Benzenesulfonamide, N-[2,3-dihydro-7-(hydroxyphenylmethyl)-1,4-benzodioxin-6-yl]-4-methyl-

Base Information

Chemical Name:Benzenesulfonamide, N-[2,3-dihydro-7-(hydroxyphenylmethyl)-1,4-benzodioxin-6-yl]-4-methyl-
CAS No.:886493-41-0
Molecular Formula:C22H21NO5S
Molecular Weight:411.478
Hs Code.:

Synonyms:N-[7-(Hydroxy-phenyl-methyl)-2,3-dihydro-benzo[1,4]dioxin-6-yl]-4-methyl-benzenesulfonamide;

Suppliers and Price of Benzenesulfonamide, N-[2,3-dihydro-7-(hydroxyphenylmethyl)-1,4-benzodioxin-6-yl]-4-methyl-

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Crysdot
N-(7-(Hydroxy(phenyl)methyl)-2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-4-methylbenzenesulfonamide 97%
1g
$ 643.00

Total 1 raw suppliers

Chemical Property of Benzenesulfonamide, N-[2,3-dihydro-7-(hydroxyphenylmethyl)-1,4-benzodioxin-6-yl]-4-methyl-

Chemical Property:

Melting Point:90 - 91 °C (acetone)
PSA：93.24000
LogP:4.80250

Purity/Quality:

97% ^*data from raw suppliers

N-(7-(Hydroxy(phenyl)methyl)-2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-4-methylbenzenesulfonamide 97% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of Benzenesulfonamide, N-[2,3-dihydro-7-(hydroxyphenylmethyl)-1,4-benzodioxin-6-yl]-4-methyl-

There total 6 articles about Benzenesulfonamide, N-[2,3-dihydro-7-(hydroxyphenylmethyl)-1,4-benzodioxin-6-yl]-4-methyl- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

: 886493-75-0
7-benzoyl-6-(4-methylphenylsulfonamido)-2,3-dihydro-1,4-benzodioxine

: 886493-41-0
7-[hydroxy(phenyl)methyl]-6-(4-methylphenylsulfonamido)-2,3-dihydro-1,4-benzodioxine

Guidance literature:: With sodium tetrahydroborate; In ethanol; Heating;
DOI:10.1016/j.tet.2006.10.056

Reference yield:

: 493-09-4
benzo-1,4-dioxane

: 886493-41-0
7-[hydroxy(phenyl)methyl]-6-(4-methylphenylsulfonamido)-2,3-dihydro-1,4-benzodioxine

Guidance literature:: Multi-step reaction with 5 steps

1: AlCl₃ / benzene / 2.5 h / 55 - 60 °C

2: 78 percent / HNO₃; AcOH / 0.5 h / 0 - 20 °C

3: 74 percent / Fe; AcOH / H₂O; ethyl acetate / 6 h / Heating

4: 79 percent / pyridine / 1 h / 20 °C

5: 83 percent / NaBH₄ / ethanol / Heating

With pyridine; sodium tetrahydroborate; aluminium trichloride; nitric acid; iron; acetic acid; In ethanol; water; ethyl acetate; benzene; 1: Friedel-Crafts reaction;
DOI:10.1016/j.tet.2006.10.056

Reference yield:

: 98-88-4
benzoyl chloride

: 886493-41-0
7-[hydroxy(phenyl)methyl]-6-(4-methylphenylsulfonamido)-2,3-dihydro-1,4-benzodioxine

Guidance literature:: Multi-step reaction with 5 steps

1: AlCl₃ / benzene / 2.5 h / 55 - 60 °C

2: 78 percent / HNO₃; AcOH / 0.5 h / 0 - 20 °C

3: 74 percent / Fe; AcOH / H₂O; ethyl acetate / 6 h / Heating

4: 79 percent / pyridine / 1 h / 20 °C

5: 83 percent / NaBH₄ / ethanol / Heating

With pyridine; sodium tetrahydroborate; aluminium trichloride; nitric acid; iron; acetic acid; In ethanol; water; ethyl acetate; benzene; 1: Friedel-Crafts reaction;
DOI:10.1016/j.tet.2006.10.056