4-Piperidinone, 3-bromo-1-methyl-, hydrobromide

Base Information

• Chemical Name: 4-Piperidinone, 3-bromo-1-methyl-, hydrobromide
• CAS No.: 89580-42-7
• Molecular Formula: C6H10BrNO.BrH
• Molecular Weight: 272.967
• Mol file: 89580-42-7.mol

Synonyms:4-Piperidinone,3-bromo-1-methyl-,hydrobromide;

Chemical Property of 4-Piperidinone, 3-bromo-1-methyl-, hydrobromide

Chemical Property:

• Melting Point: 120-122℃
• PSA: 20.31000
• LogP: 1.55050

Purity/Quality:

98%,99%, ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-Piperidinone, 3-bromo-1-methyl-, hydrobromide

There total 1 articles about 4-Piperidinone, 3-bromo-1-methyl-, hydrobromide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.3%

1-Methyl-4-piperidone (1445-73-4) → 3-bromo-1-methylpiperidin-4-one hydrobromide (89580-42-7)

Guidance literature:

With hydrogen bromide; bromine; acetic acid; In water; at 20 - 25 ℃; Large scale;

Reference yield: 9.3%

3-bromo-1-methylpiperidin-4-one hydrobromide (89580-42-7) + (2E)-but-2-enedioic acid (110-17-8,26099-09-2) + 2-phenylthioacetamide (645-54-5) → 2-benzyl-5-methyl-4,5,6,7-tetrahydrothiazole[5,4-c]pyridine fumarate

Guidance literature:

3-bromo-1-methylpiperidin-4-one hydrobromide; 2-phenylthioacetamide; With calcium carbonate; In isopropyl alcohol; for 10h; Heating;

(2E)-but-2-enedioic acid; In methanol;

DOI:10.1016/S0968-0896(02)00557-6

Reference yield:

3-bromo-1-methylpiperidin-4-one hydrobromide (89580-42-7) → 2-Bromo-5-methyl-4,5,6,7-tetrahydrothiazolo[5,4-c]-pyridine (143150-92-9)

Guidance literature:

Multi-step reaction with 2 steps

1: ethanol / 75 - 80 °C

2: hydrogen bromide; sodium nitrite / water / 3 h / 10 - 25 °C

With hydrogen bromide; sodium nitrite; In ethanol; water;

upstream raw materials:

1-Methyl-4-piperidone

Downstream raw materials:

2-Bromo-5-methyl-4,5,6,7-tetrahydrothiazolo[5,4-c]-pyridine

5-methyl-4,5,6,7-tetrahydro[1,3]thiazolo[5,4-c]pyridine-2-carboxylic acid hydrochloric acid salt

edoxaban

[14C]-Edoxaban tosylate

Refernces

• 1、 -. "Preparation method of edoxaban". Paragraph 0175-0180. . Retrieved 2019/07/08.