3-Chloro-4-Methoxysalicylaldehyde

Base Information

• Chemical Name: 3-Chloro-4-Methoxysalicylaldehyde
• CAS No.: 72482-15-6
• Molecular Formula: C8H7ClO3
• Molecular Weight: 186.595
• Mol file: 72482-15-6.mol

Synonyms:3-Chloro-4-methoxysalicylaldehyde;

Chemical Property of 3-Chloro-4-Methoxysalicylaldehyde

Chemical Property:

• Boiling Point: 275.1±35.0 °C(Predicted)
• PKA: 6.32±0.15(Predicted)
• PSA: 46.53000
• Density: 1.377±0.06 g/cm3(Predicted)
• LogP: 1.86670

Purity/Quality:

99% ^*data from raw suppliers

3-Chloro-4-methoxysalicylaldehyde ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3-Chloro-4-Methoxysalicylaldehyde

There total 5 articles about 3-Chloro-4-Methoxysalicylaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.6%

formaldehyd (50-00-0,30525-89-4,61233-19-0) + 2-chloro-3-methoxyphenol (72232-49-6) → 3-chloro-2-hydroxy-4-methoxybenzaldehyde (72482-15-6)

Guidance literature:

2-chloro-3-methoxyphenol; With triethylamine; magnesium chloride; In acetonitrile; at 0 ℃; for 0.166667h;

formaldehyd; In acetonitrile; at 0 - 75 ℃; for 4h;

Reference yield: 74.0%

3-chloro-2,4-dimethoxybenzaldehyde (72482-14-5) → 3-chloro-2-hydroxy-4-methoxybenzaldehyde (72482-15-6)

Guidance literature:

With boron tribromide; In dichloromethane; at 0 ℃; for 1h;

DOI:10.1021/jm00374a014

Reference yield: 65.0%

2-Hydroxy-4-methoxybenzaldehyde (673-22-3) → 5-chloro-2-hydroxy-4-methoxy-benzaldehyde (89938-56-7) + 3-chloro-2-hydroxy-4-methoxybenzaldehyde (72482-15-6)

Guidance literature:

With 2,2,6,6-tetramethyl-piperidine; sulfuryl dichloride; In toluene; at 70 ℃; Inert atmosphere;

DOI:10.1021/ol201561w

upstream raw materials:

3-chloro-2,4-dimethoxybenzaldehyde

2-chlororesorcinol dimethyl ether

2-Hydroxy-4-methoxybenzaldehyde

formaldehyd

Downstream raw materials:

(R)-3-[(S)-8-Chloro-3-(2-fluoro-phenyl)-5,6-dihydro-furo[2',3':4,5]benzo[1,2-d]isoxazole-6-carbonyl]-4-phenyl-oxazolidin-2-one

(R)-3-[(R)-8-Chloro-3-(2-fluoro-phenyl)-5,6-dihydro-furo[2',3':4,5]benzo[1,2-d]isoxazole-6-carbonyl]-4-phenyl-oxazolidin-2-one

(S)-8-Chloro-3-(2-fluoro-phenyl)-5,6-dihydro-furo[2',3':4,5]benzo[1,2-d]isoxazole-6-carboxylic acid

(R)-8-Chloro-3-(2-fluoro-phenyl)-5,6-dihydro-furo[2',3':4,5]benzo[1,2-d]isoxazole-6-carboxylic acid

Refernces

• 1、 -. "ISOINDOLINE-1-ONE DERIVATIVES AS CHOLINERGIC MUSCARINIC M1 RECEPTOR POSITIVE ALLOESTERIC MODULATOR ACTIVITY FOR THE TREATMENT OF ALZHEIMERS DISEASE". Paragraph 0412. . Retrieved 2015/11/10.
• 2、 Yu, Min,Snider, Barry B.. "Syntheses of chloroisosulochrin and isosulochrin and biomimetic elaboration to maldoxin, maldoxone, dihydromaldoxin, and dechlorodihydromaldoxin". scheme or table. p. 4224 - 4227. Retrieved 2011/10/18.