2-Methyoxy-3-methyl-2-phenyl-4H-benzo-g-pyranone

Base Information

• Chemical Name: 2-Methyoxy-3-methyl-2-phenyl-4H-benzo-g-pyranone
• CAS No.: 18651-16-6
• Molecular Formula: C17H14 O3
• Molecular Weight: 266.296
• Hs Code.: 2914509090
• Mol file: 18651-16-6.mol

Synonyms:Flavone,7-methoxy-3-methyl- (6CI,8CI); NSC 80479

Chemical Property of 2-Methyoxy-3-methyl-2-phenyl-4H-benzo-g-pyranone

Chemical Property:

• Vapor Pressure: 1.68E-07mmHg at 25°C
• Boiling Point: 427.1°Cat760mmHg
• Flash Point: 203.9°C
• PSA: 39.44000
• Density: 1.203g/cm³
• LogP: 3.77700
• Solubility.: Acetic Acid; Dichloromethane; Ethyl Acetate; Methanol

Purity/Quality:

98%min ^*data from raw suppliers

7-Methoxy-3-methyl-flavone ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 7-Methoxy-3-methyl-flavone is an intermediate in synthesizing Dimefline Hydrochloride (D448250). Dimefline is a new respiratory stimulant drug.

Technology Process of 2-Methyoxy-3-methyl-2-phenyl-4H-benzo-g-pyranone

There total 7 articles about 2-Methyoxy-3-methyl-2-phenyl-4H-benzo-g-pyranone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.4%

2-hydroxy-4-methoxypropiophenone (6270-44-6) + benzoyl chloride (98-88-4) → 3-methyl-7-methoxy-2-phenyl-4H-benzopyran-4-one (18651-16-6)

Guidance literature:

With sodium benzoate; at 160 - 170 ℃;

Reference yield: 72.0%

α-Methyl-2'-hydroxy-4'-methoxychalcon (69792-77-4) → 3-methyl-7-methoxy-2-phenyl-4H-benzopyran-4-one (18651-16-6)

Guidance literature:

With iodine; In dimethyl sulfoxide; Reflux;

Reference yield:

1-(2-hydroxy-4-methoxy-phenyl)-2-methyl-3-phenyl-propane-1,3-dione (412017-82-4) → 3-methyl-7-methoxy-2-phenyl-4H-benzopyran-4-one (18651-16-6)

Guidance literature:

With hydrogenchloride; acetic acid;

DOI:10.1039/jr9520003826

upstream raw materials:

1-(2-hydroxy-4-methoxy-phenyl)-2-methyl-3-phenyl-propane-1,3-dione

2-hydroxy-4-methoxypropiophenone

benzoyl chloride

2',4'-dihydroxypropiophenone

Downstream raw materials:

7-Acetyloxy-3-methylflavone

Dimefline

8-acetoxymethyl-7-methoxy-3-methyl-2-phenyl-chromen-4-one

8-hydroxymethyl-7-methoxy-3-methyl-2-phenyl-chromen-4-one

Refernces

• 1、 Jayashree, B. S.,Alam, Afroze,Vijay Kumar, D.,Nayak, Yogendra. "Synthesis of 3-methylflavones and their antioxidant and antibacterial activities". . p. 1991 - 1996,6. Retrieved 2020/07/30.