Methylphenylsilanediol

Base Information

• Chemical Name: Methylphenylsilanediol
• CAS No.: 3959-13-5
• Molecular Formula: C7H10O2Si
• Molecular Weight: 154.241
• Hs Code.: 2931900090
• European Community (EC) Number: 223-562-0
• UNII: 4K77J04LV5
• DSSTox Substance ID: DTXSID8073972
• Nikkaji Number: J217.792G
• Wikidata: Q27259827
• Mol file: 3959-13-5.mol

Synonyms:Methylphenylsilanediol;3959-13-5;dihydroxy-methyl-phenylsilane;Silanediol, methylphenyl-;methyl(phenyl)silanediol;phenylmethylsilanediol;UNII-4K77J04LV5;4K77J04LV5;dihydroxymethylphenylsilane;EINECS 223-562-0;SILANEDIOL, 1-METHYL-1-PHENYL-;C7H10O2Si;SCHEMBL271787;C7-H10-O2-Si;DTXSID8073972;methyl-bis(oxidanyl)-phenyl-silane;AKOS030255148;A824637;Q27259827

Chemical Property of Methylphenylsilanediol

Chemical Property:

• Vapor Pressure: 0.0112mmHg at 25°C
• Refractive Index: 1.542
• Boiling Point: 250.6 °C at 760 mmHg
• Flash Point: 105.4 °C
• PSA: 40.46000
• Density: 1.12 g/cm³
• LogP: -0.04980
• Storage Temp.: Hygroscopic, Refrigerator, under inert atmosphere
• Solubility.: Chloroform (Slightly), Methanol (Slightly)
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 1
• Exact Mass: 154.045006092
• Heavy Atom Count: 10
• Complexity: 108

Purity/Quality:

98%Min ^*data from raw suppliers

Methylphenylsilanediol ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C[Si](C1=CC=CC=C1)(O)O
• Uses: Methylphenylsilanediol acts as a reagent used in the synthetic preparation of (tetramethylnapthalenyl)silanol derivative and in the determination of their activity as selective inhibitors of adult T-cell leukemia (ATL)

Technology Process of Methylphenylsilanediol

There total 9 articles about Methylphenylsilanediol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

dimethoxy(methyl)phenylsilane (3027-21-2) → methyl(phenyl)silanediol (3959-13-5,31230-04-3)

Guidance literature:

With water; In acetonitrile; at 25 ℃; for 0.0833333h;

Reference yield: 99.0%

methylphenylsilane (766-08-5,146088-00-8) → methyl(phenyl)silanediol (3959-13-5,31230-04-3)

Guidance literature:

With oxygen; In water; acetone; at 30 ℃; for 0.333333h; under 760.051 Torr;

DOI:10.1246/cl.150379

Reference yield: 81.0%

bis(2-thienyl)methylphenylsilane (31650-28-9) → methyl(phenyl)silanediol (3959-13-5,31230-04-3)

Guidance literature:

With trifluoroacetic acid; In dichloromethane; at 0 ℃; for 2h;

DOI:10.1016/j.tetlet.2006.03.095

upstream raw materials:

Dichloromethylsilane

diethoxy-methyl-phenyl-silane

dichloromethylphenylsilane

dimethoxy(methyl)phenylsilane

Downstream raw materials:

1,5-dichloro-1,1,3,5,5-pentamethyl-3-phenyltrisiloxane

1,5-divinyl-1,1,5,5-tetramethoxy-3-phenyl-3-methyltrisiloxane

C₂₉H₃₆Cl₆O₆Si₇

2,2,6,6-Tetraethoxy-4,8-dimethyl-4,8-diphenyl-[1,3,5,7,2,4,6,8]tetroxatetrasilocane

Refernces

• 1、 Kannengie?er, Jan-Falk,Briesenick, Max,Meier, Dennis,Huch, Volker,Morgenstern, Bernd,Kickelbick, Guido. "Synthesis and Hydrogen-Bond Patterns of Aryl-Group Substituted Silanediols and -triols from Alkoxy- and Chlorosilanes". . p. 16461 - 16476. Retrieved 2021/10/25.
• 2、 Nakamura, Masaharu,Matsumoto, Yotaro,Toyama, Masaaki,Baba, Masanori,Hashimoto, Yuichi. "Organosilicon compounds as adult T-cell leukemia cell proliferation inhibitors". . p. 237 - 241. Retrieved 2013/03/14.