Boc-L-methionine

Base Information

• Chemical Name: Boc-L-methionine
• CAS No.: 2488-15-5
• Molecular Formula: C10H19NO4S
• Molecular Weight: 249.331
• Hs Code.: 2930 90 98
• European Community (EC) Number: 219-639-3
• Nikkaji Number: J191.976H
• Wikidata: Q76006123
• ChEMBL ID: CHEMBL117467
• Mol file: 2488-15-5.mol

Synonyms:Boc-L-methionine;2488-15-5;Boc-Met-OH;N-Boc-L-methionine;Boc-L-Met-OH;(TERT-BUTOXYCARBONYL)-L-METHIONINE;N-(tert-Butoxycarbonyl)-L-methionine;tert-Butoxycarbonyl-L-methionine;Methionine, N-[(1,1-dimethylethoxy)carbonyl]-;L-Methionine, N-[(1,1-dimethylethoxy)carbonyl]-;(2S)-2-[(2-methylpropan-2-yl)oxycarbonylamino]-4-methylsulfanylbutanoic acid;(2S)-2-{[(tert-butoxy)carbonyl]amino}-4-(methylsulfanyl)butanoic acid;EINECS 219-639-3;(S)-2-(TERT-BUTOXYCARBONYLAMINO)-4-(METHYLTHIO)BUTANOIC ACID;MFCD00065586;L-Methionine, N-((1,1-dimethylethoxy)carbonyl)-;Boc-methionine;C10-H19-N-O4-S;boc-l-met;N-Boc methionine;N-tert-butoxycarbonyl-L-methionine;(S)-Boc-methionine;N-Boc-L-Met-OH;Boc-Met-OH, 99%;SCHEMBL352156;N-tert-butoxycarbonylmethionine;CHEMBL117467;teri-butoxycarbonyl-L-methionine;n-(t-butoxycarbonyl)-l-methionine;N-tert-butoxycarbonyl L-methionine;BCP08139;Boc-L-Methionine (Boc-L-Met-OH);STR07511;(S)-N-(tert-butoxycarbonyl)methionine;AKOS010397674;nalpha-tert-butoxycarbonyl-l-methionine;CS-W010218;HY-W009502;N-(tert-Butyloxycarbonyl)-L-methionine;(s)-n-(tert-butoxycarbonyl) methionine;B1636;EN300-52851;N-(tert-Butoxycarbonyl)(methyl)homocysteine #;D70229;A817531;J-300196;(S)-2-tert-Butoxycarbonylamino-4-methylsulfanyl-butyric acid;(2S)-2-(tert-butoxycarbonylamino)-4-methylsulfanyl-butanoate;Boc-L-Methionine

Chemical Property of Boc-L-methionine

Chemical Property:

• Appearance/Colour: white to off-white microcrystalline powder
• Vapor Pressure: 4.56E-08mmHg at 25°C
• Melting Point: 47-53 °C
• Refractive Index: -22 ° (C=1.3, AcOH)
• Boiling Point: 415.5 °C at 760 mmHg
• PKA: 3.83±0.10(Predicted)
• Flash Point: 205.1 °C
• PSA: 100.93000
• Density: 1.16 g/cm³
• LogP: 2.10830
• Storage Temp.: 2-8°C
• Solubility.: almost transparency in Methanol
• XLogP3: 1.6
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 5
• Rotatable Bond Count: 7
• Exact Mass: 249.10347926
• Heavy Atom Count: 16
• Complexity: 250

Purity/Quality:

99% ^*data from raw suppliers

Boc-L-methionine ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xn
• Hazard Codes: Xn
• Statements: 20/21/22-36/37/38
• Safety Statements: 24/25-36-26

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC(C)(C)OC(=O)NC(CCSC)C(=O)O
• Isomeric SMILES: CC(C)(C)OC(=O)N[C@@H](CCSC)C(=O)O
• Uses: N-Boc-L-methionine is an N-Boc-protected form of L-Methionine (M260440). L-Methionine is an essential amino acid that is obtained from our diet. L-Methionine can be found in grain legumes (such as lentils), and poultry. L-Methionine’s main function is to act as the primary “Start” sequence on mRNA so that the ribosomes can start translating the mRNA into proteins.

Technology Process of Boc-L-methionine

There total 23 articles about Boc-L-methionine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

L-methionine (63-68-3,26062-47-5,58576-49-1) + di-tert-butyl dicarbonate (24424-99-5) → N-tert-butoxycarbonyl-L-methionine (2488-15-5)

Guidance literature:

L-methionine; With sodium hydroxide; In 1,4-dioxane; water; at 0 ℃; for 0.25h;

di-tert-butyl dicarbonate; In 1,4-dioxane; water; at 0 - 20 ℃;

DOI:10.1128/AAC.01152-16

Reference yield: 96.0%

L-methionine (63-68-3,26062-47-5,58576-49-1) → N-tert-butoxycarbonyl-L-methionine (2488-15-5)

Guidance literature:

With triethylamine; In water; N,N-dimethyl-formamide; for 7h; Ambient temperature;

DOI:10.1246/cl.1984.237

Reference yield: 96.0%

tert-butyl pyridin-2-yl carbonate (89985-91-1) + L-methionine, dicyclohexylammonium salt → 2-hydroxypyridin (142-08-5) + N-tert-butoxycarbonyl-L-methionine (2488-15-5)

Guidance literature:

With triethylamine; In water; N,N-dimethyl-formamide; for 7h; Ambient temperature;

DOI:10.1246/bcsj.58.3570

upstream raw materials:

N-(tert-butyloxycarbonyl) azide

L-methionine

trimethylacetyl azide

tert-butyl fluoroformate

Downstream raw materials:

tertbutoxycarbonyl-L-methionine N-hydroxysuccinimide ester

N-tert-butyloxycarbonyl-L-methionine pentachlorophenyl ester

[(S)-3-Methylsulfanyl-1-(N'-phenyl-hydrazinocarbonyl)-propyl]-carbamic acid tert-butyl ester

C₆₂H₈₃N₁₃O₁₂S

Refernces

• 1、 Almeida, B. G.,Amaral, V. S.,Castanheira, Elisabete M. S.,Coutinho, Paulo J. G.,Ferreira, Paula M. T.,Hilliou, Loic,Jervis, Peter J.,Martins, J. A.,Moreira, Rute,O. Amorim, C.,Pereira, David M.,Veloso, Sérgio R. S.. "Dehydropeptide-based plasmonic magnetogels: A supramolecular composite nanosystem for multimodal cancer therapy". . p. 45 - 64. Retrieved 2019.
• 2、 Astley, Demet,Isik, Erkut,Yasa, Ihsan,Yuksekdanaci, Seda. "Synthesis, characterization and antimicrobial activity of some novel 1-substituted benzimidazole derivatives". . p. 1372 - 1379. Retrieved 2020/10/06.
• 3、 -. "DIPEPTIDE MIMETICS OF NGF AND BDNF NEUROTROPHINS". Paragraph 0187. . Retrieved 2019/04/16.