102877-95-2

Upstream product

• 2816-57-1 2,6-dimethylcyclohexanone 
• 935-34-2 1-hydroxy-2,6-dimethylcyclohexanecarbonitrile 
• 113767-71-8 2,6-Dimethyl-1-trimethylsilanyloxy-cyclohexanecarbonitrile 
• 113767-72-9 2,6-dimethyl-1-cyclohexenecarbonitrile 
• 64287-34-9 2,6-Dimethylcyclohexanone tosylhydrazone 
• 68-12-2 N,N-dimethyl-formamide 

Downstream Products

• 113767-73-0 (2E,4E)-5-(2,6-dimethyl-1-cyclohexenyl)-3-methyl-2,4-pentadienal 
• 52152-27-9 1-demethylretinal 
• 85428-12-2 (2,6-dimethylcyclohex-1-enyl)methanol 
• 1261072-64-3 1-(2,6-dimethylcyclohex-1-enyl)-3-phenylprop-2-yn-1-ol 
• 1261072-65-4 (3-(2,6-dimethylcyclohex-1-enyl)-3-methoxyprop-1-ynyl)benzene 
• 85428-21-3 C₂₁H₂₈N₂O₄S 
• 85428-15-5 2-Diazo-4-((1R,3S)-1,3-dimethyl-2-methylene-cyclohexyl)-3-oxo-butyric acid methyl ester 
• 90461-14-6 2-Diazo-4-((1R,3R)-1,3-dimethyl-2-methylene-cyclohexyl)-3-oxo-butyric acid methyl ester 
• 85428-14-4 4-((1R,3S)-1,3-Dimethyl-2-methylene-cyclohexyl)-3-oxo-butyric acid methyl ester 
• 90461-18-0 4-((1R,3R)-1,3-Dimethyl-2-methylene-cyclohexyl)-3-oxo-butyric acid methyl ester 
• 85428-13-3 ((1R,3S)-1,3-Dimethyl-2-methylene-cyclohexyl)-acetic acid 
• 90461-15-7 ((1R,3R)-1,3-Dimethyl-2-methylene-cyclohexyl)-acetic acid 
• 85428-20-2 1-((1R,3S)-1,3-Dimethyl-2-methylene-cyclohexyl)-propan-2-one 
• 90461-17-9 1-((1R,3R)-1,3-Dimethyl-2-methylene-cyclohexyl)-propan-2-one 

Relevant academic research and scientific papers

Oxidation-initiated nazarov cyclization of vinyl alkoxyallenes

A mild method for the diastereoselective formation of C4, C 5-disubstituted cyclopentenones has been developed, involving formation of a pentadienyl cation via diastereoselective oxidation of a vinyl alkoxyallene. Conrotatory electrocyclization provides the cyclopentenone product. The broad scope, mild conditions, and uncommon substitution pattern accessible through this transformation make it a useful addition to the existing repertoire of cyclopentenone synthetic methods.

Bacteriorhodopsin. The influence of the cyclohexene-ring methyls

Four ring-demethylated retinals, viz. 1,1',5-tridemethylretinal, 1,1'-didemethylretinal, 1,5-didemethylretinal and 1-demethylretinal, have been synthesized via new and simple schemes.The properties of these modified retinals, their protonated Schiff bases and the corresponding bacteriorhodopsins have been studied and compared with the native system.These bacteriorhodopsin analogues have also been tested for their proton-pump efficiencies.A large decrease in proton-pump activity was found for the analogues lacking the 5-methyl group.On the whole, the opsin shifts of the modified bacteriorhodopsins were much lower than those of the native system.UV-Vis and 1H NMR data support a planar 6-s-trans conformation for the demethylated retinals in solution rather than a twisted 6-s-cis conformation (torsion angle 40-60 deg) as found in retinal.This explains the lower opsin shift and the better fit of these demethylated retinals in bacteriorhodopsin's binding site, which, in its native form, contains a 6-s-trans chromophore.

Total Synthesis of (+/-)-Cycloeudesmol and (+/-)- Epicycloeudesmol

The first total synthesis of both (+/-)-cycloeudesmol (3) and (+/-)-epicycloeudesmol (4) is described.The key stereospecific construction of the bicyclohexane system was conveniently achieved by an olefin-ketocarbene cyclization reaction.