L-Gamma-Glutamyl-S-Benzyl-N-[(S)-Carboxy(Phenyl)methyl]-L-Cysteinamide

Base Information

Chemical Name:L-Gamma-Glutamyl-S-Benzyl-N-[(S)-Carboxy(Phenyl)methyl]-L-Cysteinamide
CAS No.:152684-53-2
Molecular Formula:C₂₃H₂₇N₃O₆S
Molecular Weight:473.55
Hs Code.:
UNII:LJ5T8BSZ4G
Nikkaji Number:J577.196J
Mol file:152684-53-2.mol

Synonyms:ezatiotsat;gamma-Glu-S-BzCys-PhGly diethyl ester;gamma-glutamyl-S-(benzyl)cysteinyl-phenylglycine diethyl ester;T.199;Telintra;TER 199;TER-199;TLK 117;TLK 199;TLK-117;TLK-199;TLK117;TLK199

Suppliers and Price of L-Gamma-Glutamyl-S-Benzyl-N-[(S)-Carboxy(Phenyl)methyl]-L-Cysteinamide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

ChemScene
TLK117 98.32%
10mg
$ 280.00

ChemScene
TLK117 98.32%
5mg
$ 180.00

Total 1 raw suppliers

Chemical Property of L-Gamma-Glutamyl-S-Benzyl-N-[(S)-Carboxy(Phenyl)methyl]-L-Cysteinamide

Chemical Property:

Boiling Point:832.7±65.0 °C(Predicted)
PKA:2.21±0.10(Predicted)
Density:1.346±0.06 g/cm3(Predicted)
XLogP3:-0.9
Hydrogen Bond Donor Count:5
Hydrogen Bond Acceptor Count:8
Rotatable Bond Count:13
Exact Mass:473.16205676
Heavy Atom Count:33
Complexity:665

Purity/Quality:

99% ^*data from raw suppliers

TLK117 98.32% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:C1=CC=C(C=C1)CSCC(C(=O)NC(C2=CC=CC=C2)C(=O)O)NC(=O)CCC(C(=O)O)N
Isomeric SMILES:C1=CC=C(C=C1)CSC[C@@H](C(=O)N[C@H](C2=CC=CC=C2)C(=O)O)NC(=O)CC[C@@H](C(=O)O)N

Technology Process of L-Gamma-Glutamyl-S-Benzyl-N-[(S)-Carboxy(Phenyl)methyl]-L-Cysteinamide

There total 6 articles about L-Gamma-Glutamyl-S-Benzyl-N-[(S)-Carboxy(Phenyl)methyl]-L-Cysteinamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: (S)-4-{(R)-2-Benzylsulfanyl-1-[((S)-ethoxycarbonyl-phenyl-methyl)-carbamoyl]-ethylcarbamoyl}-2-(9H-fluoren-9-ylmethoxycarbonylamino)-butyric acid benzyl ester

: 152684-53-2
(S)-γ-glutamyl-(R)-S-(benzyl)cysteinyl-(R)-phenylglycine

Guidance literature:: With sodium hydroxide; In tetrahydrofuran; for 1h;

Reference yield:

: 2935-35-5
(S)-2-phenylglycine

: 152684-53-2
(S)-γ-glutamyl-(R)-S-(benzyl)cysteinyl-(R)-phenylglycine

Guidance literature:: Multi-step reaction with 5 steps

1: 93 percent / SOCl₂ / 40 °C

2: diisopropylethylamine, DCC / CH₂Cl₂ / 5 h

3: piperidine / dimethylformamide / 1 h

4: DCC / CH₂Cl₂; dimethylformamide / 3 h

5: aq. NaOH / tetrahydrofuran / 1 h

With piperidine; sodium hydroxide; thionyl chloride; N-ethyl-N,N-diisopropylamine; dicyclohexyl-carbodiimide; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide;

Reference yield:

: 59410-82-1
(S)-α-phenylglycine ethyl ester hydrochloride

: 152684-53-2
(S)-γ-glutamyl-(R)-S-(benzyl)cysteinyl-(R)-phenylglycine

Guidance literature:: Multi-step reaction with 4 steps

1: diisopropylethylamine, DCC / CH₂Cl₂ / 5 h

2: piperidine / dimethylformamide / 1 h

3: DCC / CH₂Cl₂; dimethylformamide / 3 h

4: aq. NaOH / tetrahydrofuran / 1 h

With piperidine; sodium hydroxide; N-ethyl-N,N-diisopropylamine; dicyclohexyl-carbodiimide; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide;