1-(2,2,2-Trifluoroethyl)piperidin-4-ol

Base Information

• Chemical Name: 1-(2,2,2-Trifluoroethyl)piperidin-4-ol
• CAS No.: 90633-29-7
• Molecular Formula: C7H12F3NO
• Molecular Weight: 183.17100
• European Community (EC) Number: 830-701-4
• Mol file: 90633-29-7.mol

Synonyms:1-(2,2,2-trifluoroethyl)piperidin-4-ol;90633-29-7;MFCD12147930;SCHEMBL445604;MCNPVLCNYWXFQS-UHFFFAOYSA-N;AKOS009172177;SB16046;BS-13683;1-(2,2,2-trifluoro-ethyl)piperidin-4-ol;CS-0056718;EN300-97801;P11363;F8889-7346;Z324648396

Chemical Property of 1-(2,2,2-Trifluoroethyl)piperidin-4-ol

Chemical Property:

• PSA: 23.47000
• LogP: 0.94330
• XLogP3: 1.2
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 5
• Rotatable Bond Count: 1
• Exact Mass: 183.08709849
• Heavy Atom Count: 12
• Complexity: 140

Purity/Quality:

97% ^*data from raw suppliers

1-(2,2,2-Trifluoroethyl)piperidin-4-ol ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1CN(CCC1O)CC(F)(F)F

Technology Process of 1-(2,2,2-Trifluoroethyl)piperidin-4-ol

There total 3 articles about 1-(2,2,2-Trifluoroethyl)piperidin-4-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

1-(2,2,2-trifluoroethyl)piperidin-4-one oxime (81363-14-6) → 1-(2,2,2-trifluoroethyl)piperidin-4-ol (90633-29-7)

Guidance literature:

With sodium tetrahydroborate; In methanol; at 20 ℃; for 16h;

Reference yield: 33.0%

4-HYDROXYPIPERIDINE (5382-16-1) + 2,2,2-trifluoroethyl methanesulfonate (25236-64-0) → 1-(2,2,2-trifluoroethyl)piperidin-4-ol (90633-29-7)

Guidance literature:

With triethylamine; In benzene; for 24h; Heating;

Reference yield:

4-HYDROXYPIPERIDINE (5382-16-1) + 2,2,2-trifluoroethyl trifluoromethanesulphonate (6226-25-1) → 1-(2,2,2-trifluoroethyl)piperidin-4-ol (90633-29-7)

Guidance literature:

With caesium carbonate; In N,N-dimethyl-formamide; at 90 ℃; for 3h;

upstream raw materials:

4-HYDROXYPIPERIDINE

2,2,2-trifluoroethyl methanesulfonate

2,2,2-trifluoroethyl trifluoromethanesulphonate

1-(2,2,2-trifluoroethyl)piperidin-4-one oxime

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