1H-Indole-6-carboxylic acid, 3-formyl-

Base Information

• Chemical Name: 1H-Indole-6-carboxylic acid, 3-formyl-
• CAS No.: 887576-06-9
• Molecular Formula: C10H7NO3
• Molecular Weight: 189.17
• Hs Code.: 2933998090
• Mol file: 887576-06-9.mol

Synonyms:methyl 3-formyl-1H-indazole-4-carboxylate;3-Formyl-4-indazolecarboxylic acid methyl ester;3-formyl-indole-6-carboxylic acid;4-METHOXYCARBONYL-INDAZOLE-3-ALDEHYDE;Methyl-3-al-4-indazole carboxylate;Methyl 3-formyl-4-indazolecarboxylate;3-Formyl-1H-indazole-4-carboxylic acid methyl ester;

Chemical Property of 1H-Indole-6-carboxylic acid, 3-formyl-

Chemical Property:

• PSA: 70.16000
• LogP: 1.67860

Purity/Quality:

97% ^*data from raw suppliers

3-formyl-1H-indole-6-carboxylicacid ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1H-Indole-6-carboxylic acid, 3-formyl-

There total 1 articles about 1H-Indole-6-carboxylic acid, 3-formyl- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

methyl 3-formyl-6-indolecarboxylate (133831-28-4) → 3-formyl-indole-6-carboxylic acid (887576-06-9)

Guidance literature:

With water; lithium hydroxide; In tetrahydrofuran;

DOI:10.1016/j.bmcl.2010.08.103

Reference yield: 46.0%

4-phenylpiperidine (771-99-3) + 3-formyl-indole-6-carboxylic acid (887576-06-9) → 6-(4-phenyl-piperidine-1-carbonyl)-1H-indole-3-carbaldehyde (1056002-08-4)

Guidance literature:

With 1-hydroxy-7-aza-benzotriazole; triethylamine; bromo-tris(1-pyrrolidinyl)phosphonium hexafluorophosphate; In N,N-dimethyl-formamide; for 24h;

Reference yield:

3-formyl-indole-6-carboxylic acid (887576-06-9) → [3-(4-cyclobutyl-piperazine-1-ylmethyl)-1H-indol-6-yl]-(4-phenyl-piperidin-1-yl)-methanone (1056000-53-3)

Guidance literature:

Multi-step reaction with 2 steps

1: 1-hydroxy-7-aza-benzotriazole; triethylamine; bromo-tris(1-pyrrolidinyl)phosphonium hexafluorophosphate / N,N-dimethyl-formamide / 24 h

2: macroporous reticular thacetoxy borohydride resin / N,N-dimethyl-formamide / 24 h

With 1-hydroxy-7-aza-benzotriazole; triethylamine; bromo-tris(1-pyrrolidinyl)phosphonium hexafluorophosphate; In N,N-dimethyl-formamide;

upstream raw materials:

methyl 3-formyl-6-indolecarboxylate

Downstream raw materials:

6-(4-phenyl-piperidine-1-carbonyl)-1H-indole-3-carbaldehyde

[3-(4-cyclobutyl-piperazine-1-ylmethyl)-1H-indol-6-yl]-(4-phenyl-piperidin-1-yl)-methanone