POLY-L-METHIONINE

Base Information

• Chemical Name: POLY-L-METHIONINE
• CAS No.: 26062-47-5
• Molecular Formula: C5H11NO2S
• Molecular Weight: 149.21
• Mol file: 26062-47-5.mol

Synonyms:Poly-L-methionine;L-Methionine, homopolymer;

Chemical Property of POLY-L-METHIONINE

Chemical Property:

• Melting Point: 280-282oC
• Boiling Point: 306.9°Cat760mmHg
• Flash Point: 139.4°C
• PSA: 88.62000
• Density: 1.206g/cm³
• LogP: 0.85170
• Storage Temp.: -20°C

Purity/Quality:

98%min ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of POLY-L-METHIONINE

There total 272 articles about POLY-L-METHIONINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

N-tert-butoxycarbonyl-L-methionine (2488-15-5) → L-methionine (63-68-3,26062-47-5,58576-49-1)

Guidance literature:

With water; at 170 ℃; for 0.05h; Microwave irradiation;

DOI:10.1016/j.tetlet.2008.09.027

Reference yield: 96.0%

(S)-4'-(2-(methylthio)ethyl)-9λ4-boraspiro[bicyclo[3.3.1]nonane-9,2'-[1,3,2]oxazaborolidin]-5'-one → L-methionine (63-68-3,26062-47-5,58576-49-1)

Guidance literature:

With tetrabutyl ammonium fluoride; In tetrahydrofuran; water; at 20 ℃; for 1h;

DOI:10.1002/ejoc.201700063

Reference yield: 95.0%

DL-methionine (59-51-8,26062-47-5,58576-49-1) → L-methionine (63-68-3,26062-47-5,58576-49-1)

Guidance literature:

In water; at 37 ℃; for 10h; NADH, ammonium chloride, sodium formate, D-amino acid oxidase, catalase, leucine dehydrogenase, formate dehydrogenase, Tris-HCl buffer, pH 8.5;

DOI:10.1039/c39900000947

upstream raw materials:

(E)-4-methylsulfanylbut-2-enoic acid

α-amino-γ-methylmercapto-butyronitrile

2-amino-4-mercaptobutyric acid

dimethylsulfonioacetate

Downstream raw materials:

D-methionine methyl ester

methyl D-methioninate hydrochloride

N-[(2,4,5-trichloro-phenoxy)-acetyl]-D-methionine

N-[(2,4-dichloro-phenoxy)-acetyl]-D-methionine

Refernces

• 1、 Landgraf, Bradley J.,Booker, Squire J.. "Stereochemical Course of the Reaction Catalyzed by RimO, a Radical SAM Methylthiotransferase". . p. 2889 - 2892. Retrieved 2016.
• 2、 Ishikawa, Takahiro,Watabe, Ken,Mukohara, Yukuo,Nakamura, Hiroaki. "Mechanism of stereospecific conversion of DL-5-substituted hydantoins to the corresponding L-amino acids by Pseudomonas sp. strain NS671". . p. 185 - 187. Retrieved 1997.
• 3、 Wardenga, Rainer,Lindner, Holger A.,Hollmann, Frank,Thum, Oliver,Bornscheuer, Uwe. "Increasing the synthesis/hydrolysis ratio of aminoacylase 1 by site-directed mutagenesis". . p. 102 - 109. Retrieved 2010.
• 4、 Lawson,Schramm. "-". . p. 2017. Retrieved 1962.
• 5、 Ubhi, Devinder,Kavanagh, Kathryn L.,Monzingo, Arthur F.,Robertus, Jon D.. "Structure of Candida albicans methionine synthase determined by employing surface residue mutagenesis". . p. 19 - 26. Retrieved 2011.
• 6、 Jeanjean, Fabien,Perol, Nathalie,Gore, Jacques,Fournet, Guy. "Asymmetric carboxylation in the synthesis of L-methionine: A new tool for 11C chemistry". . p. 7547 - 7550. Retrieved 1997.
• 7、 Hands,Millidge,Walker. "-". . p. 365,371. Retrieved 1947.
• 8、 Tarrago, Lionel,Kaya, Alaattin,Weerapana, Eranthie,Marino, Stefano M.,Gladyshev, Vadim N.. "Methionine sulfoxide reductases preferentially reduce unfolded oxidized proteins and protect cells from oxidative protein unfolding". . p. 24448 - 24459. Retrieved 2012.
• 9、 Wei, Haiying,Liu, Qin,Lin, Jun,Jiang, Pengju,Guo, Zijian. "Fast displacement of S,N-chelated L-methionine in platinum(II) complexes by biological thiols". . p. 792 - 794. Retrieved 2004.
• 10、 Helgren, Travis R.,Seven, Elif S.,Chen, Congling,Edwards, Thomas E.,Staker, Bart L.,Abendroth, Jan,Myler, Peter J.,Horn, James R.,Hagen, Timothy J.. "The identification of inhibitory compounds of Rickettsia prowazekii methionine aminopeptidase for antibacterial applications". . p. 1376 - 1380. Retrieved 2018.