (3433-80-5) → 1-bromo-2-[3-(trifluoromethyl)phenoxymethyl]benzene (248582-57-2)

Conditions	Yield
With potassium carbonate In acetone for 7h; Substitution; Heating;	96%

3-Trifluoromethylphenol (98-17-9) + ethyl 2-bromomethyl-2-propenoate (17435-72-2) → 2-(3-trifluoromethyl-phenoxymethyl)-acrylic acid ethyl ester (1004992-01-1)

Conditions	Yield
Stage #1: 3-Trifluoromethylphenol; ethyl 2-bromomethyl-2-propenoate With potassium carbonate In acetone for 1.5h; Heating / reflux; Stage #2: With triethylamine for 0.166667h;	96%

Upstream product

• 693-03-8 n-butyl magnesium bromide 
• 75-44-5 phosgene 
• 60-29-7 diethyl ether 
• 733-22-2 1-methoxy-4-(3-trifluoromethyl-phenoxy)-benzene 
• 80783-62-6 N-Trifluoromethyl-N-nitrosobenzenesulfonamide 
• 108-95-2 phenol 
• 585-49-9 1-(prop-2-en-1-yloxy)-3-(trifluoromethyl)benzene 
• 1423-26-3 (meta-(trifluoromethyl)phenyl)boronic acid 
• 587-50-8 bis-(3-trifluoromethyl-phenyl)-ether 
• 401-78-5 3-bromo-1-trifluoromethylbenzene 
• 98-08-8 α,α,α-trifluorotoluene 
• 2249-29-8 m-trifluoromethylphenyl-N-butylcarbamate 
• 70097-64-2 1-(benzyloxy)-3-(trifluoromethyl)benzene 
• 1245824-29-6 meta-trifluoromethylphenyl N,N-diethylcarbamate 

Downstream Products

• 401-75-2 trifluoromethylcyclohexane 
• 454-63-7 3-(trifluoromethyl)cyclohexan-1-ol 
• 384-87-2 2,4,6-tribromo-3-trifluoromethyl-phenol 
• 384-77-0 2,4,6-trinitro-3-trifluoromethyl-phenol 
• 402-05-1 2-bromo-5-(trifluoromethyl)phenol 
• 393-00-0 2,6-dichloro-3-trifluoromethyl-phenol 
• 320-52-5 2,4-dibromo-5-trifluoromethyl-phenol 
• 381-26-0 phosphoric acid tris-(3-trifluoromethyl-phenyl ester) 
• 585-49-9 1-(prop-2-en-1-yloxy)-3-(trifluoromethyl)benzene 
• 585-45-5 2-((3-(trifluoromethyl)phenoxy)methyl)oxirane 
• 16221-35-5 1-Propargyloxy-3-<3-trifluormethyl-phenoxy>-propanol-(2) 
• 17336-26-4 -triphenyl-silan 
• 130715-90-1 8-chloro-2,4-dimethyl-6-nitro-5-(3-trifluoromethylphenoxy)quinoline 
• 75993-61-2 (4-Nitro-phenyl)-acetic acid 3-trifluoromethyl-phenyl ester 

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A general method for the demethylation, debenzylation, and deallylation of aryl ethers using HPPh2andtBuOK is reported. The reaction features mild and metal-free reaction conditions, broad substrate scope, good functional group compatibility, and high chemical selectivity towards aryl ethers over aliphatic structures. Notably, this approach is competent to selectively deprotect the allyl or benzyl group, making it a general and practical method in organic synthesis.

Synthetic method of m-trifluoromethylphenol

The invention belongs to the field of organic synthesis, and particularly relates to a synthetic method of m-trifluoromethylphenol. The method comprises the following steps: (1) in a solvent, carrying out Williamson reaction on m-chlorobenzotrifluoride and tert-butyl alcohol under the catalysis of sodium hydride and metal acetate to prepare an intermediate m-trifluoromethylbenzene tert-butyl ether; (2) in a solvent, carrying out tertiary butyl removal on the m-trifluoromethyl benzene tert-butyl ether prepared in the step (1) under the action of a ZSM-5 molecular sieve to prepare the trifluoromethylphenol. The synthesis steps are simple, the cost is low, and the process is more environment-friendly.