9-(4-hydroxy-2-(hydroxymethyl)butyl)guanine

Base Information

• Chemical Name: 9-(4-hydroxy-2-(hydroxymethyl)butyl)guanine
• CAS No.: 105868-85-7
• Molecular Formula: C₁₀H₁₅N₅O₃
• Molecular Weight: 253.261
• Mol file: 105868-85-7.mol

Synonyms:6H-Purin-6-one,2-amino-1,9-dihydro-9-[4-hydroxy-2-(hydroxymethyl)butyl]-, (?à)-

Chemical Property of 9-(4-hydroxy-2-(hydroxymethyl)butyl)guanine

Chemical Property:

• Vapor Pressure: 3.85E-17mmHg at 25°C
• Boiling Point: 637.8°C at 760 mmHg
• Flash Point: 339.5°C
• PSA: 131.04000
• Density: 1.68g/cm³
• LogP: -0.96490

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 9-(4-hydroxy-2-(hydroxymethyl)butyl)guanine

There total 6 articles about 9-(4-hydroxy-2-(hydroxymethyl)butyl)guanine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 52.0%

ethyl 3-(2-N-acetyl-6-O-(diphenylcarbamoyl)guanin-9-ylmethyl)-2-(hydroxymethyl)propanoate (553646-42-7) → 2-(guanin-9-ylmethyl)butane-1,4-diol (174289-69-1,105868-85-7,126922-86-9)

Guidance literature:

ethyl 3-(2-N-acetyl-6-O-(diphenylcarbamoyl)guanin-9-ylmethyl)-2-(hydroxymethyl)propanoate; With lithium borohydride; In ethanol; at 20 ℃; for 7h;

With ammonia; In methanol; at 20 ℃; for 12h;

DOI:10.1016/S0040-4020(03)00190-X

Reference yield:

dimethyl 2-(2-amino-6-chloropurin-9-ylmethyl)-succinate (126617-59-2,99776-31-5) → 2-(guanin-9-ylmethyl)butane-1,4-diol (174289-69-1,105868-85-7,126922-86-9)

Guidance literature:

With lithium borohydride; In water; butan-1-ol;

Reference yield:

dimethyl 2-(2-amino-6-chloropurin-9-ylmethyl)-succinate (126617-59-2,99776-31-5) + Trimethyl borate (121-43-7,63156-11-6) → 2-(guanin-9-ylmethyl)butane-1,4-diol (174289-69-1,105868-85-7,126922-86-9)

Guidance literature:

With lithium bromide; sodium borohydrid; In formic acid; diethylene glycol dimethyl ether; water;

upstream raw materials:

ethyl 3-(2-N-acetyl-6-O-(diphenylcarbamoyl)guanin-9-ylmethyl)-2-(hydroxymethyl)propanoate

N₂-acetyl-O₆-(diphenylcarbamoyl)guanine

methanol

dimethyl 2-(2-amino-6-chloropurin-9-ylmethyl)-succinate