Technology Process of 1,3-Cyclohexadiene-1-carboxylic acid,
5-[[(1,1-dimethylethoxy)carbonyl]amino]-, (S)-
There total 21 articles about 1,3-Cyclohexadiene-1-carboxylic acid,
5-[[(1,1-dimethylethoxy)carbonyl]amino]-, (S)- which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
water; lithium hydroxide;
In
tetrahydrofuran;
at 20 ℃;
for 8h;
DOI:10.1002/ejoc.201300977
- Guidance literature:
-
Multi-step reaction with 2 steps
1: 1,8-diazabicyclo[5.4.0]undec-7-ene / dichloromethane / 0.17 h / 20 °C
2: lithium hydroxide; water / tetrahydrofuran / 8 h / 20 °C
With
water; 1,8-diazabicyclo[5.4.0]undec-7-ene; lithium hydroxide;
In
tetrahydrofuran; dichloromethane;
DOI:10.1002/ejoc.201300977
- Guidance literature:
-
Multi-step reaction with 12 steps
1: lithium aluminium tetrahydride / tetrahydrofuran / 1 h / 0 °C
2: oxalyl dichloride; dimethyl sulfoxide; triethylamine / dichloromethane / 3 h / -78 °C
3: tetrahydrofuran / 1 h / -15 - 20 °C
4: camphor-10-sulfonic acid / 2.5 h / 0 - 20 °C
5: tetrabutyl ammonium fluoride / tetrahydrofuran / 1.5 h / 0 - 20 °C
6: oxalyl dichloride; dimethyl sulfoxide; triethylamine / dichloromethane / 3 h / -78 °C
7: 1,4-diaza-bicyclo[2.2.2]octane / 48 h / 20 °C
8: Hoveyda-Grubbs catalyst second generation / toluene / 6 h / 80 °C
9: pyridinium p-toluenesulfonate / methanol / 24 h / 20 °C
10: pyridine / dichloromethane / 1 h / -78 °C
11: 1,8-diazabicyclo[5.4.0]undec-7-ene / dichloromethane / 0.17 h / 20 °C
12: lithium hydroxide; water / tetrahydrofuran / 8 h / 20 °C
With
pyridine; 1,4-diaza-bicyclo[2.2.2]octane; lithium aluminium tetrahydride; Hoveyda-Grubbs catalyst second generation; oxalyl dichloride; camphor-10-sulfonic acid; tetrabutyl ammonium fluoride; water; pyridinium p-toluenesulfonate; dimethyl sulfoxide; 1,8-diazabicyclo[5.4.0]undec-7-ene; triethylamine; lithium hydroxide;
In
tetrahydrofuran; methanol; dichloromethane; toluene;
2: |Swern Oxidation / 3: |Grignard Reaction / 6: |Swern Oxidation / 7: |Morita-Baylis-Hillman Alkylation;
DOI:10.1002/ejoc.201300977
