2,6,7-trideoxy-7-C-(2,4-dichlorophenyl)heptonic acid

Base Information

• Chemical Name: 2,6,7-trideoxy-7-C-(2,4-dichlorophenyl)heptonic acid
• CAS No.: 141267-47-2
• Molecular Formula: C13H16 Cl2 O5 . Na
• Molecular Weight: 345.15097
• Mol file: 141267-47-2.mol

Synonyms:2,6,7-trideoxy-7-C-(2,4-dichlorophenyl)heptonic acid

Chemical Property of 2,6,7-trideoxy-7-C-(2,4-dichlorophenyl)heptonic acid

Chemical Property:

• Vapor Pressure: 1.46E-14mmHg at 25°C
• Boiling Point: 585.7°Cat760mmHg
• Flash Point: 308°C
• PSA: 100.82000
• Density: g/cm³
• LogP: 0.14870

Purity/Quality:

99%min ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2,6,7-trideoxy-7-C-(2,4-dichlorophenyl)heptonic acid

There total 7 articles about 2,6,7-trideoxy-7-C-(2,4-dichlorophenyl)heptonic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

2,6,7-Trideoxy-7-C-(2,4-dichlorophenyl)-D-xylo-heptono-1,4-lactone (141240-37-1) → Sodium 2,6,7-trideoxy-7-C-(2,4-dichlorophenyl)-D-xylo-heptonate (141267-47-2)

Guidance literature:

With sodium hydroxide; In methanol; for 20h; Ambient temperature;

DOI:10.1016/S0008-6215(00)90499-3

Reference yield:

5,6-Dideoxy-6-C-(2,4-dichlorophenyl)-1-O-trityl-D-xylo-hexitol (141240-23-5) → Sodium 2,6,7-trideoxy-7-C-(2,4-dichlorophenyl)-D-xylo-heptonate (141267-47-2)

Guidance literature:

Multi-step reaction with 6 steps

1: 1) NaH, Me₂SO / 1) DMSO, 30 min., r.t, 2) DMSO, 2 h, r.t.

2: 78 percent / 2M HCl / CHCl₃; methanol / 48 h / 4 °C

3: 37 percent / triphenylphosphine, diethyl azodicarboxylate / benzene / Ambient temperature

4: 68.8 percent / K₂CO₃, 30percent H₂O₂ / dimethylsulfoxide / Ambient temperature

5: 72 percent / 2M HCl, H₂ / 10percent Pd / C / ethyl acetate; methanol / 4 h / Ambient temperature

6: 97 percent / 0.1 M NaOH / methanol / 20 h / Ambient temperature

With hydrogenchloride; sodium hydroxide; hydrogen; dihydrogen peroxide; sodium hydride; potassium carbonate; dimethyl sulfoxide; triphenylphosphine; diethylazodicarboxylate; palladium on activated charcoal; In methanol; chloroform; dimethyl sulfoxide; ethyl acetate; benzene;

DOI:10.1016/S0008-6215(00)90499-3

Reference yield:

5,6-Dideoxy-6-C-(2,4-dichlorophenyl)-2,3,4-tri-O-(4-methoxybenzyl)-D-xylo-hexitol (141240-36-0) → Sodium 2,6,7-trideoxy-7-C-(2,4-dichlorophenyl)-D-xylo-heptonate (141267-47-2)

Guidance literature:

Multi-step reaction with 4 steps

1: 37 percent / triphenylphosphine, diethyl azodicarboxylate / benzene / Ambient temperature

2: 68.8 percent / K₂CO₃, 30percent H₂O₂ / dimethylsulfoxide / Ambient temperature

3: 72 percent / 2M HCl, H₂ / 10percent Pd / C / ethyl acetate; methanol / 4 h / Ambient temperature

4: 97 percent / 0.1 M NaOH / methanol / 20 h / Ambient temperature

With hydrogenchloride; sodium hydroxide; hydrogen; dihydrogen peroxide; potassium carbonate; triphenylphosphine; diethylazodicarboxylate; palladium on activated charcoal; In methanol; dimethyl sulfoxide; ethyl acetate; benzene;

DOI:10.1016/S0008-6215(00)90499-3

upstream raw materials:

2,6,7-Trideoxy-7-C-(2,4-dichlorophenyl)-D-xylo-heptono-1,4-lactone

5,6-Dideoxy-6-C-(2,4-dichlorophenyl)-1-O-trityl-D-xylo-hexitol

5,6-Dideoxy-6-C-(2,4-dichlorophenyl)-2,3,4-tri-O-(4-methoxybenzyl)-D-xylo-hexitol

2,6,7-Trideoxy-7-C-(2,4-dichlorophenyl)-3,4,5-tri-O-(4-methoxybenzyl)-D-xylo-heptonitrile

Refernces