ETHYL 7-METHYL-[1,2,4]TRIAZOLO[1,5-A]PYRIMIDINE-6-CARBOXYLATE

Base Information

• Chemical Name: ETHYL 7-METHYL-[1,2,4]TRIAZOLO[1,5-A]PYRIMIDINE-6-CARBOXYLATE
• CAS No.: 90558-96-6
• Molecular Formula: C9H10N4O2
• Molecular Weight: 206.20100
• Mol file: 90558-96-6.mol

Synonyms:7-Methyl-[1,2,4]triazolo[1,5-a]pyrimidin-6-carbonsaeure-aethylester;6-carbethoxy-7-methyl-1,2,4-triazolo[1,5-a]pyrimidine;7-Methyl-6-aethoxycarboxyl-s-triazolo[2,3-a]pyrimidin;7-methyl-[1,2,4]triazolo[1,5-a]pyrimidine-6-carboxylic acid ethyl ester;

Chemical Property of ETHYL 7-METHYL-[1,2,4]TRIAZOLO[1,5-A]PYRIMIDINE-6-CARBOXYLATE

Chemical Property:

• Melting Point: 102-104 °C(Solv: ethanol (64-17-5); water (7732-18-5))
• PKA: -0.04±0.30(Predicted)
• PSA: 69.38000
• Density: 1.39±0.1 g/cm3(Predicted)
• LogP: 0.60940

Purity/Quality:

99% ^*data from raw suppliers

ethyl7-methyl[1,2,4]triazolo[1,5-a]pyrimidine-6-carboxylate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of ETHYL 7-METHYL-[1,2,4]TRIAZOLO[1,5-A]PYRIMIDINE-6-CARBOXYLATE

There total 5 articles about ETHYL 7-METHYL-[1,2,4]TRIAZOLO[1,5-A]PYRIMIDINE-6-CARBOXYLATE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

3-amino-1,2,4-triazole (61-82-5) + 2-ethoxymethylene-3-oxobutanoic acid ethyl ester (3788-94-1) → ethyl 7-methyl[1,2,4]triazolo[2,3-a]pyrimidine-6-carboxylate (90558-96-6)

Guidance literature:

In ethanol; for 1h; Heating;

DOI:10.1007/s10593-005-0176-6

Reference yield: 57.0%

3(5)-amino-1,2,4-triazole (61-82-5) + 2-ethoxymethylene-3-oxobutanoic acid ethyl ester (3788-94-1) → ethyl 7-methyl[1,2,4]triazolo[2,3-a]pyrimidine-6-carboxylate (90558-96-6)

Guidance literature:

With acetic acid; regioselective reaction; Reflux;

DOI:10.1007/s11172-008-0163-z

Reference yield:

4-methyl-2-nitroamino-pyrimidine-5-carboxylic acid ethyl ester (100378-15-2) → ethyl 7-methyl[1,2,4]triazolo[2,3-a]pyrimidine-6-carboxylate (90558-96-6)

Guidance literature:

Multi-step reaction with 2 steps

1: N₂H₄+H₂O

With hydrazine hydrate;

upstream raw materials:

3⁽⁵⁾-amino-1,2,4-triazole

2-ethoxymethylene-3-oxobutanoic acid ethyl ester

2-hydrazino-4-methyl-pyrimidine-5-carboxylic acid ethyl ester

orthoformic acid triethyl ester

Downstream raw materials:

(E)-7-(2-dimethylaminovinyl)-6-ethoxycarbonyl[1,2,4]triazolo[1,5-a]pyrimidine

7-hydroxy-6,7-dihydropyrido[3,4-e][1,2,4]triazolo[1,5-a]pyrimidin-6-one

6-acetyl-7-hydroxy-1,2,4-triazolo[1,5-a]pyrimidine

7-methyl-[1,2,4]triazolo[1,5-a]pyrimidine-6-carboxylic acid

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