2-Benzofurancarboxylic acid, 7-chloro-5-[(2-fluorophenyl)(hydroxyimino)methyl]-2,3-dihydro-6-hydroxy -, ethyl ester, (E)-

Base Information

Chemical Name:2-Benzofurancarboxylic acid, 7-chloro-5-[(2-fluorophenyl)(hydroxyimino)methyl]-2,3-dihydro-6-hydroxy -, ethyl ester, (E)-
CAS No.:90246-88-1
Molecular Formula:C18H15ClFNO5
Molecular Weight:379.772
Hs Code.:

Synonyms:

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Chemical Property of 2-Benzofurancarboxylic acid, 7-chloro-5-[(2-fluorophenyl)(hydroxyimino)methyl]-2,3-dihydro-6-hydroxy -, ethyl ester, (E)-

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of 2-Benzofurancarboxylic acid, 7-chloro-5-[(2-fluorophenyl)(hydroxyimino)methyl]-2,3-dihydro-6-hydroxy -, ethyl ester, (E)-

There total 8 articles about 2-Benzofurancarboxylic acid, 7-chloro-5-[(2-fluorophenyl)(hydroxyimino)methyl]-2,3-dihydro-6-hydroxy -, ethyl ester, (E)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 20.0%

: 90246-78-9
ethyl 7-chloro-2,3-dihydro-5-(o-fluorobenzoyl)-6-hydroxybenzofuran-2-carboxylate

: 90246-88-1
ethyl (E)-7-chloro-2,3-dihydro-5-(o-fluorobenzoyl)-6-hydroxybenzofuran-2-carboxylate oxime

Guidance literature:: With pyridine; hydroxylamine hydrochloride; for 4h; Heating;
DOI:10.1021/jm00374a014

Reference yield:

: 7051-15-2
2-chlororesorcinol dimethyl ether

: 90246-88-1
ethyl (E)-7-chloro-2,3-dihydro-5-(o-fluorobenzoyl)-6-hydroxybenzofuran-2-carboxylate oxime

Guidance literature:: Multi-step reaction with 8 steps

1: 79 percent / TiCl₄ / CH₂Cl₂ / 1 h / 0 °C

2: 74 percent / BBr₃ / CH₂Cl₂ / 1 h / 0 °C

3: 79.6 percent / K₂CO₃ / butan-2-one / 4.5 h / Heating

4: 82.9 percent / H₂, conc.H₂SO₄ / 20percent Pd/C / acetic acid / 2 h / 2280 Torr

5: LiCl, Me₂SO, H₂O / 2 h / Heating

6: H₂SO₄ / Ambient temperature

7: 69.2 percent / AlCl₃ / 1,2-dichloro-ethane / 3.75 h / 5 - 20 °C

8: 20 percent / NH₂OH*HCl, pyridine / 4 h / Heating

With pyridine; aluminium trichloride; sulfuric acid; hydroxylamine hydrochloride; water; hydrogen; boron tribromide; titanium tetrachloride; potassium carbonate; dimethyl sulfoxide; lithium chloride; palladium on activated charcoal; In dichloromethane; acetic acid; 1,2-dichloro-ethane; butanone;
DOI:10.1021/jm00374a014

Reference yield:

: 72482-15-6
3-chloro-2-hydroxy-4-methoxybenzaldehyde

: 90246-88-1
ethyl (E)-7-chloro-2,3-dihydro-5-(o-fluorobenzoyl)-6-hydroxybenzofuran-2-carboxylate oxime

Guidance literature:: Multi-step reaction with 6 steps

1: 79.6 percent / K₂CO₃ / butan-2-one / 4.5 h / Heating

2: 82.9 percent / H₂, conc.H₂SO₄ / 20percent Pd/C / acetic acid / 2 h / 2280 Torr

3: LiCl, Me₂SO, H₂O / 2 h / Heating

4: H₂SO₄ / Ambient temperature

5: 69.2 percent / AlCl₃ / 1,2-dichloro-ethane / 3.75 h / 5 - 20 °C

6: 20 percent / NH₂OH*HCl, pyridine / 4 h / Heating

With pyridine; aluminium trichloride; sulfuric acid; hydroxylamine hydrochloride; water; hydrogen; potassium carbonate; dimethyl sulfoxide; lithium chloride; palladium on activated charcoal; In acetic acid; 1,2-dichloro-ethane; butanone;
DOI:10.1021/jm00374a014