1-Methyl-2-nitro-6-phenylimidazo[4,5-b]pyridine

Base Information

• Chemical Name: 1-Methyl-2-nitro-6-phenylimidazo[4,5-b]pyridine
• CAS No.: 129018-59-3
• Molecular Formula: C13H10 N4 O2
• Molecular Weight: 254.248
• DSSTox Substance ID: DTXSID40156035
• Nikkaji Number: J389.986A
• Wikidata: Q83024028
• Mol file: 129018-59-3.mol

Synonyms:2-nitro-1-methyl-6-phenylimidazo(4,5-b)pyridine;NO2-PhIP

Chemical Property of 1-Methyl-2-nitro-6-phenylimidazo[4,5-b]pyridine

Chemical Property:

• Vapor Pressure: 2.61E-10mmHg at 25°C
• Melting Point: 171-174°C
• Boiling Point: 504.6°Cat760mmHg
• Flash Point: 259°C
• PSA: 76.53000
• Density: 1.4g/cm³
• LogP: 3.06670
• Storage Temp.: Amber Vial, -20°C Freezer
• Solubility.: DMSO, Methanol
• XLogP3: 2.7
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 1
• Exact Mass: 254.08037557
• Heavy Atom Count: 19
• Complexity: 340

Purity/Quality:

97% ^*data from raw suppliers

1-Methyl-2-nitro-6-phenylimidazo[4,5-B]pyridine(90%) ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CN1C2=C(N=CC(=C2)C3=CC=CC=C3)N=C1[N+](=O)[O-]
• Uses: Shows potent mutagenic activity in the reversion assay of Salmonella typhimurium 1-Methyl-2-nitro-6-phenylimidazo[4,5-B]pyridine is a chemical used in mutagenesis research.

Technology Process of 1-Methyl-2-nitro-6-phenylimidazo[4,5-b]pyridine

There total 2 articles about 1-Methyl-2-nitro-6-phenylimidazo[4,5-b]pyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-amino-1-methyl-6-phenyl-1H-imidazo[4,5-b]pyridine (105650-23-5) → 2-nitro-1-methyl-6-phenyl-1H-imidazo[4,5-b]pyridine (129018-59-3)

Guidance literature:

With acetic acid; sodium nitrite; In water; at 0 - 20 ℃; for 3.5h;

DOI:10.1021/jo070306p

Reference yield:

1-methyl-6-phenyl-1H-imidazo[4,5-b]pyridine (125572-33-0) → 2-nitro-1-methyl-6-phenyl-1H-imidazo[4,5-b]pyridine (129018-59-3)

Guidance literature:

Multi-step reaction with 2 steps

1: 20 percent Turnov_. / 15-crown-5; NaNH₂ / xylene / 1.5 h / 130 °C

2: 52 percent Turnov_. / NaNO₂; acetic acid / H₂O / 3.5 h / 0 - 20 °C

With 15-crown-5; sodium amide; acetic acid; sodium nitrite; In water; xylene; 1: Chichibabin reaction;

DOI:10.1021/jo070306p

Reference yield: 95.0%

2-nitro-1-methyl-6-phenyl-1H-imidazo[4,5-b]pyridine (129018-59-3) → 2-hydroxy-1-methyl-6-phenyl-1H-imidazo[4,5-b]pyridine

Guidance literature:

With water; In N,N-dimethyl-formamide; at 100 ℃; for 0.166667h;

DOI:10.1021/jo070306p

upstream raw materials:

2-amino-1-methyl-6-phenyl-1H-imidazo[4,5-b]pyridine

1-methyl-6-phenyl-1H-imidazo[4,5-b]pyridine

Downstream raw materials:

N-Hydroxy-PhIP

C₁₈H₂₀N₄O₂

C₁₉H₂₃N₅O₂

tyrosine

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 129018-59-3 1-Methyl-2-nitro-6-phenylimidazo[4,5-B]pyridine

Send

Send

Metric Ton KG G Pound L ML

Send

Send