Cyclohexanebutanoic acid, 1,3-dimethyl-2-methylene-b-oxo-, methyl ester, cis-

Base Information

Chemical Name:Cyclohexanebutanoic acid, 1,3-dimethyl-2-methylene-b-oxo-, methyl ester, cis-
CAS No.:90461-18-0
Molecular Formula:C₁₄H₂₂O₃
Molecular Weight:238.327
Hs Code.:

Synonyms:

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Chemical Property of Cyclohexanebutanoic acid, 1,3-dimethyl-2-methylene-b-oxo-, methyl ester, cis-

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Technology Process of Cyclohexanebutanoic acid, 1,3-dimethyl-2-methylene-b-oxo-, methyl ester, cis-

There total 5 articles about Cyclohexanebutanoic acid, 1,3-dimethyl-2-methylene-b-oxo-, methyl ester, cis- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 64287-34-9
2,6-Dimethylcyclohexanone tosylhydrazone

: 90461-18-0
4-((1R,3R)-1,3-Dimethyl-2-methylene-cyclohexyl)-3-oxo-butyric acid methyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: 1) n-BuLi, TMEDA / 1) THF, a) -35 deg C, 3h b) -10 to 0 deg C, 2-3h 2) -> room temperature

2: 90.5 percent / NaBH₄ / methanol / 1) ice bath 2) room temperature, 2h

3: 1) propionic acid 2) 2N aqueous NaOH / 1) a) 3h, 110-120 deg C b) 140-150 deg C 2) MeOH, 4h, 50 deg C

4: 43.4 percent / diethyl ether / 1) ice bath 2) 3h, room temperature

5: 1) NaH / 1) diglyme, 30 min 2) 8h, 60 deg C

With sodium hydroxide; sodium tetrahydroborate; n-butyllithium; N,N,N,N,-tetramethylethylenediamine; sodium hydride; propionic acid; In methanol; diethyl ether;
DOI:10.1021/jo00192a001

Reference yield:

: 102877-95-2
2,6-dimethyl-1-cyclohexenecarboxaldehyde

: 90461-18-0
4-((1R,3R)-1,3-Dimethyl-2-methylene-cyclohexyl)-3-oxo-butyric acid methyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: 90.5 percent / NaBH₄ / methanol / 1) ice bath 2) room temperature, 2h

2: 1) propionic acid 2) 2N aqueous NaOH / 1) a) 3h, 110-120 deg C b) 140-150 deg C 2) MeOH, 4h, 50 deg C

3: 43.4 percent / diethyl ether / 1) ice bath 2) 3h, room temperature

4: 1) NaH / 1) diglyme, 30 min 2) 8h, 60 deg C

With sodium hydroxide; sodium tetrahydroborate; sodium hydride; propionic acid; In methanol; diethyl ether;
DOI:10.1021/jo00192a001

Reference yield:

: 85428-12-2
(2,6-dimethylcyclohex-1-enyl)methanol

: 90461-18-0
4-((1R,3R)-1,3-Dimethyl-2-methylene-cyclohexyl)-3-oxo-butyric acid methyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 1) propionic acid 2) 2N aqueous NaOH / 1) a) 3h, 110-120 deg C b) 140-150 deg C 2) MeOH, 4h, 50 deg C

2: 43.4 percent / diethyl ether / 1) ice bath 2) 3h, room temperature

3: 1) NaH / 1) diglyme, 30 min 2) 8h, 60 deg C

With sodium hydroxide; sodium hydride; propionic acid; In diethyl ether;
DOI:10.1021/jo00192a001